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Protein

Pancreatic hormone

Gene

PPY

Organism
Anser anser anser (Western greylag goose)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic hormone
Short name:
PH
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Gene namesi
Name:PPY
OrganismiAnser anser anser (Western greylag goose)
Taxonomic identifieri8844 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnser

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448031 – 36Pancreatic hormoneAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36Tyrosine amideBy similarity1

Keywords - PTMi

Amidation

Structurei

3D structure databases

ProteinModelPortaliP06304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

HOVERGENiHBG096194.

Family and domain databases

InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P06304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GPSQPTYPGN DAPVEDLRFY YDNLQQYRLN VFRHRY
Length:36
Mass (Da):4,391
Last modified:April 1, 1988 - v1
Checksum:i32141F4536F427EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30N → V. 1

Sequence databases

PIRiA01576. PCGS.

Cross-referencesi

Sequence databases

PIRiA01576. PCGS.

3D structure databases

ProteinModelPortaliP06304.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG096194.

Family and domain databases

InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAHO_ANSAN
AccessioniPrimary (citable) accession number: P06304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 1, 1988
Last modified: October 5, 2016
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.