Reviewed, UniProtKB/Swiss-Prot P06327 (HVM52_MOUSE)

Names and origin

Protein names	Recommended name:     Ig heavy chain V region VH558 A1/A4
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 117	98	Ig heavy chain V region VH558 A1/A4		PRO_0000015235
Regions
	Region	20 – 49	30	Framework-1
	Region	50 – 54	5	Complementarity-determining-1
	Region	55 – 68	14	Framework-2
	Region	69 – 85	17	Complementarity-determining-2
	Region	86 – 117	32	Framework-3
Amino acid modifications
	Disulfide bond	41 ↔ 115		By similarity
Experimental info
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	P06327-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 8B0BC138856DFC9D	FASTA	117	12,971
	10 20 30 40 50 60 MGWRWIFLFL LSGTAGVHCQ VQLQQSGPEL VKPGALVKIS CKASGYTFTS YDINWVKQRP 70 80 90 100 110 GQGLEWIGWI YPGDGSTKYN EKFKGKATLT ADKSSSTAYM QLSSLTSENS AVYFCAR

References

[1]	"Developmentally controlled and tissue-specific expression of unrearranged VH gene segments." Yancopoulos G.D., Alt F.W. Cell 40:271-281(1985) [PubMed: 2578321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13787 mRNA. Translation: AAA38499.1.
IPI	IPI00463015.
PIR	HVMSA1. A02029.
UniGene	Mm.464351
3D structure databases
SMR	P06327. Positions 20-117.
ModBase	Search...
Protein family/group databases
IMGT	Search...
Proteomic databases
PRIDE	P06327.
Genome annotation databases
Ensembl	ENSMUST00000103551; ENSMUSP00000100332; ENSMUSG00000076742; Mus musculus. [Genome view]
Phylogenomic databases
eggNOG	maNOG23017.
HOGENOM	HBG716786.
HOVERGEN	P06327.
InParanoid	P06327.
Gene expression databases
Bgee	P06327.
Genevestigator	P06327.
GermOnline	ENSMUSG00000062033. Mus musculus.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HVM52_MOUSE

Accession

Primary (citable) accession number: P06327

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	January 19, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)