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Protein

H-2 class I histocompatibility antigen, D-37 alpha chain

Gene

H2-T23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene namesi
Name:H2-T23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95957. H2-T23.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 304ExtracellularSequence analysisAdd BLAST284
Transmembranei305 – 327HelicalSequence analysisAdd BLAST23
Topological domaini328 – 357CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001892721 – 357H-2 class I histocompatibility antigen, D-37 alpha chainAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 184PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi223 ↔ 279PROSITE-ProRule annotation
Modified residuei347PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP06339.
PaxDbiP06339.
PRIDEiP06339.

PTM databases

iPTMnetiP06339.
PhosphoSitePlusiP06339.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067212.
CleanExiMM_H2-T23.
ExpressionAtlasiP06339. baseline and differential.
GenevisibleiP06339. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739.

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 32Combined sources10
Beta strandi41 – 48Combined sources8
Beta strandi51 – 57Combined sources7
Beta strandi60 – 62Combined sources3
Beta strandi66 – 69Combined sources4
Helixi70 – 74Combined sources5
Helixi77 – 105Combined sources29
Beta strandi114 – 123Combined sources10
Beta strandi129 – 138Combined sources10
Beta strandi141 – 146Combined sources6
Beta strandi153 – 155Combined sources3
Helixi158 – 169Combined sources12
Helixi172 – 181Combined sources10
Helixi183 – 194Combined sources12
Helixi196 – 199Combined sources4
Beta strandi206 – 215Combined sources10
Beta strandi218 – 231Combined sources14
Beta strandi234 – 239Combined sources6
Beta strandi257 – 259Combined sources3
Beta strandi261 – 270Combined sources10
Helixi274 – 276Combined sources3
Beta strandi277 – 282Combined sources6
Beta strandi290 – 292Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339.
SMRiP06339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 293Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 110Alpha-1Add BLAST90
Regioni111 – 202Alpha-2Add BLAST92
Regioni203 – 294Alpha-3Add BLAST92
Regioni295 – 304Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP06339.
KOiK06751.
OMAiWTANDIA.
OrthoDBiEOG091G09OH.
PhylomeDBiP06339.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD
60 70 80 90 100
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT
110 120 130 140 150
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL
160 170 180 190 200
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ
210 220 230 240 250
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL
260 270 280 290 300
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST
310 320 330 340 350
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT

SDWPQKA
Length:357
Mass (Da):40,875
Last modified:January 1, 1988 - v1
Checksum:i62139862B099D411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
CCDSiCCDS28715.1.
PIRiA02205. HLMS37.
RefSeqiNP_034528.1. NM_010398.3.
UniGeneiMm.439648.
Mm.441651.

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneIDi15040.
KEGGimmu:15040.
UCSCiuc008cjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
CCDSiCCDS28715.1.
PIRiA02205. HLMS37.
RefSeqiNP_034528.1. NM_010398.3.
UniGeneiMm.439648.
Mm.441651.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339.
SMRiP06339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739.

PTM databases

iPTMnetiP06339.
PhosphoSitePlusiP06339.

Proteomic databases

EPDiP06339.
PaxDbiP06339.
PRIDEiP06339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneIDi15040.
KEGGimmu:15040.
UCSCiuc008cjr.1. mouse.

Organism-specific databases

CTDi15040.
MGIiMGI:95957. H2-T23.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP06339.
KOiK06751.
OMAiWTANDIA.
OrthoDBiEOG091G09OH.
PhylomeDBiP06339.
TreeFamiTF336617.

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiP06339.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067212.
CleanExiMM_H2-T23.
ExpressionAtlasiP06339. baseline and differential.
GenevisibleiP06339. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA15_MOUSE
AccessioniPrimary (citable) accession number: P06339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.