##gff-version 3
P06240	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P06240	UniProtKB	Chain	2	509	.	.	.	ID=PRO_0000088125;Note=Proto-oncogene tyrosine-protein kinase LCK	
P06240	UniProtKB	Domain	61	121	.	.	.	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192	
P06240	UniProtKB	Domain	127	224	.	.	.	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191	
P06240	UniProtKB	Domain	245	498	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P06240	UniProtKB	Region	2	72	.	.	.	Note=Interactions with CD4 and CD8	
P06240	UniProtKB	Region	154	242	.	.	.	Note=Interaction with PTPRH;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P06240	UniProtKB	Active site	364	364	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028	
P06240	UniProtKB	Binding site	251	259	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P06240	UniProtKB	Binding site	273	273	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P06240	UniProtKB	Modified residue	102	102	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Modified residue	159	159	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Modified residue	162	162	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Modified residue	192	192	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P06240	UniProtKB	Modified residue	194	194	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Modified residue	394	394	.	.	.	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Modified residue	505	505	.	.	.	Note=Phosphotyrosine%3B by CSK;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06239	
P06240	UniProtKB	Lipidation	2	2	.	.	.	Note=N-myristoyl glycine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:7980442;Dbxref=PMID:7980442	
P06240	UniProtKB	Lipidation	3	3	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7980442,ECO:0000269|PubMed:8413237;Dbxref=PMID:7980442,PMID:8413237	
P06240	UniProtKB	Lipidation	5	5	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7980442,ECO:0000269|PubMed:8413237;Dbxref=PMID:7980442,PMID:8413237	
P06240	UniProtKB	Mutagenesis	2	2	.	.	.	Note=Abolishes myristoylation and palmitoylation. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7980442;Dbxref=PMID:7980442	
P06240	UniProtKB	Mutagenesis	3	5	.	.	.	Note=Complete loss of interaction with CD4 or CD8. CVC->SVK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2107025;Dbxref=PMID:2107025	
P06240	UniProtKB	Mutagenesis	3	3	.	.	.	Note=Abolishes plasma membrane association%3B when associated with S-41. Reduced palmitoylation level. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7980442,ECO:0000269|PubMed:8413237;Dbxref=PMID:7980442,PMID:8413237	
P06240	UniProtKB	Mutagenesis	5	5	.	.	.	Note=Reduced palmitoylation level. C->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7980442,ECO:0000269|PubMed:8413237;Dbxref=PMID:7980442,PMID:8413237	
P06240	UniProtKB	Mutagenesis	5	5	.	.	.	Note=Abolishes plasma membrane association%3B when associated with S-21. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7980442,ECO:0000269|PubMed:8413237;Dbxref=PMID:7980442,PMID:8413237	
P06240	UniProtKB	Mutagenesis	20	20	.	.	.	Note=Complete loss of interaction with CD4 or CD8. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2107025;Dbxref=PMID:2107025	
P06240	UniProtKB	Mutagenesis	23	23	.	.	.	Note=Complete loss of interaction with CD4 or CD8. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2107025;Dbxref=PMID:2107025	
P06240	UniProtKB	Mutagenesis	269	269	.	.	.	Note=Reduced activity. K->N	
P06240	UniProtKB	Mutagenesis	270	270	.	.	.	Note=Reduced activity. V->L	
P06240	UniProtKB	Mutagenesis	271	271	.	.	.	Note=Reduced activity. A->S	
P06240	UniProtKB	Mutagenesis	272	272	.	.	.	Note=Reduced activity. V->A	
P06240	UniProtKB	Mutagenesis	273	273	.	.	.	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1706070;Dbxref=PMID:1706070	
P06240	UniProtKB	Mutagenesis	274	274	.	.	.	Note=Reduced activity. S->N	
P06240	UniProtKB	Mutagenesis	275	275	.	.	.	Note=Reduced activity. L->M	
P06240	UniProtKB	Mutagenesis	276	276	.	.	.	Note=Reduced activity. K->V	
P06240	UniProtKB	Mutagenesis	505	505	.	.	.	Note=Causes thymic tumors. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1708890,ECO:0000269|PubMed:3380790;Dbxref=PMID:1708890,PMID:3380790