P06327 (HVM52_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig heavy chain V region VH558 A1/A4

Gene names

Name:

Gm5629

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 117	98	Ig heavy chain V region VH558 A1/A4		PRO_0000015235
Regions
	Region	20 – 49	30	Framework-1
	Region	50 – 54	5	Complementarity-determining-1
	Region	55 – 68	14	Framework-2
	Region	69 – 85	17	Complementarity-determining-2
	Region	86 – 117	32	Framework-3
Amino acid modifications
	Disulfide bond	41 ↔ 115		By similarity
Experimental info
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	P06327 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 8B0BC138856DFC9D	FASTA	117	12,971
	10 20 30 40 50 60 MGWRWIFLFL LSGTAGVHCQ VQLQQSGPEL VKPGALVKIS CKASGYTFTS YDINWVKQRP 70 80 90 100 110 GQGLEWIGWI YPGDGSTKYN EKFKGKATLT ADKSSSTAYM QLSSLTSENS AVYFCAR

References

[1]	"Developmentally controlled and tissue-specific expression of unrearranged VH gene segments." Yancopoulos G.D., Alt F.W. Cell 40:271-281(1985) [PubMed: 2578321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13787 mRNA. Translation: AAA38499.1.
IPI	IPI00463015.
PIR	HVMSA1. A02029.
UniGene	Mm.464351.
3D structure databases
ProteinModelPortal	P06327.
SMR	P06327. Positions 20-117.
ModBase	Search...
Protein-protein interaction databases
STRING	P06327.
Protein family/group databases
IMGT	Search...
Proteomic databases
PRIDE	P06327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:3644235. Gm5629.
Phylogenomic databases
eggNOG	maNOG23017.
GeneTree	ENSGT00580000081342.
HOGENOM	HBG716786.
HOVERGEN	HBG018013.
InParanoid	P06327.
OrthoDB	EOG4V6ZJ5.
Gene expression databases
Bgee	P06327.
Genevestigator	P06327.
GermOnline	ENSMUSG00000062033. Mus musculus.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

HVM52_MOUSE

Accession

Primary (citable) accession number: P06327

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	September 21, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program