P06311 (KV311_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-III region IARC/BL41
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 128	108	Ig kappa chain V-III region IARC/BL41		PRO_0000015178
Regions
	Region	21 – 43	23	Framework-1
	Region	44 – 54	11	Complementarity-determining-1
	Region	55 – 69	15	Framework-2
	Region	70 – 76	7	Complementarity-determining-2
	Region	77 – 108	32	Framework-3
	Region	109 – 117	9	Complementarity-determining-3
	Region	118 – 128	11	JK1 segment
Amino acid modifications
	Disulfide bond	43 ↔ 108		By similarity
Experimental info
	Non-terminal residue	128	1

Sequences

	Sequence		Length	Mass (Da)
	P06311 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: CC8957F0FE3B9012	FASTA	128	14,070
	10 20 30 40 50 60 METPAQLLFL LLLWLPDTTG EIVLTQSPGT LSLSPGESAT LSCRASQSVS SNLAWYQQKR 70 80 90 100 110 120 GQSPRLLIRD ASSRANGIPD RFSGSGSGTD FTLIISRLEP EDFAVYYCQQ YSTSPYTFGQ GTKLEIKR

References

[1]	"Human immunoglobulin kappa light chain genes of subgroups II and III." Klobeck H.G., Meindl A., Combriato G., Solomon A., Zachau H.G. Nucleic Acids Res. 13:6499-6513(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z00021 Genomic DNA. Translation: CAA77316.1.
IPI	IPI00386131.
PIR	K3HU41. A01899.
3D structure databases
ProteinModelPortal	P06311.
ModBase	Search...
Protein family/group databases
MEROPS	I43.001.
IMGT	Search...
Polymorphism databases
DMDM	125815.
Proteomic databases
PeptideAtlas	P06311.
PRIDE	P06311.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P06311.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35537734.

Entry information

Entry name

KV311_HUMAN

Accession

Primary (citable) accession number: P06311

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.