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P06304 (PAHO_ANSAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pancreatic hormone

Short name=PH
Alternative name(s):
Pancreatic polypeptide
Short name=PP
Gene names
Name:PPY
OrganismAnser anser anser (Western graylag goose)
Taxonomic identifier8844 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Protein attributes

Sequence length36 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

Subcellular location

Secreted.

Sequence similarities

Belongs to the NPY family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHormone
   PTMAmidation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3636Pancreatic hormone
PRO_0000044803

Amino acid modifications

Modified residue361Tyrosine amide By similarity

Natural variations

Natural variant301N → V.

Sequences

Sequence LengthMass (Da)Tools
P06304 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 32141F4536F427EF

FASTA364,391
        10         20         30 
GPSQPTYPGN DAPVEDLRFY YDNLQQYRLN VFRHRY 

« Hide

References

[1]"Isolation and sequence determination of goose pancreatic polypeptide."
Xu Y., Lin N., Zhang Y.S.
Sci. Sin., Ser. B Chem. Biol. Agric. Med. Earth Sci. 27:590-592(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Conformational studies on the pancreatic polypeptide hormone family."
Glover I.D., Barlow D.J., Pitts J.E., Wood S.P., Tickle I.J., Blundell T.L., Tatemoto K., Kimmel J.R., Wollmer A., Strassburger W., Zhang Y.S.
Eur. J. Biochem. 142:379-385(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRPCGS. A01576.

3D structure databases

ProteinModelPortalP06304.
SMRP06304. Positions 1-36.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG096194.

Family and domain databases

InterProIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PfamPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSPR00278. PANCHORMONE.
ProDomPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00309. PAH. 1 hit.
[Graphical view]
PROSITEPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePAHO_ANSAN
AccessionPrimary (citable) accession number: P06304
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 1, 1988
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families