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P06340

- DOA_HUMAN

UniProt

P06340 - DOA_HUMAN

Protein

HLA class II histocompatibility antigen, DO alpha chain

Gene

HLA-DOA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

    GO - Molecular functioni

    1. MHC class II protein complex binding Source: UniProt
    2. MHC class II receptor activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. immune response Source: InterPro
    3. negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProt
    4. regulation of T cell differentiation Source: Ensembl
    5. signal transduction Source: GOC

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DO alpha chain
    Alternative name(s):
    MHC DN-alpha
    MHC DZ alpha
    MHC class II antigen DOA
    Gene namesi
    Name:HLA-DOA
    Synonyms:HLA-DNA, HLA-DZA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4936. HLA-DOA.

    Subcellular locationi

    Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein
    Note: Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: Reactome
    4. MHC class II protein complex Source: UniProt
    5. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane, MHC II

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35060.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 250225HLA class II histocompatibility antigen, DO alpha chainPRO_0000018962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 189PROSITE-ProRule annotation
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP06340.
    PRIDEiP06340.

    Expressioni

    Gene expression databases

    ArrayExpressiP06340.
    BgeeiP06340.
    GenevestigatoriP06340.

    Organism-specific databases

    HPAiHPA045038.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

    Protein-protein interaction databases

    BioGridi109356. 1 interaction.
    DIPiDIP-60116N.
    MINTiMINT-6630142.

    Structurei

    Secondary structure

    1
    250
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 4012
    Helixi42 – 443
    Beta strandi45 – 528
    Beta strandi55 – 617
    Turni62 – 654
    Beta strandi66 – 716
    Helixi72 – 743
    Beta strandi77 – 804
    Helixi87 – 948
    Helixi96 – 1027
    Beta strandi114 – 1218
    Beta strandi129 – 14113
    Beta strandi144 – 1496
    Beta strandi152 – 1543
    Beta strandi171 – 1799
    Beta strandi187 – 1926
    Beta strandi196 – 1983
    Beta strandi200 – 2045

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I0PX-ray3.20C/G27-207[»]
    ProteinModelPortaliP06340.
    SMRiP06340. Positions 27-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 217192ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25010CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei218 – 24023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 20593Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 11085Alpha-1Add
    BLAST
    Regioni111 – 20494Alpha-2Add
    BLAST
    Regioni205 – 21713Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45645.
    HOVERGENiHBG006862.
    InParanoidiP06340.
    KOiK06752.
    OMAiMETLVCA.
    PhylomeDBiP06340.
    TreeFamiTF333797.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06340-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH    50
    EFDEEQLFSV DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV 100
    ERSNRSRAIN VPPRVTVLPK SRVELGQPNI LICIVDNIFP PVINITWLRN 150
    GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV PSAEDVYDCQ VEHWGLDAPL 200
    LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR 250
    Length:250
    Mass (Da):27,599
    Last modified:January 1, 1988 - v1
    Checksum:iFA9482197A02AC85
    GO

    Polymorphismi

    The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti99 – 991L → V in allele DOA*01:03.
    Corresponds to variant rs41542323 [ dbSNP | Ensembl ].
    VAR_058126
    Natural varianti105 – 1051R → C in allele DOA*01:02.
    Corresponds to variant rs11575906 [ dbSNP | Ensembl ].
    VAR_058127

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02882 Genomic DNA. Translation: CAA26635.1.
    M26039 mRNA. Translation: AAA59716.1.
    M31525 mRNA. Translation: AAA60075.1.
    AY947479 mRNA. Translation: AAX49509.1.
    AY947480 mRNA. Translation: AAX49510.1.
    AY947481 mRNA. Translation: AAX49511.1.
    AK290714 mRNA. Translation: BAF83403.1.
    AK313551 mRNA. Translation: BAG36327.1.
    Z81310 Genomic DNA. Translation: CAB03594.1.
    AL662845 Genomic DNA. Translation: CAI17494.1.
    AL645931 Genomic DNA. Translation: CAI18036.1.
    AL805913 Genomic DNA. Translation: CAI18546.1.
    BX005422 Genomic DNA. Translation: CAM26122.1.
    CR759829 Genomic DNA. Translation: CAP58470.1.
    CR936909 Genomic DNA. Translation: CAQ07150.1.
    CR759795 Genomic DNA. Translation: CAQ07430.1.
    CH471081 Genomic DNA. Translation: EAX03668.1.
    BC013183 mRNA. Translation: AAH13183.1.
    AB005991 Genomic DNA. Translation: BAA81787.1.
    AB005992 Genomic DNA. Translation: BAA81788.1.
    AB005993 Genomic DNA. Translation: BAA81789.1.
    AB005994 Genomic DNA. Translation: BAA81790.1.
    AB005995 Genomic DNA. Translation: BAA81791.1.
    AB005996 Genomic DNA. Translation: BAA81792.1.
    AB005997 Genomic DNA. Translation: BAA81793.1.
    AB005998 Genomic DNA. Translation: BAA81794.1.
    CCDSiCCDS4763.1.
    PIRiA02216. HLHUDZ.
    RefSeqiNP_002110.1. NM_002119.3.
    UniGeneiHs.631991.

