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Protein

CDP-diacylglycerol pyrophosphatase

Gene

cdh

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

CDP-diacylglycerol + H2O = CMP + phosphatidate.

Pathwayi: CDP-diacylglycerol degradation

This protein is involved in step 1 of the subpathway that synthesizes phosphatidate from CDP-diacylglycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. CDP-diacylglycerol pyrophosphatase (cdh)
This subpathway is part of the pathway CDP-diacylglycerol degradation, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidate from CDP-diacylglycerol, the pathway CDP-diacylglycerol degradation and in Phospholipid metabolism.

GO - Molecular functioni

  • CDP-diacylglycerol diphosphatase activity Source: EcoCyc

GO - Biological processi

  • CDP-diacylglycerol catabolic process Source: EcoCyc
  • phospholipid biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:CDPDIGLYPYPHOSPHA-MONOMER
MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER
UniPathwayiUPA00609; UER00664

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol pyrophosphatase (EC:3.6.1.26)
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene namesi
Name:cdh
Ordered Locus Names:b3918, JW3889
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10138 cdh

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001985731 – 251CDP-diacylglycerol pyrophosphataseAdd BLAST251

Proteomic databases

PaxDbiP06282
PRIDEiP06282

Interactioni

Protein-protein interaction databases

BioGridi4261218, 158 interactors
IntActiP06282, 3 interactors
STRINGi316385.ECDH10B_4107

Structurei

3D structure databases

ProteinModelPortaliP06282
SMRiP06282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdh family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EAF Bacteria
COG2134 LUCA
HOGENOMiHOG000048713
InParanoidiP06282
KOiK01521
OMAiSPFIMLA
PhylomeDBiP06282

Family and domain databases

Gene3Di3.30.428.30, 1 hit
HAMAPiMF_00319 Cdh, 1 hit
InterProiView protein in InterPro
IPR003763 CDP-diacylglyc_Pase
IPR015993 CDP-diacylglyc_Pase_proteobac
IPR038433 CDP-diacylglyc_Pase_sf
IPR036265 HIT-like_sf
PfamiView protein in Pfam
PF02611 CDH, 1 hit
PIRSFiPIRSF001273 CDH, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit
TIGRFAMsiTIGR00672 cdh, 1 hit

Sequencei

Sequence statusi: Complete.

P06282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ
60 70 80 90 100
NPSPCAEVKP NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF
110 120 130 140 150
FWLAWQARDF MSKKYGQPVP DRAVSLAINS RTGRTQNHFH IHISCIRPDV
160 170 180 190 200
RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR RVTESELVQR SPFMMLAEEV
210 220 230 240 250
PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE EIQDHQCEIL

R
Length:251
Mass (Da):28,451
Last modified:January 1, 1988 - v1
Checksum:iF2E704FD5E164779
GO

Sequence cautioni

The sequence CAA26358 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11331 Genomic DNA Translation: AAA23543.1
X02519 Genomic DNA Translation: CAA26358.1 Frameshift.
L19201 Genomic DNA Translation: AAB03050.1
U00096 Genomic DNA Translation: AAC76900.1
AP009048 Genomic DNA Translation: BAE77392.1
PIRiA01019 PSECCD
RefSeqiNP_418353.1, NC_000913.3
WP_001326656.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76900; AAC76900; b3918
BAE77392; BAE77392; BAE77392
GeneIDi948410
KEGGiecj:JW3889
eco:b3918
PATRICifig|1411691.4.peg.2787

Similar proteinsi

Entry informationi

Entry nameiCDH_ECOLI
AccessioniPrimary (citable) accession number: P06282
Secondary accession number(s): Q2M8L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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