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Protein

Cell division control protein 7

Gene

CDC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.1 Publication

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76ATPPROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 47ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular protein complex localization Source: SGD
  • DNA replication initiation Source: SGD
  • double-strand break repair via break-induced replication Source: SGD
  • mitotic DNA replication checkpoint Source: SGD
  • mitotic DNA replication preinitiation complex assembly Source: SGD
  • negative regulation of exit from mitosis Source: SGD
  • peptidyl-serine phosphorylation Source: SGD
  • peptidyl-threonine phosphorylation Source: SGD
  • positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: SGD
  • positive regulation of meiosis I Source: SGD
  • positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Source: SGD
  • positive regulation of protein complex assembly Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Source: SGD
  • premeiotic DNA replication Source: SGD
  • protein autophosphorylation Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: GO_Central
  • regulation of chromatin silencing at telomere Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29446-MONOMER.
BRENDAi2.7.11.1. 984.
ReactomeiR-SCE-68962. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 7 (EC:2.7.11.1)
Gene namesi
Name:CDC7
Synonyms:OAF2
Ordered Locus Names:YDL017W
ORF Names:D2855
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL017W.
SGDiS000002175. CDC7.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: SGD
  • cytoplasm Source: GO_Central
  • Dbf4-dependent protein kinase complex Source: SGD
  • nucleus Source: SGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857661 – 507Cell division control protein 7Add BLAST507

Proteomic databases

MaxQBiP06243.
PRIDEiP06243.

PTM databases

iPTMnetiP06243.

Interactioni

Subunit structurei

Associates with DBF4 and ORC2.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32038. 392 interactors.
DIPiDIP-1235N.
IntActiP06243. 41 interactors.
MINTiMINT-385761.
STRINGi4932.YDL017W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T2SX-ray2.40B/D480-491[»]
ProteinModelPortaliP06243.
SMRiP06243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 469Protein kinasePROSITE-ProRule annotationAdd BLAST437

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075011.
HOGENOMiHOG000193450.
InParanoidiP06243.
KOiK02214.
OMAiILPYFRH.
OrthoDBiEOG092C2IG9.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 2 hits.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P06243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA
60 70 80 90 100
KDITGKITKK FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS
110 120 130 140 150
SRVAPLCDAK RVRDQVIAVL PYYPHEEFRT FYRDLPIKGI KKYIWELLRA
160 170 180 190 200
LKFVHSKGII HRDIKPTNFL FNLELGRGVL VDFGLAEAQM DYKSMISSQN
210 220 230 240 250
DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP PMVTIQNGKV
260 270 280 290 300
VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI
310 320 330 340 350
DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL
360 370 380 390 400
GFEASGLIWD KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ
410 420 430 440 450
QELHDRMSIE PQLPDPKTNM DAVDAYELKK YQEEIWSDHY WCFQVLEQCF
460 470 480 490 500
EMDPQKRSSA EDLLKTPFFN ELNENTYLLD GESTDEDDVV SSSEADLLDK

DVLLISE
Length:507
Mass (Da):58,320
Last modified:November 1, 1995 - v2
Checksum:iB74BA9144D0EC39F
GO

Sequence cautioni

The sequence CAA32370 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12624 Genomic DNA. Translation: AAA34485.1.
Z48432 Genomic DNA. Translation: CAA88342.1.
Z74065 Genomic DNA. Translation: CAA98574.1.
X14164 Genomic DNA. Translation: CAA32369.1.
X14164 Genomic DNA. Translation: CAA32370.1. Different initiation.
X15362 Genomic DNA. Translation: CAA33420.1.
BK006938 Genomic DNA. Translation: DAA11833.1.
PIRiA25228.
RefSeqiNP_010267.3. NM_001180076.3.

Genome annotation databases

EnsemblFungiiYDL017W; YDL017W; YDL017W.
GeneIDi851545.
KEGGisce:YDL017W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDC7_YEAST
AccessioniPrimary (citable) accession number: P06243
Secondary accession number(s): D6VRX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names