    Genome annotation databases

    EnsembliENST00000229829; ENSP00000229829; ENSG00000204252.
    ENST00000383226; ENSP00000372713; ENSG00000206292.
    ENST00000426070; ENSP00000401504; ENSG00000231558.
    ENST00000426685; ENSP00000397945; ENSG00000232957.
    ENST00000434335; ENSP00000416448; ENSG00000232962.
    ENST00000438987; ENSP00000395737; ENSG00000230141.
    ENST00000452598; ENSP00000398819; ENSG00000235744.
    GeneIDi3111.
    KEGGihsa:3111.
    UCSCiuc003ocr.3. human.

    Polymorphism databases

    DMDMi122210.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02882 Genomic DNA. Translation: CAA26635.1 .
    M26039 mRNA. Translation: AAA59716.1 .
    M31525 mRNA. Translation: AAA60075.1 .
    AY947479 mRNA. Translation: AAX49509.1 .
    AY947480 mRNA. Translation: AAX49510.1 .
    AY947481 mRNA. Translation: AAX49511.1 .
    AK290714 mRNA. Translation: BAF83403.1 .
    AK313551 mRNA. Translation: BAG36327.1 .
    Z81310 Genomic DNA. Translation: CAB03594.1 .
    AL662845 Genomic DNA. Translation: CAI17494.1 .
    AL645931 Genomic DNA. Translation: CAI18036.1 .
    AL805913 Genomic DNA. Translation: CAI18546.1 .
    BX005422 Genomic DNA. Translation: CAM26122.1 .
    CR759829 Genomic DNA. Translation: CAP58470.1 .
    CR936909 Genomic DNA. Translation: CAQ07150.1 .
    CR759795 Genomic DNA. Translation: CAQ07430.1 .
    CH471081 Genomic DNA. Translation: EAX03668.1 .
    BC013183 mRNA. Translation: AAH13183.1 .
    AB005991 Genomic DNA. Translation: BAA81787.1 .
    AB005992 Genomic DNA. Translation: BAA81788.1 .
    AB005993 Genomic DNA. Translation: BAA81789.1 .
    AB005994 Genomic DNA. Translation: BAA81790.1 .
    AB005995 Genomic DNA. Translation: BAA81791.1 .
    AB005996 Genomic DNA. Translation: BAA81792.1 .
    AB005997 Genomic DNA. Translation: BAA81793.1 .
    AB005998 Genomic DNA. Translation: BAA81794.1 .
    CCDSi CCDS4763.1.
    PIRi A02216. HLHUDZ.
    RefSeqi NP_002110.1. NM_002119.3.
    UniGenei Hs.631991.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I0P X-ray 3.20 C/G 27-207 [» ]
    ProteinModelPortali P06340.
    SMRi P06340. Positions 27-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109356. 1 interaction.
    DIPi DIP-60116N.
    MINTi MINT-6630142.

    Polymorphism databases

    DMDMi 122210.

    Proteomic databases

    PaxDbi P06340.
    PRIDEi P06340.

    Protocols and materials databases

    DNASUi 3111.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229829 ; ENSP00000229829 ; ENSG00000204252 .
    ENST00000383226 ; ENSP00000372713 ; ENSG00000206292 .
    ENST00000426070 ; ENSP00000401504 ; ENSG00000231558 .
    ENST00000426685 ; ENSP00000397945 ; ENSG00000232957 .
    ENST00000434335 ; ENSP00000416448 ; ENSG00000232962 .
    ENST00000438987 ; ENSP00000395737 ; ENSG00000230141 .
    ENST00000452598 ; ENSP00000398819 ; ENSG00000235744 .
    GeneIDi 3111.
    KEGGi hsa:3111.
    UCSCi uc003ocr.3. human.

    Organism-specific databases

    CTDi 3111.
    GeneCardsi GC06M032971.
    GC06Mj32894.
    GC06Mk32949.
    GC06Ml33125.
    GC06Mm33005.
    GC06Mn32900.
    GC06Mo33111.
    HGNCi HGNC:4936. HLA-DOA.
    HPAi HPA045038.
    MIMi 142930. gene.
    neXtProti NX_P06340.
    PharmGKBi PA35060.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45645.
    HOVERGENi HBG006862.
    InParanoidi P06340.
    KOi K06752.
    OMAi METLVCA.
    PhylomeDBi P06340.
    TreeFami TF333797.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.

    Miscellaneous databases

    GeneWikii HLA-DOA.
    GenomeRNAii 3111.
    NextBioi 12345.
    PROi P06340.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06340.
    Bgeei P06340.
    Genevestigatori P06340.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions."
      Trowsdale J., Kelly A.
      EMBO J. 4:2231-2237(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DOA*01:01).
    2. "Human class II DNA and DOB genes display low sequence variability."
      Jonsson A.-K., Rask L.
      Immunogenetics 29:411-413(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
    3. "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript."
      Young J.A., Trowsdale J.
      Immunogenetics 31:386-388(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
    4. "Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing."
      Moon S.-M., Gu H., Ryu H.-J., Kim J.-J., Kim H.-T., Han B.G., Kimm K., Lee J.-K., Oh B.
      Tissue Antigens 66:242-245(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DOA*01:01; DOA*01:02 AND DOA*01:03).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
      Tissue: Lung.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
      Tissue: Lymph.
    9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-250 (ALLELE DOA*01:01).
    10. Cited for: REVIEW.

    Entry informationi

    Entry nameiDOA_HUMAN
    AccessioniPrimary (citable) accession number: P06340
    Secondary accession number(s): Q58HU0
    , Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8, Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3