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Protein

H-2 class I histocompatibility antigen, D-37 alpha chain

Gene

H2-T23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_308964. ER-Phagosome pathway.
REACT_339401. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_341075. ER-Phagosome pathway.
REACT_342269. Endosomal/Vacuolar pathway.
REACT_349056. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene namesi
Name:H2-T23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95957. H2-T23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 304284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei305 – 32723HelicalSequence AnalysisAdd
BLAST
Topological domaini328 – 35730CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 357337H-2 class I histocompatibility antigen, D-37 alpha chainPRO_0000018927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi121 ↔ 184PROSITE-ProRule annotation
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 279PROSITE-ProRule annotation
Modified residuei339 – 3391PhosphotyrosineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei347 – 3471Phosphoserine1 Publication
Modified residuei351 – 3511PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06339.
PRIDEiP06339.

PTM databases

PhosphoSiteiP06339.

Expressioni

Gene expression databases

BgeeiP06339.
CleanExiMM_H2-T23.
ExpressionAtlasiP06339. baseline and differential.
GenevisibleiP06339. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739.

Structurei

Secondary structure

1
357
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 3210Combined sources
Beta strandi41 – 488Combined sources
Beta strandi51 – 577Combined sources
Beta strandi60 – 623Combined sources
Beta strandi66 – 694Combined sources
Helixi70 – 745Combined sources
Helixi77 – 10529Combined sources
Beta strandi114 – 12310Combined sources
Beta strandi129 – 13810Combined sources
Beta strandi141 – 1466Combined sources
Beta strandi153 – 1553Combined sources
Helixi158 – 16912Combined sources
Helixi172 – 18110Combined sources
Helixi183 – 19412Combined sources
Helixi196 – 1994Combined sources
Beta strandi206 – 21510Combined sources
Beta strandi218 – 23114Combined sources
Beta strandi234 – 2396Combined sources
Beta strandi257 – 2593Combined sources
Beta strandi261 – 27010Combined sources
Helixi274 – 2763Combined sources
Beta strandi277 – 2826Combined sources
Beta strandi290 – 2923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339.
SMRiP06339. Positions 21-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 29389Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 11090Alpha-1Add
BLAST
Regioni111 – 20292Alpha-2Add
BLAST
Regioni203 – 29492Alpha-3Add
BLAST
Regioni295 – 30410Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP06339.
KOiK06751.
OMAiGYCQEAY.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP06339.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD
60 70 80 90 100
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT
110 120 130 140 150
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL
160 170 180 190 200
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ
210 220 230 240 250
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL
260 270 280 290 300
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST
310 320 330 340 350
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT

SDWPQKA
Length:357
Mass (Da):40,875
Last modified:January 1, 1988 - v1
Checksum:i62139862B099D411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
CCDSiCCDS28715.1.
PIRiA02205. HLMS37.
RefSeqiNP_034528.1. NM_010398.3.
UniGeneiMm.439648.
Mm.441651.

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneIDi15040.
KEGGimmu:15040.
UCSCiuc008cjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
CCDSiCCDS28715.1.
PIRiA02205. HLMS37.
RefSeqiNP_034528.1. NM_010398.3.
UniGeneiMm.439648.
Mm.441651.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339.
SMRiP06339. Positions 21-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739.

PTM databases

PhosphoSiteiP06339.

Proteomic databases

PaxDbiP06339.
PRIDEiP06339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneIDi15040.
KEGGimmu:15040.
UCSCiuc008cjr.1. mouse.

Organism-specific databases

CTDi15040.
MGIiMGI:95957. H2-T23.

Phylogenomic databases

eggNOGiNOG42056.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP06339.
KOiK06751.
OMAiGYCQEAY.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP06339.
TreeFamiTF336617.

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_308964. ER-Phagosome pathway.
REACT_339401. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_341075. ER-Phagosome pathway.
REACT_342269. Endosomal/Vacuolar pathway.
REACT_349056. Interferon gamma signaling.

Miscellaneous databases

NextBioi287452.
PROiP06339.
SOURCEiSearch...

Gene expression databases

BgeeiP06339.
CleanExiMM_H2-T23.
ExpressionAtlasiP06339. baseline and differential.
GenevisibleiP06339. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver."
    Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P.
    Cell 41:469-478(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  2. "A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types."
    Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, Hood L.E., Kourilsky P.
    J. Exp. Med. 166:341-361(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Sperm.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHA15_MOUSE
AccessioniPrimary (citable) accession number: P06339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 22, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.