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P06339 (HA15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene names
Name:H2-T23
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 357337H-2 class I histocompatibility antigen, D-37 alpha chain
PRO_0000018927

Regions

Topological domain21 – 304284Extracellular Potential
Transmembrane305 – 32723Helical; Potential
Topological domain328 – 35730Cytoplasmic Potential
Domain205 – 29389Ig-like C1-type
Region21 – 11090Alpha-1
Region111 – 20292Alpha-2
Region203 – 29492Alpha-3
Region295 – 30410Connecting peptide

Amino acid modifications

Modified residue3471Phosphoserine Ref.3
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 184 By similarity
Disulfide bond223 ↔ 279 By similarity

Secondary structure

............................................. 357
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P06339 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 62139862B099D411

FASTA35740,875
        10         20         30         40         50         60 
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD TQFVRFDSDA 

        70         80         90        100        110        120 
ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT LLGYYNQSND ESHTLQWMYG 

       130        140        150        160        170        180 
CDVGPDGRLL RGYCQEAYDG QDYISLNEDL RSWTANDIAS QISKHKSEAV DEAHQQRAYL 

       190        200        210        220        230        240 
QGPCVEWLHR YLRLGNETLQ RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN 

       250        260        270        280        290        300 
GEELTQDMEL VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST 

       310        320        330        340        350 
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT SDWPQKA 

« Hide

References

« Hide 'large scale' references
[1]"Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver."
Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P.
Cell 41:469-478(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2.
[2]"A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types."
Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, Hood L.E., Kourilsky P.
J. Exp. Med. 166:341-361(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Sperm.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
PIRHLMS37. A02205.
RefSeqNP_034528.1. NM_010398.3.
UniGeneMm.439648.
Mm.441651.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortalP06339.
SMRP06339. Positions 21-297.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP06339.

Proteomic databases

PaxDbP06339.
PRIDEP06339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneID15040.
KEGGmmu:15040.
UCSCuc008cjr.1. mouse.

Organism-specific databases

CTD15040.
MGIMGI:95957. H2-T23.

Phylogenomic databases

eggNOGNOG42056.
HOGENOMHOG000296917.
HOVERGENHBG016709.
InParanoidP06339.
KOK06751.
OMACQEAYDG.
OrthoDBEOG7JT6WQ.
PhylomeDBP06339.
TreeFamTF336617.

Enzyme and pathway databases

ReactomeREACT_102124. Immune System.
REACT_98458. Immune System.

Gene expression databases

ArrayExpressP06339.
BgeeP06339.
CleanExMM_H2-T23.
GenevestigatorP06339.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287452.
PROP06339.
SOURCESearch...

Entry information

Entry nameHA15_MOUSE
AccessionPrimary (citable) accession number: P06339
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot