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P06339

- HA15_MOUSE

UniProt

P06339 - HA15_MOUSE

Protein

H-2 class I histocompatibility antigen, D-37 alpha chain

Gene

H2-T23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Source: MGI
    2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    3. immune response Source: InterPro
    4. inner ear development Source: MGI
    5. positive regulation of T cell mediated cytotoxicity Source: MGI

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_197102. ER-Phagosome pathway.
    REACT_198660. Interferon gamma signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199112. Endosomal/Vacuolar pathway.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H-2 class I histocompatibility antigen, D-37 alpha chain
    Gene namesi
    Name:H2-T23
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:95957. H2-T23.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    2. MHC class I protein complex Source: UniProtKB-KW
    3. phagocytic vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 357337H-2 class I histocompatibility antigen, D-37 alpha chainPRO_0000018927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 184PROSITE-ProRule annotation
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 279PROSITE-ProRule annotation
    Modified residuei347 – 3471Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP06339.
    PRIDEiP06339.

    PTM databases

    PhosphoSiteiP06339.

    Expressioni

    Gene expression databases

    ArrayExpressiP06339.
    BgeeiP06339.
    CleanExiMM_H2-T23.
    GenevestigatoriP06339.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

    Structurei

    Secondary structure

    1
    357
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 3210
    Beta strandi41 – 488
    Beta strandi51 – 577
    Beta strandi60 – 623
    Beta strandi66 – 694
    Helixi70 – 745
    Helixi77 – 10529
    Beta strandi114 – 12310
    Beta strandi129 – 13810
    Beta strandi141 – 1466
    Beta strandi153 – 1553
    Helixi158 – 16912
    Helixi172 – 18110
    Helixi183 – 19412
    Helixi196 – 1994
    Beta strandi206 – 21510
    Beta strandi218 – 23114
    Beta strandi234 – 2396
    Beta strandi257 – 2593
    Beta strandi261 – 27010
    Helixi274 – 2763
    Beta strandi277 – 2826
    Beta strandi290 – 2923

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VJ6X-ray1.90A21-297[»]
    ProteinModelPortaliP06339.
    SMRiP06339. Positions 21-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 304284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 35730CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei305 – 32723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini205 – 29389Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 11090Alpha-1Add
    BLAST
    Regioni111 – 20292Alpha-2Add
    BLAST
    Regioni203 – 29492Alpha-3Add
    BLAST
    Regioni295 – 30410Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOGENOMiHOG000296917.
    HOVERGENiHBG016709.
    InParanoidiP06339.
    KOiK06751.
    OMAiWTANDIA.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiP06339.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06339-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD    50
    TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT 100
    LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL 150
    RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ 200
    RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL 250
    VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST 300
    VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT 350
    SDWPQKA 357
    Length:357
    Mass (Da):40,875
    Last modified:January 1, 1988 - v1
    Checksum:i62139862B099D411
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11284 mRNA. Translation: AAA39693.1.
    Y00629 Genomic DNA. Translation: CAA68665.1.
    CCDSiCCDS28715.1.
    PIRiA02205. HLMS37.
    RefSeqiNP_034528.1. NM_010398.3.
    UniGeneiMm.439648.
    Mm.441651.

    Genome annotation databases

    EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
    GeneIDi15040.
    KEGGimmu:15040.
    UCSCiuc008cjr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11284 mRNA. Translation: AAA39693.1 .
    Y00629 Genomic DNA. Translation: CAA68665.1 .
    CCDSi CCDS28715.1.
    PIRi A02205. HLMS37.
    RefSeqi NP_034528.1. NM_010398.3.
    UniGenei Mm.439648.
    Mm.441651.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VJ6 X-ray 1.90 A 21-297 [» ]
    ProteinModelPortali P06339.
    SMRi P06339. Positions 21-297.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P06339.

    Proteomic databases

    PaxDbi P06339.
    PRIDEi P06339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102678 ; ENSMUSP00000099739 ; ENSMUSG00000067212 .
    GeneIDi 15040.
    KEGGi mmu:15040.
    UCSCi uc008cjr.1. mouse.

    Organism-specific databases

    CTDi 15040.
    MGIi MGI:95957. H2-T23.

    Phylogenomic databases

    eggNOGi NOG42056.
    HOGENOMi HOG000296917.
    HOVERGENi HBG016709.
    InParanoidi P06339.
    KOi K06751.
    OMAi WTANDIA.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi P06339.
    TreeFami TF336617.

    Enzyme and pathway databases

    Reactomei REACT_197102. ER-Phagosome pathway.
    REACT_198660. Interferon gamma signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199112. Endosomal/Vacuolar pathway.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    NextBioi 287452.
    PROi P06339.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06339.
    Bgeei P06339.
    CleanExi MM_H2-T23.
    Genevestigatori P06339.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver."
      Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P.
      Cell 41:469-478(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    2. "A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types."
      Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, Hood L.E., Kourilsky P.
      J. Exp. Med. 166:341-361(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Sperm.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHA15_MOUSE
    AccessioniPrimary (citable) accession number: P06339
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3