UniProtKB - P06296 (CRF_PIG)
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Protein
Corticoliberin
Gene
CRH
Organism
Sus scrofa (Pig)
Status
Functioni
Hormone regulating the release of corticotropin from pituitary gland (PubMed:3878520). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity1 Publication
GO - Molecular functioni
- corticotropin-releasing hormone activity Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
GO - Biological processi
- adrenal gland development Source: Ensembl
- female pregnancy Source: Ensembl
- glucocorticoid biosynthetic process Source: Ensembl
- inflammatory response Source: Ensembl
- locomotory exploration behavior Source: Ensembl
- lung development Source: Ensembl
- negative regulation of epinephrine secretion Source: GO_Central
- negative regulation of glucagon secretion Source: GO_Central
- positive regulation of corticotropin secretion Source: Ensembl
- positive regulation of cortisol secretion Source: GO_Central
- regulation of NMDA receptor activity Source: Ensembl
- signal transduction Source: GO_Central
- synaptic transmission, dopaminergic Source: Ensembl
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-SSC-373080. Class B/2 (Secretin family receptors). R-SSC-418555. G alpha (s) signalling events. |
Names & Taxonomyi
Protein namesi | Recommended name: CorticoliberinAlternative name(s): Corticotropin-releasing factor Short name: CRF Corticotropin-releasing hormone |
Gene namesi | Name:CRH |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000006216 | 25 – 148 | 1 PublicationAdd BLAST | 124 | |
PeptideiPRO_0000006217 | 149 – 189 | CorticoliberinAdd BLAST | 41 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 189 | Isoleucine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
PaxDbi | P06296. |
PRIDEi | P06296. |
Expressioni
Tissue specificityi
Produced by the hypothalamus.1 Publication
Gene expression databases
Bgeei | ENSSSCG00000006215. |
Interactioni
Subunit structurei
Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity
GO - Molecular functioni
- corticotropin-releasing hormone activity Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000006626. |
Structurei
3D structure databases
ProteinModelPortali | P06296. |
SMRi | P06296. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IWZK. Eukaryota. ENOG4111ZIN. LUCA. |
GeneTreei | ENSGT00510000048573. |
HOGENOMi | HOG000004762. |
HOVERGENi | HBG001951. |
InParanoidi | P06296. |
KOi | K05256. |
OMAi | REMMEMS. |
OrthoDBi | EOG091G0QDI. |
TreeFami | TF332956. |
Family and domain databases
InterProi | View protein in InterPro IPR018446. Corticotropin-releasing_fac_CS. IPR000187. CRF. IPR003620. Urocortin_CRF. |
PANTHERi | PTHR15035. PTHR15035. 1 hit. |
Pfami | View protein in Pfam PF00473. CRF. 1 hit. |
PRINTSi | PR01612. CRFFAMILY. |
SMARTi | View protein in SMART SM00039. CRF. 1 hit. |
PROSITEi | View protein in PROSITE PS00511. CRF. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06296-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VLGARQAPQH PQALDFLQPQ
60 70 80 90 100
QQPQQPQPRP VLLRMGEEYF LRLGNLNKSP AAPLSPASSP LTGSSGNRPD
110 120 130 140 150
EVAANFFRAL LQQLPLPRRP LDSPSGPAER GAENALSSRQ EAPERERRSE
160 170 180 190
EPPISLDLTF HLLREVLEMA RAEQLAQQAH SNRKLMEIIG K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | V → A in AAN40888 (PubMed:12030933).Curated | 1 | |
Sequence conflicti | 39 – 40 | QH → HS in CAA75424 (PubMed:9734873).Curated | 2 | |
Sequence conflicti | 79 | S → N in CAA75424 (PubMed:9734873).Curated | 1 | |
Sequence conflicti | 120 | P → R in CAA75424 (PubMed:9734873).Curated | 1 | |
Sequence conflicti | 188 | I → F AA sequence (PubMed:3878520).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y15159 Genomic DNA. Translation: CAA75424.1. AF440229 Genomic DNA. Translation: AAN40888.1. DQ358705 Genomic DNA. Translation: ABD34973.1. |
PIRi | A01404. RHPGCE. |
RefSeqi | NP_001106533.1. NM_001113062.1. XP_013852166.1. XM_013996712.1. |
UniGenei | Ssc.69887. |
Genome annotation databases
Ensembli | ENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215. |
GeneIDi | 100127468. |
KEGGi | ssc:100127468. |
Similar proteinsi
Entry informationi
Entry namei | CRF_PIG | |
Accessioni | P06296Primary (citable) accession number: P06296 Secondary accession number(s): O62637, Q0ZLZ2, Q8HZV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 26, 2008 | |
Last modified: | March 28, 2018 | |
This is version 110 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |