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P06339

- HA15_MOUSE

UniProt

P06339 - HA15_MOUSE

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Protein
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene
H2-T23
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: RefGenome
  2. receptor binding Source: RefGenome

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Source: MGI
  2. antigen processing and presentation of peptide antigen via MHC class I Source: RefGenome
  3. immune response Source: InterPro
  4. inner ear development Source: MGI
  5. positive regulation of T cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_197102. ER-Phagosome pathway.
REACT_198660. Interferon gamma signaling.
REACT_199105. ER-Phagosome pathway.
REACT_199112. Endosomal/Vacuolar pathway.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene namesi
Name:H2-T23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:95957. H2-T23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 304284Extracellular Reviewed prediction
Add
BLAST
Transmembranei305 – 32723Helical; Reviewed prediction
Add
BLAST
Topological domaini328 – 35730Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. MHC class I protein complex Source: UniProtKB-KW
  2. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  3. phagocytic vesicle membrane Source: Reactome
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 357337H-2 class I histocompatibility antigen, D-37 alpha chain
PRO_0000018927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi121 ↔ 184 By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 279 By similarity
Modified residuei347 – 3471Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06339.
PRIDEiP06339.

PTM databases

PhosphoSiteiP06339.

Expressioni

Gene expression databases

ArrayExpressiP06339.
BgeeiP06339.
CleanExiMM_H2-T23.
GenevestigatoriP06339.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 3210
Beta strandi41 – 488
Beta strandi51 – 577
Beta strandi60 – 623
Beta strandi66 – 694
Helixi70 – 745
Helixi77 – 10529
Beta strandi114 – 12310
Beta strandi129 – 13810
Beta strandi141 – 1466
Beta strandi153 – 1553
Helixi158 – 16912
Helixi172 – 18110
Helixi183 – 19412
Helixi196 – 1994
Beta strandi206 – 21510
Beta strandi218 – 23114
Beta strandi234 – 2396
Beta strandi257 – 2593
Beta strandi261 – 27010
Helixi274 – 2763
Beta strandi277 – 2826
Beta strandi290 – 2923

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339.
SMRiP06339. Positions 21-297.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 29389Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 11090Alpha-1
Add
BLAST
Regioni111 – 20292Alpha-2
Add
BLAST
Regioni203 – 29492Alpha-3
Add
BLAST
Regioni295 – 30410Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP06339.
KOiK06751.
OMAiWTANDIA.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP06339.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06339-1 [UniParc]FASTAAdd to Basket

« Hide

MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD    50
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT 100
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL 150
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ 200
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL 250
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST 300
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT 350
SDWPQKA 357
Length:357
Mass (Da):40,875
Last modified:January 1, 1988 - v1
Checksum:i62139862B099D411
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.
CCDSiCCDS28715.1.
PIRiA02205. HLMS37.
RefSeqiNP_034528.1. NM_010398.3.
UniGeneiMm.439648.
Mm.441651.

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.
GeneIDi15040.
KEGGimmu:15040.
UCSCiuc008cjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11284 mRNA. Translation: AAA39693.1 .
Y00629 Genomic DNA. Translation: CAA68665.1 .
CCDSi CCDS28715.1.
PIRi A02205. HLMS37.
RefSeqi NP_034528.1. NM_010398.3.
UniGenei Mm.439648.
Mm.441651.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VJ6 X-ray 1.90 A 21-297 [» ]
ProteinModelPortali P06339.
SMRi P06339. Positions 21-297.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P06339.

Proteomic databases

PaxDbi P06339.
PRIDEi P06339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102678 ; ENSMUSP00000099739 ; ENSMUSG00000067212 .
GeneIDi 15040.
KEGGi mmu:15040.
UCSCi uc008cjr.1. mouse.

Organism-specific databases

CTDi 15040.
MGIi MGI:95957. H2-T23.

Phylogenomic databases

eggNOGi NOG42056.
HOGENOMi HOG000296917.
HOVERGENi HBG016709.
InParanoidi P06339.
KOi K06751.
OMAi WTANDIA.
OrthoDBi EOG7JT6WQ.
PhylomeDBi P06339.
TreeFami TF336617.

Enzyme and pathway databases

Reactomei REACT_197102. ER-Phagosome pathway.
REACT_198660. Interferon gamma signaling.
REACT_199105. ER-Phagosome pathway.
REACT_199112. Endosomal/Vacuolar pathway.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

NextBioi 287452.
PROi P06339.
SOURCEi Search...

Gene expression databases

ArrayExpressi P06339.
Bgeei P06339.
CleanExi MM_H2-T23.
Genevestigatori P06339.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver."
    Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P.
    Cell 41:469-478(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  2. "A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types."
    Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, Hood L.E., Kourilsky P.
    J. Exp. Med. 166:341-361(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Sperm.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHA15_MOUSE
AccessioniPrimary (citable) accession number: P06339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi