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Protein

Prothymosin alpha

Gene

Ptma

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Biological processi

  • cell differentiation Source: RGD
  • cell proliferation Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:Ptma
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 13, Chromosome 9

Organism-specific databases

RGDi61829. Ptma.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232581 – 112Prothymosin alphaAdd BLAST112
Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00002992532 – 112Prothymosin alpha, N-terminally processedAdd BLAST111
PeptideiPRO_00000298672 – 29Thymosin alphaAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processed1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateBy similarity1
Modified residuei15N6-succinyllysine; alternateBy similarity1
Modified residuei102PhosphothreonineBy similarity1
Modified residuei103N6-acetyllysineBy similarity1
Modified residuei108PhosphothreonineBy similarity1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP06302.
PRIDEiP06302.

PTM databases

iPTMnetiP06302.
PhosphoSitePlusiP06302.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018584.
GenevisibleiP06302. RN.

Interactioni

Protein-protein interaction databases

BioGridi1198718. 1 interactor.
247900. 1 interactor.
STRINGi10116.ENSRNOP00000059708.

Structurei

3D structure databases

DisProtiDP00058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06302.
KOiK13784.
OMAiANWNDNE.
TreeFamiTF350357.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
ETKKQKKTDE DD
Length:112
Mass (Da):12,382
Last modified:January 23, 2007 - v2
Checksum:iFD145E1C06F133E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20035 mRNA. Translation: AAA42241.1.
M86564 mRNA. Translation: AAA40758.1.
M33024 mRNA. Translation: AAA41931.1.
X55326 mRNA. Translation: CAA39028.1.
BC061972 mRNA. Translation: AAH61972.1.
BC092569 mRNA. Translation: AAH92569.1.
PIRiA32265. TNRTA.
RefSeqiNP_068508.1. NM_021740.1.
XP_003751326.1. XM_003751278.4.
XP_003752724.1. XM_003752676.4.
UniGeneiRn.817.

Genome annotation databases

EnsembliENSRNOT00000025093; ENSRNOP00000025093; ENSRNOG00000018584.
ENSRNOT00000051368; ENSRNOP00000059708; ENSRNOG00000025731.
GeneIDi100359583.
29222.
KEGGirno:100359583.
rno:29222.
UCSCiRGD:61829. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20035 mRNA. Translation: AAA42241.1.
M86564 mRNA. Translation: AAA40758.1.
M33024 mRNA. Translation: AAA41931.1.
X55326 mRNA. Translation: CAA39028.1.
BC061972 mRNA. Translation: AAH61972.1.
BC092569 mRNA. Translation: AAH92569.1.
PIRiA32265. TNRTA.
RefSeqiNP_068508.1. NM_021740.1.
XP_003751326.1. XM_003751278.4.
XP_003752724.1. XM_003752676.4.
UniGeneiRn.817.

3D structure databases

DisProtiDP00058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1198718. 1 interactor.
247900. 1 interactor.
STRINGi10116.ENSRNOP00000059708.

PTM databases

iPTMnetiP06302.
PhosphoSitePlusiP06302.

Proteomic databases

PaxDbiP06302.
PRIDEiP06302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025093; ENSRNOP00000025093; ENSRNOG00000018584.
ENSRNOT00000051368; ENSRNOP00000059708; ENSRNOG00000025731.
GeneIDi100359583.
29222.
KEGGirno:100359583.
rno:29222.
UCSCiRGD:61829. rat.

Organism-specific databases

CTDi5757.
RGDi61829. Ptma.

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06302.
KOiK13784.
OMAiANWNDNE.
TreeFamiTF350357.

Miscellaneous databases

PROiP06302.

Gene expression databases

BgeeiENSRNOG00000018584.
GenevisibleiP06302. RN.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_RAT
AccessioniPrimary (citable) accession number: P06302
Secondary accession number(s): Q569C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.