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Protein

Pancreatic prohormone

Gene

Ppy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Cleaved into the following 2 chains:
Gene namesi
Name:Ppy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3385. Ppy.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Peptidei30 – 6536Pancreatic hormonePRO_0000025372Add
BLAST
Peptidei69 – 9830C-terminal peptidePRO_0000025373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651Tyrosine amideBy similarity

Post-translational modificationi

No icosapeptide-like peptide is cleaved from the C-terminal.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06303.

Expressioni

Gene expression databases

GenevisibleiP06303. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028318.

Structurei

3D structure databases

ProteinModelPortaliP06303.
SMRiP06303. Positions 30-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP06303.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG7KDFDF.
PhylomeDBiP06303.
TreeFamiTF332778.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAYYCLSL FLLSTWVALL LQPLQGAWGA PLEPMYPGDY ATHEQRAQYE
60 70 80 90
TQLRRYINTL TRPRYGKRDE DTAGLPGRQL PPCTSLLVGL MPCAAARS
Length:98
Mass (Da):10,975
Last modified:January 1, 1988 - v1
Checksum:i56AC03356D248FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13588 mRNA. Translation: AAA41923.1.
M18207 Genomic DNA. Translation: AAA41922.1.
M27450 Genomic DNA. Translation: AAA99236.1.
PIRiA28261. PCRT.
RefSeqiNP_036758.1. NM_012626.2.
UniGeneiRn.9755.

Genome annotation databases

EnsembliENSRNOT00000028318; ENSRNOP00000028318; ENSRNOG00000020874.
GeneIDi24677.
KEGGirno:24677.
UCSCiRGD:3385. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13588 mRNA. Translation: AAA41923.1.
M18207 Genomic DNA. Translation: AAA41922.1.
M27450 Genomic DNA. Translation: AAA99236.1.
PIRiA28261. PCRT.
RefSeqiNP_036758.1. NM_012626.2.
UniGeneiRn.9755.

3D structure databases

ProteinModelPortaliP06303.
SMRiP06303. Positions 30-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028318.

Proteomic databases

PaxDbiP06303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028318; ENSRNOP00000028318; ENSRNOG00000020874.
GeneIDi24677.
KEGGirno:24677.
UCSCiRGD:3385. rat.

Organism-specific databases

CTDi5539.
RGDi3385. Ppy.

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP06303.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG7KDFDF.
PhylomeDBiP06303.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP06303.

Gene expression databases

GenevisibleiP06303. RN.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mosaic evolution of prepropancreatic polypeptide."
    Yamamoto H., Nata K., Okamoto H.
    J. Biol. Chem. 261:6156-6159(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene."
    Yonekura H., Nata K., Watanabe T., Kurashina Y., Yamamoto H., Okamoto H.
    J. Biol. Chem. 263:2990-2997(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Different splice site utilization generates diversity between the rat and human pancreatic polypeptide precursors."
    Kopin A.S., Toder A.E., Leiter A.B.
    Arch. Biochem. Biophys. 267:742-748(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPAHO_RAT
AccessioniPrimary (citable) accession number: P06303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.