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Protein

HLA class II histocompatibility antigen, DO alpha chain

Gene

HLA-DOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DO alpha chain
Alternative name(s):
MHC DN-alpha
MHC DZ alpha
MHC class II antigen DOA
Gene namesi
Name:HLA-DOA
Synonyms:HLA-DNA, HLA-DZA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 6, Unplaced

Organism-specific databases

HGNCiHGNC:4936. HLA-DOA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 217192ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 24023HelicalSequence AnalysisAdd
BLAST
Topological domaini241 – 25010CytoplasmicSequence Analysis

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: Reactome
  • MHC class II protein complex Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35060.

Polymorphism and mutation databases

BioMutaiHLA-DOA.
DMDMi122210.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 250225HLA class II histocompatibility antigen, DO alpha chainPRO_0000018962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 189PROSITE-ProRule annotation
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP06340.
PRIDEiP06340.

Expressioni

Gene expression databases

BgeeiP06340.
ExpressionAtlasiP06340. baseline and differential.
GenevisibleiP06340. HS.

Organism-specific databases

HPAiHPA045038.

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10194851,EBI-307352

Protein-protein interaction databases

BioGridi109356. 3 interactions.
DIPiDIP-60116N.
IntActiP06340. 1 interaction.
MINTiMINT-6630142.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 4012Combined sources
Helixi42 – 443Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 716Combined sources
Helixi72 – 743Combined sources
Beta strandi77 – 804Combined sources
Helixi87 – 948Combined sources
Helixi96 – 1027Combined sources
Beta strandi114 – 1218Combined sources
Beta strandi129 – 14113Combined sources
Beta strandi144 – 1496Combined sources
Beta strandi152 – 1543Combined sources
Beta strandi171 – 1799Combined sources
Beta strandi187 – 1926Combined sources
Beta strandi196 – 1983Combined sources
Beta strandi200 – 2045Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20C/G27-207[»]
ProteinModelPortaliP06340.
SMRiP06340. Positions 27-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 20593Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 11085Alpha-1Add
BLAST
Regioni111 – 20494Alpha-2Add
BLAST
Regioni205 – 21713Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45645.
HOVERGENiHBG006862.
InParanoidiP06340.
KOiK06752.
OMAiMETLVCA.
PhylomeDBiP06340.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH
60 70 80 90 100
EFDEEQLFSV DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV
110 120 130 140 150
ERSNRSRAIN VPPRVTVLPK SRVELGQPNI LICIVDNIFP PVINITWLRN
160 170 180 190 200
GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV PSAEDVYDCQ VEHWGLDAPL
210 220 230 240 250
LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR
Length:250
Mass (Da):27,599
Last modified:January 1, 1988 - v1
Checksum:iFA9482197A02AC85
GO

Polymorphismi

The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991L → V in allele DOA*01:03.
Corresponds to variant rs41542323 [ dbSNP | Ensembl ].
VAR_058126
Natural varianti105 – 1051R → C in allele DOA*01:02.
Corresponds to variant rs11575906 [ dbSNP | Ensembl ].
VAR_058127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02882 Genomic DNA. Translation: CAA26635.1.
M26039 mRNA. Translation: AAA59716.1.
M31525 mRNA. Translation: AAA60075.1.
AY947479 mRNA. Translation: AAX49509.1.
AY947480 mRNA. Translation: AAX49510.1.
AY947481 mRNA. Translation: AAX49511.1.
AK290714 mRNA. Translation: BAF83403.1.
AK313551 mRNA. Translation: BAG36327.1.
Z81310 Genomic DNA. Translation: CAB03594.1.
AL662845 Genomic DNA. Translation: CAI17494.1.
AL645931 Genomic DNA. Translation: CAI18036.1.
AL805913 Genomic DNA. Translation: CAI18546.1.
BX005422 Genomic DNA. Translation: CAM26122.1.
CR759829 Genomic DNA. Translation: CAP58470.1.
CR936909 Genomic DNA. Translation: CAQ07150.1.
CR759795 Genomic DNA. Translation: CAQ07430.1.
CH471081 Genomic DNA. Translation: EAX03668.1.
BC013183 mRNA. Translation: AAH13183.1.
AB005991 Genomic DNA. Translation: BAA81787.1.
AB005992 Genomic DNA. Translation: BAA81788.1.
AB005993 Genomic DNA. Translation: BAA81789.1.
AB005994 Genomic DNA. Translation: BAA81790.1.
AB005995 Genomic DNA. Translation: BAA81791.1.
AB005996 Genomic DNA. Translation: BAA81792.1.
AB005997 Genomic DNA. Translation: BAA81793.1.
AB005998 Genomic DNA. Translation: BAA81794.1.
CCDSiCCDS4763.1.
PIRiA02216. HLHUDZ.
RefSeqiNP_002110.1. NM_002119.3.
UniGeneiHs.631991.

