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Protein

CDP-diacylglycerol pyrophosphatase

Gene

cdh

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CDP-diacylglycerol + H2O = CMP + phosphatidate.

Pathwayi: CDP-diacylglycerol degradation

This protein is involved in step 1 of the subpathway that synthesizes phosphatidate from CDP-diacylglycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. CDP-diacylglycerol pyrophosphatase (cdh)
This subpathway is part of the pathway CDP-diacylglycerol degradation, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidate from CDP-diacylglycerol, the pathway CDP-diacylglycerol degradation and in Phospholipid metabolism.

GO - Molecular functioni

  • CDP-diacylglycerol diphosphatase activity Source: EcoCyc

GO - Biological processi

  • CDP-diacylglycerol catabolic process Source: EcoCyc
  • phospholipid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:CDPDIGLYPYPHOSPHA-MONOMER.
ECOL316407:JW3889-MONOMER.
MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER.
UniPathwayiUPA00609; UER00664.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol pyrophosphatase (EC:3.6.1.26)
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene namesi
Name:cdh
Ordered Locus Names:b3918, JW3889
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10138. cdh.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001985731 – 251CDP-diacylglycerol pyrophosphataseAdd BLAST251

Proteomic databases

PaxDbiP06282.
PRIDEiP06282.

Interactioni

Protein-protein interaction databases

BioGridi4261218. 158 interactors.
IntActiP06282. 3 interactors.
STRINGi511145.b3918.

Structurei

3D structure databases

ProteinModelPortaliP06282.
SMRiP06282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdh family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EAF. Bacteria.
COG2134. LUCA.
HOGENOMiHOG000048713.
InParanoidiP06282.
KOiK01521.
OMAiSPFIMLA.
PhylomeDBiP06282.

Family and domain databases

HAMAPiMF_00319. Cdh. 1 hit.
InterProiIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
IPR011146. HIT-like.
[Graphical view]
PfamiPF02611. CDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001273. CDH. 1 hit.
SUPFAMiSSF54197. SSF54197. 1 hit.
TIGRFAMsiTIGR00672. cdh. 1 hit.

Sequencei

Sequence statusi: Complete.

P06282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ
60 70 80 90 100
NPSPCAEVKP NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF
110 120 130 140 150
FWLAWQARDF MSKKYGQPVP DRAVSLAINS RTGRTQNHFH IHISCIRPDV
160 170 180 190 200
RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR RVTESELVQR SPFMMLAEEV
210 220 230 240 250
PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE EIQDHQCEIL

R
Length:251
Mass (Da):28,451
Last modified:January 1, 1988 - v1
Checksum:iF2E704FD5E164779
GO

Sequence cautioni

The sequence CAA26358 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11331 Genomic DNA. Translation: AAA23543.1.
X02519 Genomic DNA. Translation: CAA26358.1. Frameshift.
L19201 Genomic DNA. Translation: AAB03050.1.
U00096 Genomic DNA. Translation: AAC76900.1.
AP009048 Genomic DNA. Translation: BAE77392.1.
PIRiA01019. PSECCD.
RefSeqiNP_418353.1. NC_000913.3.
WP_001326656.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76900; AAC76900; b3918.
BAE77392; BAE77392; BAE77392.
GeneIDi948410.
KEGGiecj:JW3889.
eco:b3918.
PATRICi32123349. VBIEscCol129921_4035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11331 Genomic DNA. Translation: AAA23543.1.
X02519 Genomic DNA. Translation: CAA26358.1. Frameshift.
L19201 Genomic DNA. Translation: AAB03050.1.
U00096 Genomic DNA. Translation: AAC76900.1.
AP009048 Genomic DNA. Translation: BAE77392.1.
PIRiA01019. PSECCD.
RefSeqiNP_418353.1. NC_000913.3.
WP_001326656.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP06282.
SMRiP06282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261218. 158 interactors.
IntActiP06282. 3 interactors.
STRINGi511145.b3918.

Proteomic databases

PaxDbiP06282.
PRIDEiP06282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76900; AAC76900; b3918.
BAE77392; BAE77392; BAE77392.
GeneIDi948410.
KEGGiecj:JW3889.
eco:b3918.
PATRICi32123349. VBIEscCol129921_4035.

Organism-specific databases

EchoBASEiEB0136.
EcoGeneiEG10138. cdh.

Phylogenomic databases

eggNOGiENOG4105EAF. Bacteria.
COG2134. LUCA.
HOGENOMiHOG000048713.
InParanoidiP06282.
KOiK01521.
OMAiSPFIMLA.
PhylomeDBiP06282.

Enzyme and pathway databases

UniPathwayiUPA00609; UER00664.
BioCyciEcoCyc:CDPDIGLYPYPHOSPHA-MONOMER.
ECOL316407:JW3889-MONOMER.
MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER.

Miscellaneous databases

PROiP06282.

Family and domain databases

HAMAPiMF_00319. Cdh. 1 hit.
InterProiIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
IPR011146. HIT-like.
[Graphical view]
PfamiPF02611. CDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001273. CDH. 1 hit.
SUPFAMiSSF54197. SSF54197. 1 hit.
TIGRFAMsiTIGR00672. cdh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDH_ECOLI
AccessioniPrimary (citable) accession number: P06282
Secondary accession number(s): Q2M8L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.