Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pancreatic prohormone

Gene

Ppy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Cleaved into the following 2 chains:
Gene namesi
Name:Ppy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3385. Ppy.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
PeptideiPRO_000002537230 – 65Pancreatic hormoneAdd BLAST36
PeptideiPRO_000002537369 – 98C-terminal peptideAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amideBy similarity1

Post-translational modificationi

No icosapeptide-like peptide is cleaved from the C-terminal.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06303.
PRIDEiP06303.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020874.
GenevisibleiP06303. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028318.

Structurei

3D structure databases

ProteinModelPortaliP06303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP06303.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG091G15HI.
PhylomeDBiP06303.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAYYCLSL FLLSTWVALL LQPLQGAWGA PLEPMYPGDY ATHEQRAQYE
60 70 80 90
TQLRRYINTL TRPRYGKRDE DTAGLPGRQL PPCTSLLVGL MPCAAARS
Length:98
Mass (Da):10,975
Last modified:January 1, 1988 - v1
Checksum:i56AC03356D248FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13588 mRNA. Translation: AAA41923.1.
M18207 Genomic DNA. Translation: AAA41922.1.
M27450 Genomic DNA. Translation: AAA99236.1.
PIRiA28261. PCRT.
RefSeqiNP_036758.1. NM_012626.2.
UniGeneiRn.9755.

Genome annotation databases

EnsembliENSRNOT00000028318; ENSRNOP00000028318; ENSRNOG00000020874.
GeneIDi24677.
KEGGirno:24677.
UCSCiRGD:3385. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13588 mRNA. Translation: AAA41923.1.
M18207 Genomic DNA. Translation: AAA41922.1.
M27450 Genomic DNA. Translation: AAA99236.1.
PIRiA28261. PCRT.
RefSeqiNP_036758.1. NM_012626.2.
UniGeneiRn.9755.

3D structure databases

ProteinModelPortaliP06303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028318.

Proteomic databases

PaxDbiP06303.
PRIDEiP06303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028318; ENSRNOP00000028318; ENSRNOG00000020874.
GeneIDi24677.
KEGGirno:24677.
UCSCiRGD:3385. rat.

Organism-specific databases

CTDi5539.
RGDi3385. Ppy.

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP06303.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG091G15HI.
PhylomeDBiP06303.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP06303.

Gene expression databases

BgeeiENSRNOG00000020874.
GenevisibleiP06303. RN.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAHO_RAT
AccessioniPrimary (citable) accession number: P06303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 5, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.