P06317 (LV603_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig lambda chain V-VI region SUT
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – ›111

›111

Ig lambda chain V-VI region SUT

PRO_0000059852

Regions

Region

1 – 22

22

Framework-1

Region

23 – 35

13

Complementarity-determining-1

Region

36 – 50

15

Framework-2

Region

51 – 57

7

Complementarity-determining-2

Region

58 – 91

34

Framework-3

Region

92 – 100

9

Complementarity-determining-3

Region

101 – 111

11

Framework-4

Amino acid modifications

Disulfide bond

22 ↔ 91

By similarity

Experimental info

Non-terminal residue

111

1

Secondary structure

1

.

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111

Helix Strand Turn

Details...

Beta strand

8 – 12

5

Beta strand

18 – 27

10

Helix

29 – 31

3

Beta strand

35 – 39

5

Beta strand

46 – 50

5

Turn

51 – 53

3

Beta strand

63 – 68

6

Turn

69 – 72

4

Beta strand

73 – 78

6

Helix

83 – 85

3

Beta strand

87 – 95

9

Beta strand

98 – 101

4

Beta strand

105 – 109

5

Sequences

	Sequence		Length	Mass (Da)
	P06317 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 0941DD547D983598	FASTA	111	12,247
	10 20 30 40 50 60 DFMLTQPHSV SESPGKTVII SCTRSDGTIA GYYVQWYQQR PGRAPTTVIF EDTQRPSGVP 70 80 90 100 110 DRFSGSIDRS SNSASLTISG LQTEDEADYY CQSYDRDHWV FGGGTKLTVL G

References

[1]	"Light chain variable region subgroups of monoclonal immunoglobulins in amyloidosis AL." Solomon A., Kyle R.A., Frangione B. (In) Glenner G.G., Osserman E.F., Benditt E.P., Calkins E., Cohen A.S., Zucker-Franklin D. (eds.); Amyloidosis, pp.449-462, Plenum Press, New York (1986) Cited for: PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00386135.

PIR

L6HUST. A01988.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CD0	X-ray	1.90	A/B	2-111	[»]
1PEW	X-ray	1.60	A/B	2-111	[»]
2CD0	X-ray	1.80	A/B	4-111	[»]

ProteinModelPortal

P06317.

SMR

P06317. Positions 1-111.

ModBase

Search...

Polymorphism databases

DMDM

126574.

Proteomic databases

PRIDE

P06317.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG018013.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Genevestigator

P06317.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

LV603_HUMAN

Accession

Primary (citable) accession number: P06317

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.