Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prothymosin alpha

Gene

Ptma

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Biological processi

  • cell differentiation Source: RGD
  • cell proliferation Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:Ptma
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 13, Chromosome 9

Organism-specific databases

RGDi61829. Ptma.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112Prothymosin alphaPRO_0000423258Add
BLAST
Initiator methionineiRemoved; alternate1 Publication
Chaini2 – 112111Prothymosin alpha, N-terminally processedPRO_0000299253Add
BLAST
Peptidei2 – 2928Thymosin alphaPRO_0000029867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylserine; in Prothymosin alpha, N-terminally processed1 Publication
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei13 – 131PhosphothreonineBy similarity
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151N6-acetyllysine; alternateBy similarity
Modified residuei15 – 151N6-succinyllysine; alternateBy similarity
Modified residuei102 – 1021PhosphothreonineBy similarity
Modified residuei103 – 1031N6-acetyllysineBy similarity
Modified residuei108 – 1081PhosphothreonineBy similarity

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP06302.
PRIDEiP06302.

PTM databases

iPTMnetiP06302.

Expressioni

Gene expression databases

GenevisibleiP06302. RN.

Interactioni

Protein-protein interaction databases

BioGridi1198718. 1 interaction.
247900. 1 interaction.
STRINGi10116.ENSRNOP00000059708.

Structurei

3D structure databases

DisProtiDP00058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 10160Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06302.
KOiK13784.
OMAiANWNDNE.
OrthoDBiEOG70PC27.
TreeFamiTF350357.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
ETKKQKKTDE DD
Length:112
Mass (Da):12,382
Last modified:January 23, 2007 - v2
Checksum:iFD145E1C06F133E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20035 mRNA. Translation: AAA42241.1.
M86564 mRNA. Translation: AAA40758.1.
M33024 mRNA. Translation: AAA41931.1.
X55326 mRNA. Translation: CAA39028.1.
BC061972 mRNA. Translation: AAH61972.1.
BC092569 mRNA. Translation: AAH92569.1.
PIRiA32265. TNRTA.
RefSeqiNP_068508.1. NM_021740.1.
XP_003751326.1. XM_003751278.3.
XP_003752724.1. XM_003752676.3.
UniGeneiRn.817.

Genome annotation databases

EnsembliENSRNOT00000025093; ENSRNOP00000025093; ENSRNOG00000018584.
ENSRNOT00000051368; ENSRNOP00000059708; ENSRNOG00000025731.
GeneIDi100359583.
29222.
KEGGirno:100359583.
rno:29222.
UCSCiRGD:61829. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20035 mRNA. Translation: AAA42241.1.
M86564 mRNA. Translation: AAA40758.1.
M33024 mRNA. Translation: AAA41931.1.
X55326 mRNA. Translation: CAA39028.1.
BC061972 mRNA. Translation: AAH61972.1.
BC092569 mRNA. Translation: AAH92569.1.
PIRiA32265. TNRTA.
RefSeqiNP_068508.1. NM_021740.1.
XP_003751326.1. XM_003751278.3.
XP_003752724.1. XM_003752676.3.
UniGeneiRn.817.

3D structure databases

DisProtiDP00058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1198718. 1 interaction.
247900. 1 interaction.
STRINGi10116.ENSRNOP00000059708.

PTM databases

iPTMnetiP06302.

Proteomic databases

PaxDbiP06302.
PRIDEiP06302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025093; ENSRNOP00000025093; ENSRNOG00000018584.
ENSRNOT00000051368; ENSRNOP00000059708; ENSRNOG00000025731.
GeneIDi100359583.
29222.
KEGGirno:100359583.
rno:29222.
UCSCiRGD:61829. rat.

Organism-specific databases

CTDi5757.
RGDi61829. Ptma.

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06302.
KOiK13784.
OMAiANWNDNE.
OrthoDBiEOG70PC27.
TreeFamiTF350357.

Miscellaneous databases

NextBioi608423.
PROiP06302.

Gene expression databases

GenevisibleiP06302. RN.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-112, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2.
  2. "Prothymosin alpha and parathymosin: amino acid sequences deduced from the cloned rat spleen cDNAs."
    Frangou-Lazaridis M., Clinton M., Goodall G.J., Horecker B.L.
    Arch. Biochem. Biophys. 263:305-310(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  3. "The MYC protein activates transcription of the alpha-prothymosin gene."
    Eilers M., Schirm S., Bishop J.M.
    EMBO J. 10:133-141(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Prostate.
  5. "Identification of a low-Mr acidic nuclear protein as prothymosin alpha."
    Palvimo J., Linnala-Kankkunen A.
    FEBS Lett. 277:257-260(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTMA_RAT
AccessioniPrimary (citable) accession number: P06302
Secondary accession number(s): Q569C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.