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Protein

Cholecystokinin

Gene

CCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:G66-32178-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP06307.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 10 chains:
Cholecystokinin-58
Short name:
CCK58
Alternative name(s):
(1-49)-CCK58
Cholecystokinin-39
Short name:
CCK39
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-25
Short name:
CCK25
Cholecystokinin-18
Short name:
CCK18
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Cholecystokinin-5
Short name:
CCK5
Gene namesi
Name:CCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1569. CCK.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • axon hillock Source: Ensembl
  • axon initial segment Source: Ensembl
  • dendrite Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: Ensembl
  • perikaryon Source: Ensembl
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi97Y → F: Reduces the quantity of secreted CCK8 by 50%. 1 Publication1

Organism-specific databases

DisGeNETi885.
OpenTargetsiENSG00000187094.
PharmGKBiPA26141.

Chemistry databases

ChEMBLiCHEMBL1649050.

Polymorphism and mutation databases

BioMutaiCCK.
DMDMi115945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001053621 – 115CholecystokininAdd BLAST95
PropeptideiPRO_000001053721 – 44Add BLAST24
PeptideiPRO_000001053846 – 103Cholecystokinin-58Add BLAST58
PeptideiPRO_000030630446 – 94Cholecystokinin-58 desnonopeptideBy similarityAdd BLAST49
PeptideiPRO_000001053965 – 103Cholecystokinin-39Add BLAST39
PeptideiPRO_000001054071 – 103Cholecystokinin-33Add BLAST33
PeptideiPRO_000030630579 – 103Cholecystokinin-25By similarityAdd BLAST25
PeptideiPRO_000030630686 – 103Cholecystokinin-18By similarityAdd BLAST18
PeptideiPRO_000001054192 – 103Cholecystokinin-12Add BLAST12
PeptideiPRO_000001054296 – 103Cholecystokinin-88
PeptideiPRO_000030630797 – 103Cholecystokinin-7By similarity7
PeptideiPRO_000030630899 – 103Cholecystokinin-5By similarity5
PropeptideiPRO_0000010543107 – 1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97Sulfotyrosine1 Publication1
Modified residuei103Phenylalanine amide1 Publication1
Modified residuei111SulfotyrosineBy similarity1
Modified residuei113SulfotyrosineBy similarity1

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP06307.
PeptideAtlasiP06307.
PRIDEiP06307.

PTM databases

iPTMnetiP06307.
PhosphoSitePlusiP06307.

Miscellaneous databases

PMAP-CutDBP06307.

Expressioni

Gene expression databases

BgeeiENSG00000187094.
CleanExiHS_CCK.
ExpressionAtlasiP06307. baseline and differential.
GenevisibleiP06307. HS.

Organism-specific databases

HPAiCAB002308.

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCKBRP322392EBI-6624436,EBI-1753137

GO - Molecular functioni

  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107327. 2 interactors.
IntActiP06307. 2 interactors.
STRINGi9606.ENSP00000335657.

Chemistry databases

BindingDBiP06307.

Structurei

3D structure databases

ProteinModelPortaliP06307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP06307.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
PhylomeDBiP06307.
TreeFamiTF333419.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT
60 70 80 90 100
DGESRAHLGA LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW
110
MDFGRRSAEE YEYPS
Length:115
Mass (Da):12,669
Last modified:January 1, 1988 - v1
Checksum:i8A3EE6442FAEAF4B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01881832G → E.1 PublicationCorresponds to variant rs11571848dbSNPEnsembl.1
Natural variantiVAR_02445295R → W.Corresponds to variant rs3774395dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00354 Genomic DNA. Translation: AAA53094.1.
BT006991 mRNA. Translation: AAP35637.1.
AY514491 Genomic DNA. Translation: AAR89908.1.
BC008283 mRNA. Translation: AAH08283.1.
CCDSiCCDS2696.1.
PIRiA01623. GMHUCP.
RefSeqiNP_000720.1. NM_000729.5.
NP_001167609.1. NM_001174138.2.
UniGeneiHs.458426.

Genome annotation databases

EnsembliENST00000334681; ENSP00000335657; ENSG00000187094.
ENST00000396169; ENSP00000379472; ENSG00000187094.
ENST00000434608; ENSP00000409124; ENSG00000187094.
GeneIDi885.
KEGGihsa:885.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Cholecystokinin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00354 Genomic DNA. Translation: AAA53094.1.
BT006991 mRNA. Translation: AAP35637.1.
AY514491 Genomic DNA. Translation: AAR89908.1.
BC008283 mRNA. Translation: AAH08283.1.
CCDSiCCDS2696.1.
PIRiA01623. GMHUCP.
RefSeqiNP_000720.1. NM_000729.5.
NP_001167609.1. NM_001174138.2.
UniGeneiHs.458426.

3D structure databases

ProteinModelPortaliP06307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107327. 2 interactors.
IntActiP06307. 2 interactors.
STRINGi9606.ENSP00000335657.

Chemistry databases

BindingDBiP06307.
ChEMBLiCHEMBL1649050.

PTM databases

iPTMnetiP06307.
PhosphoSitePlusiP06307.

Polymorphism and mutation databases

BioMutaiCCK.
DMDMi115945.

Proteomic databases

PaxDbiP06307.
PeptideAtlasiP06307.
PRIDEiP06307.

Protocols and materials databases

DNASUi885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334681; ENSP00000335657; ENSG00000187094.
ENST00000396169; ENSP00000379472; ENSG00000187094.
ENST00000434608; ENSP00000409124; ENSG00000187094.
GeneIDi885.
KEGGihsa:885.

Organism-specific databases

CTDi885.
DisGeNETi885.
GeneCardsiCCK.
HGNCiHGNC:1569. CCK.
HPAiCAB002308.
MIMi118440. gene.
neXtProtiNX_P06307.
OpenTargetsiENSG00000187094.
PharmGKBiPA26141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP06307.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
PhylomeDBiP06307.
TreeFamiTF333419.

Enzyme and pathway databases

BioCyciZFISH:G66-32178-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP06307.

Miscellaneous databases

ChiTaRSiCCK. human.
GeneWikiiCholecystokinin.
GenomeRNAii885.
PMAP-CutDBP06307.
PROiP06307.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187094.
CleanExiHS_CCK.
ExpressionAtlasiP06307. baseline and differential.
GenevisibleiP06307. HS.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_HUMAN
AccessioniPrimary (citable) accession number: P06307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.