P06304 (PAHO_ANSAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pancreatic hormone
Short name=PH

Alternative name(s):
Pancreatic polypeptide
Short name=PP

Gene names

Name:

PPY

Organism

Anser anser anser (Western graylag goose)

Taxonomic identifier

8844 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anser › Anser anser

Protein attributes

Sequence length	36 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 36	36	Pancreatic hormone		PRO_0000044803
Amino acid modifications
	Modified residue	36	1	Tyrosine amide By similarity
Natural variations
	Natural variant	30	1	N → V.

Sequences

	Sequence		Length	Mass (Da)
	P06304 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 32141F4536F427EF	FASTA	36	4,391
	10 20 30 GPSQPTYPGN DAPVEDLRFY YDNLQQYRLN VFRHRY

References

[1]	"Isolation and sequence determination of goose pancreatic polypeptide." Xu Y., Lin N., Zhang Y.S. Sci. Sin., Ser. B Chem. Biol. Agric. Med. Earth Sci. 27:590-592(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Conformational studies on the pancreatic polypeptide hormone family." Glover I.D., Barlow D.J., Pitts J.E., Wood S.P., Tickle I.J., Blundell T.L., Tatemoto K., Kimmel J.R., Wollmer A., Strassburger W., Zhang Y.S. Eur. J. Biochem. 142:379-385(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	PCGS. A01576.
3D structure databases
ProteinModelPortal	P06304.
SMR	P06304. Positions 1-36.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG096194.
Family and domain databases
InterPro	IPR001955. Pancreatic_hormone-like. IPR020392. Pancreatic_hormone-like_CS. [Graphical view]
PANTHER	PTHR10533. PTHR10533. 1 hit.
Pfam	PF00159. Hormone_3. 1 hit. [Graphical view]
PRINTS	PR00278. PANCHORMONE.
ProDom	PD001267. Pancreatic_hormone-like. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00309. PAH. 1 hit. [Graphical view]
PROSITE	PS00265. PANCREATIC_HORMONE_1. 1 hit. PS50276. PANCREATIC_HORMONE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PAHO_ANSAN

Accession

Primary (citable) accession number: P06304

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	April 1, 1988
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program