P06282 (CDH_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26

Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	b3918, JW3889

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein HAMAP MF_00319.
Sequence similarities	Belongs to the cdh family.
Sequence caution	The sequence CAA26358.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198573
Regions
	Transmembrane	4 – 24	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P06282 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: F2E704FD5E164779	FASTA	251	28,451
	10 20 30 40 50 60 MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP 70 80 90 100 110 120 NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP 130 140 150 160 170 180 DRAVSLAINS RTGRTQNHFH IHISCIRPDV RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR 190 200 210 220 230 240 RVTESELVQR SPFMMLAEEV PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 250 EIQDHQCEIL R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli." Icho T., Bulawa C.E., Raetz C.R.H. J. Biol. Chem. 260:12092-12098(1985) [PubMed: 2995360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase." Hellinga H.W., Evans P.R. Eur. J. Biochem. 149:363-373(1985) [PubMed: 3158524] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Plunkett G. III, Burland V., Daniels D.L., Blattner F.R. Nucleic Acids Res. 21:3391-3398(1993) [PubMed: 8346018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11331 Genomic DNA. Translation: AAA23543.1. X02519 Genomic DNA. Translation: CAA26358.1. Frameshift. L19201 Genomic DNA. Translation: AAB03050.1. U00096 Genomic DNA. Translation: AAC76900.1. AP009048 Genomic DNA. Translation: BAE77392.1.
PIR	PSECCD. A01019.
RefSeq	NP_418353.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P06282.
SMR	P06282. Positions 31-250.
ModBase	Search...
Protein-protein interaction databases
IntAct	P06282. 3 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000004059; EBESCP00000004059; EBESCG00000003314. EBESCT00000016198; EBESCP00000015489; EBESCG00000015258.
GeneID	948410.
GenomeReviews	Gene locus JW3889 in contig AP009048_GR. Gene locus b3918 in contig U00096_GR.
KEGG	ecj:JW3889. eco:b3918.
PATRIC	32123349. VBIEscCol129921_4035.
Organism-specific databases
EchoBASE	EB0136.
EcoGene	EG10138. cdh.
Phylogenomic databases
eggNOG	COG2134.
GeneTree	EBGT00050000011118.
HOGENOM	HBG565233.
OMA	DINGPLQ.
PhylomeDB	P06282.
ProtClustDB	PRK05471.
Enzyme and pathway databases
BioCyc	EcoCyc:CDPDIGLYPYPHOSPHA-MONOMER. MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER.
Gene expression databases
Genevestigator	P06282.
Family and domain databases
HAMAP	MF_00319. Cdh. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
KO	K01521.
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. Cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_ECOLI

Accession

Primary (citable) accession number: P06282
Secondary accession number(s): Q2M8L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program