ID   PAHO_ANSAN              Reviewed;          36 AA.
AC   P06304;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-MAY-2023, entry version 86.
DE   RecName: Full=Pancreatic polypeptide {ECO:0000303|PubMed:6484562};
DE            Short=PP {ECO:0000303|PubMed:6484562};
GN   Name=PPY;
OS   Anser anser anser (Western greylag goose).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8844;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6484562;
RA   Xu Y., Lin N., Zhang Y.S.;
RT   "Isolation and sequence determination of goose pancreatic polypeptide.";
RL   Sci. Sin., Ser. B Chem. Biol. Agric. Med. Earth Sci. 27:590-592(1984).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=6745282; DOI=10.1111/j.1432-1033.1984.tb08298.x;
RA   Glover I.D., Barlow D.J., Pitts J.E., Wood S.P., Tickle I.J.,
RA   Blundell T.L., Tatemoto K., Kimmel J.R., Wollmer A., Strassburger W.,
RA   Zhang Y.S.;
RT   "Conformational studies on the pancreatic polypeptide hormone family.";
RL   Eur. J. Biochem. 142:379-385(1984).
CC   -!- FUNCTION: Hormone secreted by pancreatic cells that acts as a regulator
CC       of pancreatic and gastrointestinal functions.
CC       {ECO:0000250|UniProtKB:P01298}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01298}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A01576; PCGS.
DR   AlphaFoldDB; P06304; -.
DR   SMR; P06304; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.900; -; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Pancreatic polypeptide"
FT                   /id="PRO_0000044803"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   VARIANT         30
FT                   /note="N -> V"
SQ   SEQUENCE   36 AA;  4391 MW;  32141F4536F427EF CRC64;
     GPSQPTYPGN DAPVEDLRFY YDNLQQYRLN VFRHRY
//