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Protein

H-2 class II histocompatibility antigen, A-K beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-K beta chain
Gene namesi
Name:H2-Ab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 224197ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 26318CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • early endosome Source: MGI
  • external side of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • multivesicular body Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Add
BLAST
Chaini28 – 263236H-2 class II histocompatibility antigen, A-K beta chainPRO_0000018996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 104
Glycosylationi46 – 461N-linked (GlcNAc...)1 Publication
Disulfide bondi143 ↔ 199

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiP06343.

Expressioni

Gene expression databases

CleanExiMM_H2-AB1.

Interactioni

Protein-protein interaction databases

DIPiDIP-6134N.
IntActiP06343. 1 interaction.
MINTiMINT-1533566.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 4512Combined sources
Helixi47 – 493Combined sources
Beta strandi50 – 5910Combined sources
Beta strandi62 – 687Combined sources
Turni69 – 713Combined sources
Beta strandi73 – 786Combined sources
Helixi79 – 813Combined sources
Helixi82 – 9110Combined sources
Helixi93 – 975Combined sources
Helixi99 – 1024Combined sources
Helixi104 – 1107Combined sources
Turni111 – 1155Combined sources
Helixi116 – 1183Combined sources
Beta strandi124 – 1318Combined sources
Beta strandi135 – 1373Combined sources
Beta strandi139 – 15113Combined sources
Beta strandi154 – 1596Combined sources
Beta strandi162 – 1643Combined sources
Beta strandi168 – 1703Combined sources
Beta strandi177 – 1793Combined sources
Beta strandi181 – 1899Combined sources
Beta strandi196 – 2027Combined sources
Beta strandi210 – 2156Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9KX-ray3.20D/H30-216[»]
1IAKX-ray1.90B34-216[»]
1JL4X-ray4.30B34-216[»]
ProteinModelPortaliP06343.
SMRiP06343. Positions 30-216.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06343.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 21189Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 12093Beta-1Add
BLAST
Regioni121 – 21494Beta-2Add
BLAST
Regioni215 – 22410Connecting peptide

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPSLLL LAAVVVLTVL SSPGTEGGNS ERHFVHQFQP FCYFTNGTQR
60 70 80 90 100
IRLVIRYIYN REEYVRFDSD VGEYRAVTEL GRPDAEYWNK QYLERTRAEL
110 120 130 140 150
DTVCRHNYEK TETPTSLRRL EQPSVVISLS RTEALNHHNT LVCSVTDFYP
160 170 180 190 200
AKIKVRWFRN GQEETVGVSS TQLIRNGDWT FQVLVMLEMT PRRGEVYTCH
210 220 230 240 250
VEHPSLKSPI TVEWRAQSES ARSKMLSGIG GCVLGVIFLG LGLFIRHRSQ
260
KGPRGPPPAG LLQ
Length:263
Mass (Da):29,967
Last modified:January 1, 1988 - v1
Checksum:i48F8FB38370EADF8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361H → Y in AAA57291 (PubMed:3692165).Curated
Sequence conflicti55 – 551I → T in AAA57291 (PubMed:3692165).Curated
Sequence conflicti64 – 652YV → FM in AAA57291 (PubMed:3692165).Curated
Sequence conflicti85 – 851A → V in AAA57291 (PubMed:3692165).Curated
Sequence conflicti90 – 901K → S in AAA57291 (PubMed:3692165).Curated
Sequence conflicti114 – 1141P → H in AAA57291 (PubMed:3692165).Curated
Sequence conflicti120 – 1201L → F in AAA57291 (PubMed:3692165).Curated
Sequence conflicti124 – 1241S → N in AAA57291 (PubMed:3692165).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13538 mRNA. Translation: AAA39632.1.
M27456 Genomic DNA. Translation: AAA57291.1.
PIRiA02238. HLMSBK.
I68208.
PL0285.
PL0286.
UniGeneiMm.254067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13538 mRNA. Translation: AAA39632.1.
M27456 Genomic DNA. Translation: AAA57291.1.
PIRiA02238. HLMSBK.
I68208.
PL0285.
PL0286.
UniGeneiMm.254067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9KX-ray3.20D/H30-216[»]
1IAKX-ray1.90B34-216[»]
1JL4X-ray4.30B34-216[»]
ProteinModelPortaliP06343.
SMRiP06343. Positions 30-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6134N.
IntActiP06343. 1 interaction.
MINTiMINT-1533566.

Proteomic databases

PRIDEiP06343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Phylogenomic databases

HOVERGENiHBG012730.

Miscellaneous databases

EvolutionaryTraceiP06343.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AB1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHB2K_MOUSE
AccessioniPrimary (citable) accession number: P06343
Secondary accession number(s): Q31137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.