P06339 (HA15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain

Gene names

Name:

H2-T23

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Inferred from direct assay PubMed 1538753. Source: MGI antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro inner ear development Inferred from direct assay PubMed 21795542. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from direct assay PubMed 1538753. Source: MGI
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Potential

Chain

21 – 357

337

H-2 class I histocompatibility antigen, D-37 alpha chain

PRO_0000018927

Regions

Topological domain

21 – 304

284

Extracellular Potential

Transmembrane

305 – 327

23

Helical; Potential

Topological domain

328 – 357

30

Cytoplasmic Potential

Domain

205 – 293

89

Ig-like C1-type

Region

21 – 110

90

Alpha-1

Region

111 – 202

92

Alpha-2

Region

203 – 294

92

Alpha-3

Region

295 – 304

10

Connecting peptide

Amino acid modifications

Modified residue

347

1

Phosphoserine Ref.3

Glycosylation

106

1

N-linked (GlcNAc...) Potential

Glycosylation

196

1

N-linked (GlcNAc...) Potential

Disulfide bond

121 ↔ 184

By similarity

Disulfide bond

223 ↔ 279

By similarity

Secondary structure

1

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357

Helix Strand Turn

Details...

Beta strand

23 – 32

10

Beta strand

41 – 48

8

Beta strand

51 – 57

7

Beta strand

60 – 62

3

Beta strand

66 – 69

4

Helix

70 – 74

5

Helix

77 – 105

29

Beta strand

114 – 123

10

Beta strand

129 – 138

10

Beta strand

141 – 146

6

Beta strand

153 – 155

3

Helix

158 – 169

12

Helix

172 – 181

10

Helix

183 – 194

12

Helix

196 – 199

4

Beta strand

206 – 215

10

Beta strand

218 – 231

14

Beta strand

234 – 239

6

Beta strand

257 – 259

3

Beta strand

261 – 270

10

Helix

274 – 276

3

Beta strand

277 – 282

6

Beta strand

290 – 292

3

Sequences

	Sequence		Length	Mass (Da)
	P06339 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 62139862B099D411	FASTA	357	40,875
	10 20 30 40 50 60 MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD TQFVRFDSDA 70 80 90 100 110 120 ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT LLGYYNQSND ESHTLQWMYG 130 140 150 160 170 180 CDVGPDGRLL RGYCQEAYDG QDYISLNEDL RSWTANDIAS QISKHKSEAV DEAHQQRAYL 190 200 210 220 230 240 QGPCVEWLHR YLRLGNETLQ RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN 250 260 270 280 290 300 GEELTQDMEL VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST 310 320 330 340 350 VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT SDWPQKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver." Lalanne J.-L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P. Cell 41:469-478(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2.
[2]	"A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types." Transy C., Nash S.R., David-Watine B., Cochet M., Hunt S.W. III, Hood L.E., Kourilsky P. J. Exp. Med. 166:341-361(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Sperm.
[3]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M11284 mRNA. Translation: AAA39693.1.
Y00629 Genomic DNA. Translation: CAA68665.1.

IPI

IPI00322542.

PIR

HLMS37. A02205.

RefSeq

NP_034528.1. NM_010398.3.

UniGene

Mm.439648.
Mm.441651.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3VJ6	X-ray	1.90	A	21-297	[»]

ProteinModelPortal

P06339.

SMR

P06339. Positions 21-297.

ModBase

Search...

PTM databases

PhosphoSite

P06339.

Proteomic databases

PaxDb

P06339.

PRIDE

P06339.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212.

GeneID

15040.

KEGG

mmu:15040.

Organism-specific databases

CTD

15040.

MGI

MGI:95957. H2-T23.

Phylogenomic databases

eggNOG

NOG42056.

HOGENOM

HOG000296917.

HOVERGEN

HBG016709.

InParanoid

P06339.

KO

K06751.

OMA

ANDIASQ.

OrthoDB

EOG4F4SBG.

Enzyme and pathway databases

Reactome

REACT_102124. Immune System.
REACT_107772. Immune System.

Gene expression databases

ArrayExpress

P06339.

Bgee

P06339.

CleanEx

MM_H2-T23.

Genevestigator

P06339.

GermOnline

ENSMUSG00000067212. Mus musculus.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

287452.

SOURCE

Search...

Entry information

Entry name

HA15_MOUSE

Accession

Primary (citable) accession number: P06339

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program