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Protein

Corticoliberin

Gene

CRH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland (PubMed:3878520). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:CRH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 1481241 PublicationPRO_0000006216Add
BLAST
Peptidei149 – 18941CorticoliberinPRO_0000006217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891Isoleucine amide

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06296.

Expressioni

Tissue specificityi

Produced by the hypothalamus.1 Publication

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006626.

Structurei

3D structure databases

ProteinModelPortaliP06296.
SMRiP06296. Positions 149-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP06296.
KOiK05256.
OMAiSALGGHQ.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VLGARQAPQH PQALDFLQPQ
60 70 80 90 100
QQPQQPQPRP VLLRMGEEYF LRLGNLNKSP AAPLSPASSP LTGSSGNRPD
110 120 130 140 150
EVAANFFRAL LQQLPLPRRP LDSPSGPAER GAENALSSRQ EAPERERRSE
160 170 180 190
EPPISLDLTF HLLREVLEMA RAEQLAQQAH SNRKLMEIIG K
Length:191
Mass (Da):20,997
Last modified:February 26, 2008 - v3
Checksum:i587E58F516AB9006
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71V → A in AAN40888 (PubMed:12030933).Curated
Sequence conflicti39 – 402QH → HS in CAA75424 (PubMed:9734873).Curated
Sequence conflicti79 – 791S → N in CAA75424 (PubMed:9734873).Curated
Sequence conflicti120 – 1201P → R in CAA75424 (PubMed:9734873).Curated
Sequence conflicti188 – 1881I → F AA sequence (PubMed:3878520).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15159 Genomic DNA. Translation: CAA75424.1.
AF440229 Genomic DNA. Translation: AAN40888.1.
DQ358705 Genomic DNA. Translation: ABD34973.1.
PIRiA01404. RHPGCE.
RefSeqiNP_001106533.1. NM_001113062.1.
XP_013852166.1. XM_013996712.1.
UniGeneiSsc.69887.

Genome annotation databases

EnsembliENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
GeneIDi100127468.
KEGGissc:100127468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15159 Genomic DNA. Translation: CAA75424.1.
AF440229 Genomic DNA. Translation: AAN40888.1.
DQ358705 Genomic DNA. Translation: ABD34973.1.
PIRiA01404. RHPGCE.
RefSeqiNP_001106533.1. NM_001113062.1.
XP_013852166.1. XM_013996712.1.
UniGeneiSsc.69887.

3D structure databases

ProteinModelPortaliP06296.
SMRiP06296. Positions 149-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006626.

Proteomic databases

PaxDbiP06296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
GeneIDi100127468.
KEGGissc:100127468.

Organism-specific databases

CTDi1392.

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP06296.
KOiK05256.
OMAiSALGGHQ.
TreeFamiTF332956.

Enzyme and pathway databases

ReactomeiR-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the porcine corticotropin-releasing factor gene."
    Mimmack M.L., Parrott R.F., Vellucci S.V.
    J. Anim. Sci. 76:2205-2206(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence variation and linkage mapping of the porcine corticotropin releasing hormone (CRH) gene."
    Wimmers K., Murani E., Ponsuksili S., Schellander K.
    Anim. Genet. 33:233-234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular characterization and evidencing of the porcine CRH gene as a functional-positional candidate for growth and body composition."
    Murani E., Muraniova M., Ponsuksili S., Schellander K., Wimmers K.
    Biochem. Biophys. Res. Commun. 342:394-405(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Isolation and amino acid sequence of corticotropin-releasing factor from pig hypothalami."
    Patthy M., Horvath J., Mason-Garcia M., Szoke B., Schlesinger D.H., Schally A.V.
    Proc. Natl. Acad. Sci. U.S.A. 82:8762-8766(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 149-189, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRF_PIG
AccessioniPrimary (citable) accession number: P06296
Secondary accession number(s): O62637, Q0ZLZ2, Q8HZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 26, 2008
Last modified: January 20, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.