P06310 (KV206_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-II region RPMI 6410
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 133	113	Ig kappa chain V-II region RPMI 6410		PRO_0000015173
Regions
	Region	21 – 43	23	Framework-1
	Region	44 – 59	16	Complementarity-determining-1
	Region	60 – 74	15	Framework-2
	Region	75 – 81	7	Complementarity-determining-2
	Region	82 – 113	32	Framework-3
	Region	114 – 122	9	Complementarity-determining-3
	Region	123 – 132	10	Framework-4
Amino acid modifications
	Disulfide bond	43 ↔ 113		By similarity
Experimental info
	Non-terminal residue	133	1

Sequences

	Sequence		Length	Mass (Da)
	P06310 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 513CCAF3673009EE	FASTA	133	14,707
	10 20 30 40 50 60 MRLPAQLLGL LMLWVPGSSG DVVMTQSPLS LPVTLGQPAS ISCRSSQSLV YSDGNTYLNW 70 80 90 100 110 120 FQQRPGQSPR RLIYKVSNRD SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWS 130 WTFGQGTKVE IKR

References

[1]	"Human immunoglobulin kappa light chain genes of subgroups II and III." Klobeck H.G., Meindl A., Combriato G., Solomon A., Zachau H.G. Nucleic Acids Res. 13:6499-6513(1985) [PubMed: 2997711] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z00020 Genomic DNA. Translation: CAA77315.1.
IPI	IPI00550731.
PIR	K2HURP. A01890.
3D structure databases
ProteinModelPortal	P06310.
SMR	P06310. Positions 21-133.
ModBase	Search...
Protein-protein interaction databases
STRING	P06310.
Protein family/group databases
IMGT	Search...
Polymorphism databases
DMDM	125792.
Proteomic databases
PRIDE	P06310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000468494; ENSP00000418138; ENSG00000243238.
Phylogenomic databases
eggNOG	prNOG20657.
HOGENOM	HBG716786.
HOVERGEN	HBG018013.
InParanoid	P06310.
OrthoDB	EOG4XSKRF.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	P06310.
Genevestigator	P06310.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KV206_HUMAN

Accession

Primary (citable) accession number: P06310

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.