Genome annotation databases

EnsembliENST00000229829; ENSP00000229829; ENSG00000204252.
ENST00000383226; ENSP00000372713; ENSG00000206292.
ENST00000426070; ENSP00000401504; ENSG00000231558.
ENST00000426685; ENSP00000397945; ENSG00000232957.
ENST00000434335; ENSP00000416448; ENSG00000232962.
ENST00000438987; ENSP00000395737; ENSG00000230141.
ENST00000452598; ENSP00000398819; ENSG00000235744.
GeneIDi3111.
KEGGihsa:3111.
UCSCiuc003ocr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02882 Genomic DNA. Translation: CAA26635.1.
M26039 mRNA. Translation: AAA59716.1.
M31525 mRNA. Translation: AAA60075.1.
AY947479 mRNA. Translation: AAX49509.1.
AY947480 mRNA. Translation: AAX49510.1.
AY947481 mRNA. Translation: AAX49511.1.
AK290714 mRNA. Translation: BAF83403.1.
AK313551 mRNA. Translation: BAG36327.1.
Z81310 Genomic DNA. Translation: CAB03594.1.
AL662845 Genomic DNA. Translation: CAI17494.1.
AL645931 Genomic DNA. Translation: CAI18036.1.
AL805913 Genomic DNA. Translation: CAI18546.1.
BX005422 Genomic DNA. Translation: CAM26122.1.
CR759829 Genomic DNA. Translation: CAP58470.1.
CR936909 Genomic DNA. Translation: CAQ07150.1.
CR759795 Genomic DNA. Translation: CAQ07430.1.
CH471081 Genomic DNA. Translation: EAX03668.1.
BC013183 mRNA. Translation: AAH13183.1.
AB005991 Genomic DNA. Translation: BAA81787.1.
AB005992 Genomic DNA. Translation: BAA81788.1.
AB005993 Genomic DNA. Translation: BAA81789.1.
AB005994 Genomic DNA. Translation: BAA81790.1.
AB005995 Genomic DNA. Translation: BAA81791.1.
AB005996 Genomic DNA. Translation: BAA81792.1.
AB005997 Genomic DNA. Translation: BAA81793.1.
AB005998 Genomic DNA. Translation: BAA81794.1.
CCDSiCCDS4763.1.
PIRiA02216. HLHUDZ.
RefSeqiNP_002110.1. NM_002119.3.
UniGeneiHs.631991.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20C/G27-207[»]
ProteinModelPortaliP06340.
SMRiP06340. Positions 27-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109356. 3 interactions.
DIPiDIP-60116N.
IntActiP06340. 1 interaction.
MINTiMINT-6630142.

Polymorphism and mutation databases

BioMutaiHLA-DOA.
DMDMi122210.

Proteomic databases

PaxDbiP06340.
PRIDEiP06340.

Protocols and materials databases

DNASUi3111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229829; ENSP00000229829; ENSG00000204252.
ENST00000383226; ENSP00000372713; ENSG00000206292.
ENST00000426070; ENSP00000401504; ENSG00000231558.
ENST00000426685; ENSP00000397945; ENSG00000232957.
ENST00000434335; ENSP00000416448; ENSG00000232962.
ENST00000438987; ENSP00000395737; ENSG00000230141.
ENST00000452598; ENSP00000398819; ENSG00000235744.
GeneIDi3111.
KEGGihsa:3111.
UCSCiuc003ocr.3. human.

Organism-specific databases

CTDi3111.
GeneCardsiGC06M032971.
GC06Mj32894.
GC06Mk32949.
GC06Ml33125.
GC06Mm33005.
GC06Mn32900.
GC06Mo33111.
HGNCiHGNC:4936. HLA-DOA.
HPAiHPA045038.
MIMi142930. gene.
neXtProtiNX_P06340.
PharmGKBiPA35060.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45645.
HOVERGENiHBG006862.
InParanoidiP06340.
KOiK06752.
OMAiMETLVCA.
PhylomeDBiP06340.
TreeFamiTF333797.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.

Miscellaneous databases

ChiTaRSiHLA-DOA. human.
GeneWikiiHLA-DOA.
GenomeRNAii3111.
NextBioi12345.
PROiP06340.
SOURCEiSearch...

Gene expression databases

BgeeiP06340.
ExpressionAtlasiP06340. baseline and differential.
GenevisibleiP06340. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions."
    Trowsdale J., Kelly A.
    EMBO J. 4:2231-2237(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DOA*01:01).
  2. "Human class II DNA and DOB genes display low sequence variability."
    Jonsson A.-K., Rask L.
    Immunogenetics 29:411-413(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
  3. "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript."
    Young J.A., Trowsdale J.
    Immunogenetics 31:386-388(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
  4. "Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing."
    Moon S.-M., Gu H., Ryu H.-J., Kim J.-J., Kim H.-T., Han B.G., Kimm K., Lee J.-K., Oh B.
    Tissue Antigens 66:242-245(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DOA*01:01; DOA*01:02 AND DOA*01:03).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
    Tissue: Lung.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
    Tissue: Lymph.
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-250 (ALLELE DOA*01:01).
  10. Cited for: REVIEW.

Entry informationi

Entry nameiDOA_HUMAN
AccessioniPrimary (citable) accession number: P06340
Secondary accession number(s): Q58HU0
, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8, Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 24, 2015
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.