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P06282 (CDH_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDP-diacylglycerol pyrophosphatase

EC=3.6.1.26
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene names
Name:cdh
Ordered Locus Names:b3918, JW3889
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319

Pathway

Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319

Subcellular location

Cell inner membrane; Single-pass membrane protein HAMAP MF_00319.

Sequence similarities

Belongs to the cdh family.

Sequence caution

The sequence CAA26358.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionCDP-diacylglycerol diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251CDP-diacylglycerol pyrophosphatase HAMAP MF_00319
PRO_0000198573

Regions

Transmembrane4 – 2421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P06282 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: F2E704FD5E164779

FASTA25128,451
        10         20         30         40         50         60 
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP 

        70         80         90        100        110        120 
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP 

       130        140        150        160        170        180 
DRAVSLAINS RTGRTQNHFH IHISCIRPDV RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR 

       190        200        210        220        230        240 
RVTESELVQR SPFMMLAEEV PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 

       250 
EIQDHQCEIL R 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli."
Icho T., Bulawa C.E., Raetz C.R.H.
J. Biol. Chem. 260:12092-12098(1985) [PubMed: 2995360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase."
Hellinga H.W., Evans P.R.
Eur. J. Biochem. 149:363-373(1985) [PubMed: 3158524] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 21:3391-3398(1993) [PubMed: 8346018] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11331 Genomic DNA. Translation: AAA23543.1.
X02519 Genomic DNA. Translation: CAA26358.1. Frameshift.
L19201 Genomic DNA. Translation: AAB03050.1.
U00096 Genomic DNA. Translation: AAC76900.1.
AP009048 Genomic DNA. Translation: BAE77392.1.
PIRPSECCD. A01019.
RefSeqNP_418353.1. NC_000913.2.

3D structure databases

ProteinModelPortalP06282.
SMRP06282. Positions 31-250.
ModBaseSearch...

Protein-protein interaction databases

IntActP06282. 3 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000004059; EBESCP00000004059; EBESCG00000003314.
EBESCT00000016198; EBESCP00000015489; EBESCG00000015258.
GeneID948410.
GenomeReviewsGene locus JW3889 in contig AP009048_GR.
Gene locus b3918 in contig U00096_GR.
KEGGecj:JW3889.
eco:b3918.
PATRIC32123349. VBIEscCol129921_4035.

Organism-specific databases

EchoBASEEB0136.
EcoGeneEG10138. cdh.

Phylogenomic databases

eggNOGCOG2134.
GeneTreeEBGT00050000011118.
HOGENOMHBG565233.
OMADINGPLQ.
PhylomeDBP06282.
ProtClustDBPRK05471.

Enzyme and pathway databases

BioCycEcoCyc:CDPDIGLYPYPHOSPHA-MONOMER.
MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER.

Gene expression databases

GenevestigatorP06282.

Family and domain databases

HAMAPMF_00319. Cdh.
[Tree]
InterProIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
[Graphical view]
KOK01521.
PfamPF02611. CDH. 1 hit.
[Graphical view]
PIRSFPIRSF001273. CDH. 1 hit.
TIGRFAMsTIGR00672. Cdh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDH_ECOLI
AccessionPrimary (citable) accession number: P06282
Secondary accession number(s): Q2M8L4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families