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Protein

Prothymosin alpha

Gene

Ptma

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Biological processi

  • cell differentiation Source: RGD
  • cell proliferation Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • positive regulation of NF-kappaB transcription factor activity Source: CAFA
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:Ptma
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 13, Chromosome 9

Organism-specific databases

RGDi61829. Ptma.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232581 – 112Prothymosin alphaAdd BLAST112
Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00002992532 – 112Prothymosin alpha, N-terminally processedAdd BLAST111
PeptideiPRO_00000298672 – 29Thymosin alphaAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processed1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateBy similarity1
Modified residuei15N6-succinyllysine; alternateBy similarity1
Modified residuei102PhosphothreonineBy similarity1
Modified residuei103N6-acetyllysine; alternateBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei108PhosphothreonineBy similarity1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP06302.
PRIDEiP06302.

PTM databases

iPTMnetiP06302.
PhosphoSitePlusiP06302.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018584.
GenevisibleiP06302. RN.

Interactioni

Protein-protein interaction databases

BioGridi1198718. 1 interactor.
247900. 1 interactor.
STRINGi10116.ENSRNOP00000059708.

Structurei

3D structure databases

SMRiP06302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06302.
KOiK13784.
OMAiANWNDNE.
TreeFamiTF350357.

Family and domain databases

InterProiView protein in InterPro
IPR004931. Pro/parathymosin.
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiView protein in Pfam
PF03247. Prothymosin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
ETKKQKKTDE DD
Length:112
Mass (Da):12,382
Last modified:January 23, 2007 - v2
Checksum:iFD145E1C06F133E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20035 mRNA. Translation: AAA42241.1.
M86564 mRNA. Translation: AAA40758.1.
M33024 mRNA. Translation: AAA41931.1.
X55326 mRNA. Translation: CAA39028.1.
BC061972 mRNA. Translation: AAH61972.1.
BC092569 mRNA. Translation: AAH92569.1.
PIRiA32265. TNRTA.
RefSeqiNP_068508.1. NM_021740.1.
XP_003751326.1. XM_003751278.4.
XP_003752724.1. XM_003752676.4.
UniGeneiRn.817.

Genome annotation databases

EnsembliENSRNOT00000025093; ENSRNOP00000025093; ENSRNOG00000018584.
ENSRNOT00000051368; ENSRNOP00000059708; ENSRNOG00000025731.
GeneIDi100359583.
29222.
KEGGirno:100359583.
rno:29222.
UCSCiRGD:61829. rat.

Similar proteinsi

Entry informationi

Entry nameiPTMA_RAT
AccessioniPrimary (citable) accession number: P06302
Secondary accession number(s): Q569C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families