CRH

Functionⁱ

Hormone regulating the release of corticotropin from pituitary gland (PubMed:3878520). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

corticotropin-releasing hormone activity Source: GO_Central
neuropeptide hormone activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

adrenal gland development Source: Ensembl
female pregnancy Source: Ensembl
glucocorticoid biosynthetic process Source: Ensembl
inflammatory response Source: Ensembl
locomotory exploration behavior Source: Ensembl
lung development Source: Ensembl
negative regulation of epinephrine secretion Source: GO_Central
negative regulation of glucagon secretion Source: GO_Central
positive regulation of cortisol secretion Source: GO_Central
regulation of NMDA receptor activity Source: Ensembl
signal transduction Source: GO_Central
synaptic transmission, dopaminergic Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-SSC-373080. Class B/2 (Secretin family receptors). R-SSC-418555. G alpha (s) signalling events.

Reactomeⁱ

R-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Corticoliberin Alternative name(s): Corticotropin-releasing factor Short name: CRF Corticotropin-releasing hormone
Gene namesⁱ	Name:CRH
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Chromosome 4

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "Isolation and amino acid sequence of corticotropin-releasing factor from pig hypothalami."
  Patthy M., Horvath J., Mason-Garcia M., Szoke B., Schlesinger D.H., Schally A.V.
  Proc. Natl. Acad. Sci. U.S.A. 82:8762-8766(1985) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 149-189, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Cellular componentⁱ

extracellular space Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST	24
PropeptideⁱPRO_0000006216	25 – 148	1 PublicationAdd BLAST	124
PeptideⁱPRO_0000006217	149 – 189	CorticoliberinAdd BLAST	41

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	189	Isoleucine amideBy similarity		1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	P06296.
PRIDEⁱ	P06296.

Expressionⁱ

Tissue specificityⁱ

Produced by the hypothalamus.1 Publication

Gene expression databases

ExpressionAtlasⁱ	P06296. differential.

ExpressionAtlasⁱ

P06296. differential.

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

GO - Molecular functionⁱ

corticotropin-releasing hormone activity Source: GO_Central
neuropeptide hormone activity Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000006626.

STRINGⁱ

9823.ENSSSCP00000006626.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P06296.
SMRⁱ	P06296.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWZK. Eukaryota. ENOG4111ZIN. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048573.
HOGENOMⁱ	HOG000004762.
HOVERGENⁱ	HBG001951.
InParanoidⁱ	P06296.
KEGG Orthology (KO) More...KOⁱ	K05256.
OMAⁱ	YFIRLGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QDI.
TreeFamⁱ	TF332956.

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446. Corticotropin-releasing_fac_CS. IPR000187. CRF. IPR003620. Urocortin_CRF.
PANTHERⁱ	PTHR15035. PTHR15035. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00473. CRF. 1 hit.
PRINTSⁱ	PR01612. CRFFAMILY.
SMARTⁱ	View protein in SMART SM00039. CRF. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00511. CRF. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06296-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VLGARQAPQH PQALDFLQPQ 
        60         70         80         90        100
QQPQQPQPRP VLLRMGEEYF LRLGNLNKSP AAPLSPASSP LTGSSGNRPD 
       110        120        130        140        150
EVAANFFRAL LQQLPLPRRP LDSPSGPAER GAENALSSRQ EAPERERRSE 
       160        170        180        190 
EPPISLDLTF HLLREVLEMA RAEQLAQQAH SNRKLMEIIG K

Length:191

Mass (Da):20,997

Last modified:February 26, 2008 - v3

Checksum:ⁱ587E58F516AB9006

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	V → A in AAN40888 (PubMed:12030933).Curated	1
Sequence conflictⁱ	39 – 40	QH → HS in CAA75424 (PubMed:9734873).Curated	2
Sequence conflictⁱ	79	S → N in CAA75424 (PubMed:9734873).Curated	1
Sequence conflictⁱ	120	P → R in CAA75424 (PubMed:9734873).Curated	1
Sequence conflictⁱ	188	I → F AA sequence (PubMed:3878520).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y15159 Genomic DNA. Translation: CAA75424.1. AF440229 Genomic DNA. Translation: AAN40888.1. DQ358705 Genomic DNA. Translation: ABD34973.1.
PIRⁱ	A01404. RHPGCE.
NCBI Reference Sequences More...RefSeqⁱ	NP_001106533.1. NM_001113062.1. XP_013852166.1. XM_013996712.1.
UniGeneⁱ	Ssc.69887.

Genome annotation databases

Ensemblⁱ	ENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
GeneIDⁱ	100127468.
KEGGⁱ	ssc:100127468.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y15159 Genomic DNA. Translation: CAA75424.1. AF440229 Genomic DNA. Translation: AAN40888.1. DQ358705 Genomic DNA. Translation: ABD34973.1.
PIRⁱ	A01404. RHPGCE.
NCBI Reference Sequences More...RefSeqⁱ	NP_001106533.1. NM_001113062.1. XP_013852166.1. XM_013996712.1.
UniGeneⁱ	Ssc.69887.

3D structure databases

ProteinModelPortalⁱ	P06296.
SMRⁱ	P06296.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000006626.

STRINGⁱ

9823.ENSSSCP00000006626.

Proteomic databases

PaxDbⁱ	P06296.
PRIDEⁱ	P06296.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
GeneIDⁱ	100127468.
KEGGⁱ	ssc:100127468.

Organism-specific databases

CTDⁱ	1392.

CTDⁱ

1392.

Phylogenomic databases

eggNOGⁱ	ENOG410IWZK. Eukaryota. ENOG4111ZIN. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048573.
HOGENOMⁱ	HOG000004762.
HOVERGENⁱ	HBG001951.
InParanoidⁱ	P06296.
KEGG Orthology (KO) More...KOⁱ	K05256.
OMAⁱ	YFIRLGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QDI.
TreeFamⁱ	TF332956.

Enzyme and pathway databases

Reactomeⁱ	R-SSC-373080. Class B/2 (Secretin family receptors). R-SSC-418555. G alpha (s) signalling events.

Reactomeⁱ

R-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Gene expression databases

ExpressionAtlasⁱ	P06296. differential.

ExpressionAtlasⁱ

P06296. differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446. Corticotropin-releasing_fac_CS. IPR000187. CRF. IPR003620. Urocortin_CRF.
PANTHERⁱ	PTHR15035. PTHR15035. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00473. CRF. 1 hit.
PRINTSⁱ	PR01612. CRFFAMILY.
SMARTⁱ	View protein in SMART SM00039. CRF. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00511. CRF. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CRF_PIG
Accessionⁱ	P06296Primary (citable) accession number: P06296 Secondary accession number(s): O62637, Q0ZLZ2, Q8HZV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	February 26, 2008
	Last modified:	July 5, 2017
	This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06296 (CRF_PIG)

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Corticoliberin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