Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proenkephalin-B

Gene

Pdyn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:Pdyn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62054. Pdyn.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: GO_Central
  • cytoplasm Source: RGD
  • dendrite Source: GO_Central
  • extracellular region Source: GO_Central
  • neuronal cell body Source: RGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000819822 – 163Add BLAST142
PeptideiPRO_0000306365166 – 175Alpha-neoendorphin10
PeptideiPRO_0000008199166 – 174Beta-neoendorphin9
PeptideiPRO_0000008200166 – 170Leu-enkephalin5
PropeptideiPRO_0000008201177 – 199Add BLAST23
PeptideiPRO_0000306366202 – 233Big dynorphinBy similarityAdd BLAST32
PeptideiPRO_0000008202202 – 218Dynorphin A(1-17)Add BLAST17
PeptideiPRO_0000306367202 – 214Dynorphin A(1-13)By similarityAdd BLAST13
PeptideiPRO_0000306368202 – 209Dynorphin A(1-8)By similarity8
PeptideiPRO_0000008203202 – 206Leu-enkephalin5
PeptideiPRO_0000008204221 – 248LeumorphinAdd BLAST28
PeptideiPRO_0000306369221 – 233RimorphinBy similarityAdd BLAST13
PeptideiPRO_0000008205221 – 225Leu-enkephalin5

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP06300.
PRIDEiP06300.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038921.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP06300.
PhylomeDBiP06300.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSRLMLAA CLLVIPSEVA ADCLSLCSLC AVRTQDGPHP INPLICSLEC
60 70 80 90 100
QDLVPPSEEW ETCRGFWSFL TLTASGLHGK DDLENEVALE EGYTALTKLL
110 120 130 140 150
EPLLKELEKG QLLTSVSEEK LRGLSSRFGN GRESELLGTD LMNDEAAQAG
160 170 180 190 200
TLHFNEEDLR KQAKRYGGFL RKYPKRSSEM TGDEDRGQDG DQVGHEDLYK
210 220 230 240
RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN TYSEDLDV
Length:248
Mass (Da):28,079
Last modified:November 1, 1997 - v2
Checksum:i899F1B24CA3D1E91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181T → A in AAA41118 (PubMed:3858883).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32784, M32783 Genomic DNA. Translation: AAA41117.1.
M10088 Genomic DNA. Translation: AAA41118.1.
PIRiA41395. DFRTP.
UniGeneiRn.44471.

Genome annotation databases

UCSCiRGD:62054. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32784, M32783 Genomic DNA. Translation: AAA41117.1.
M10088 Genomic DNA. Translation: AAA41118.1.
PIRiA41395. DFRTP.
UniGeneiRn.44471.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038921.

Proteomic databases

PaxDbiP06300.
PRIDEiP06300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:62054. rat.

Organism-specific databases

RGDi62054. Pdyn.

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP06300.
PhylomeDBiP06300.

Miscellaneous databases

PROiP06300.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDYN_RAT
AccessioniPrimary (citable) accession number: P06300
Secondary accession number(s): Q63193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.