Cell division control protein 7 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P06243 (CDC7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 133. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cell division control protein 7
EC=2.7.11.1

Gene names

Name:	CDC7
Synonyms:	OAF2
Ordered Locus Names:	YDL017W
ORF Names:	D2855

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression. Ref.6
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Subunit structure	Associates with DBF4 and ORC2.
Miscellaneous	Present with 1600 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence CAA32370.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Meiosis Mitosis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication initiation Inferred from mutant phenotype PubMed 9472018. Source: SGD cell division Inferred from electronic annotation. Source: UniProtKB-KW double-strand break repair via break-induced replication Inferred from mutant phenotype PubMed 20516198. Source: SGD meiosis Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of exit from mitosis Inferred from physical interaction PubMed 19478884. Source: SGD regulation of chromatin silencing at telomere Inferred from mutant phenotype PubMed 16980387. Source: SGD
Cellular_component	Dbf4-dependent protein kinase complex Inferred from genetic interaction PubMed 8474449. Source: SGD nucleus Inferred from direct assay PubMed 2023904. Source: SGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from mutant phenotype Ref.6 PubMed 2023904 PubMed 2166954. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
itself		3	EBI-4451,EBI-4451
CDC5	P32562	11	EBI-4451,EBI-4440
DBF4	P32325	7	EBI-4451,EBI-5575
LRS4	Q04087	5	EBI-4451,EBI-32189

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 507

507

Cell division control protein 7

PRO_0000085766

Regions

Domain

33 – 469

437

Protein kinase

Nucleotide binding

39 – 47

ATP By similarity

Sites

Active site

163

Proton acceptor By similarity

Binding site

ATP By similarity

Amino acid modifications

Modified residue

198

Phosphoserine Ref.8

Sequences

Sequence

Length

Mass (Da)

Tools

P06243 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: B74BA9144D0EC39F
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FASTA

507

58,320

        10         20         30         40         50         60 
MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA KDITGKITKK 

        70         80         90        100        110        120 
FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS SRVAPLCDAK RVRDQVIAVL 

       130        140        150        160        170        180 
PYYPHEEFRT FYRDLPIKGI KKYIWELLRA LKFVHSKGII HRDIKPTNFL FNLELGRGVL 

       190        200        210        220        230        240 
VDFGLAEAQM DYKSMISSQN DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP 

       250        260        270        280        290        300 
PMVTIQNGKV VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI 

       310        320        330        340        350        360 
DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL GFEASGLIWD 

       370        380        390        400        410        420 
KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ QELHDRMSIE PQLPDPKTNM 

       430        440        450        460        470        480 
DAVDAYELKK YQEEIWSDHY WCFQVLEQCF EMDPQKRSSA EDLLKTPFFN ELNENTYLLD 

       490        500 
GESTDEDDVV SSSEADLLDK DVLLISE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae." Patterson M., Sclafani R.A., Fangman W.L., Rosamond J. Mol. Cell. Biol. 6:1590-1598(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P. Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Characterisation of the CDC7 gene product of Saccharomyces cerevisiae as a protein kinase needed for the initiation of mitotic DNA synthesis." Bahman M., Buck V., White A., Rosamond J. Biochim. Biophys. Acta 951:335-343(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138.
[5]	"Transcriptional analysis of the CDC7 protein kinase gene of Saccharomyces cerevisiae." Ham J., Moore D., Rosamond J., Johnston I.R. Nucleic Acids Res. 17:5781-5792(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27. Strain: ATCC 204508 / S288c.
[6]	"CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae." Buck V., Rosamond J. Mol. Gen. Genet. 227:452-457(1991) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M12624 Genomic DNA. Translation: AAA34485.1. Z48432 Genomic DNA. Translation: CAA88342.1. Z74065 Genomic DNA. Translation: CAA98574.1. X14164 Genomic DNA. Translation: CAA32369.1. X14164 Genomic DNA. Translation: CAA32370.1. Different initiation. X15362 Genomic DNA. Translation: CAA33420.1. BK006938 Genomic DNA. Translation: DAA11833.1.
PIR	A25228.
RefSeq	NP_010267.3. NM_001180076.3.
3D structure databases
ProteinModelPortal	P06243.
SMR	P06243. Positions 13-472.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1235N.
IntAct	P06243. 58 interactions.
MINT	MINT-385761.
STRING	4932.YDL017W.
Proteomic databases
PaxDb	P06243.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDL017W; YDL017W; YDL017W.
GeneID	851545.
KEGG	sce:YDL013W. sce:YDL017W.
Organism-specific databases
CYGD	YDL017w.
SGD	S000002175. CDC7.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00550000075011.
HOGENOM	HOG000193450.
KO	K02214.
OMA	YVTSSPN.
OrthoDB	EOG4N8VDB.
Enzyme and pathway databases
BRENDA	2.7.11.1. 984.
Gene expression databases
Genevestigator	P06243.
GermOnline	YDL017W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 2 hits. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968958.

Entry information

Entry name

CDC7_YEAST

Accession

Primary (citable) accession number: P06243
Secondary accession number(s): D6VRX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents