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Protein

Estrogen receptor

Gene

ESR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi179 – 24466Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 19921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of gene expression Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:ESR1
Synonyms:ESR, NR3A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Estrogen receptorPRO_0000053625Add
BLAST

Proteomic databases

PaxDbiP06212.

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta.

GO - Molecular functioni

  • Hsp90 protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021137.

Structurei

3D structure databases

ProteinModelPortaliP06212.
SMRiP06212. Positions 174-247, 295-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 178178Modulating (transactivation AF-1)Add
BLAST
Regioni245 – 30460HingeAdd
BLAST
Regioni305 – 589285Transactivation AF-2By similarityAdd
BLAST
Regioni305 – 545241Steroid-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri179 – 19921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiP06212.
KOiK08550.
PhylomeDBiP06212.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG
60 70 80 90 100
VFNYPEGATY DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS
110 120 130 140 150
PVVFLQTAPQ LSPFIHHHSQ QVPYYLENEQ GSFGMREAAP PAFYRPSSDN
160 170 180 190 200
RRHSIRERMS STNEKGSLSM ESTKETRYCA VCNDYASGYH YGVWSCEGCK
210 220 230 240 250
AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY EVGMMKGGIR
260 270 280 290 300
KDRRGGEMMK QKRQREEQDS RNGEASSTEL RAPTLWTSPL VVKHNKKNSP
310 320 330 340 350
ALSLTAEQMV SALLEAEPPI VYSEYDPNRP FNEASMMTLL TNLADRELVH
360 370 380 390 400
MINWAKRVPG FVDLTLHDQV HLLECAWLEI LMIGLVWRSM EHPGKLLFAP
410 420 430 440 450
NLLLDRNQGK CVEGMVEIFD MLLATAARFR MMNLQGEEFV CLKSIILLNS
460 470 480 490 500
GVYTFLSSTL KSLEERDYIH RVLDKITDTL IHLMAKSGLS LQQQHRRLAQ
510 520 530 540 550
LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPAARS
560 570 580
AAPMEEENRN QLTTAPASSH SLQSFYINSK EEESMQNTI
Length:589
Mass (Da):66,746
Last modified:January 1, 1988 - v1
Checksum:i1B092233C770A54B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571E → R (PubMed:2901032).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03805 mRNA. Translation: CAA27433.1.
PIRiA40914. QRCHE.
RefSeqiNP_990514.1. NM_205183.2.
UniGeneiGga.650.

Genome annotation databases

GeneIDi396099.
KEGGigga:396099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03805 mRNA. Translation: CAA27433.1.
PIRiA40914. QRCHE.
RefSeqiNP_990514.1. NM_205183.2.
UniGeneiGga.650.

3D structure databases

ProteinModelPortaliP06212.
SMRiP06212. Positions 174-247, 295-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021137.

Proteomic databases

PaxDbiP06212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396099.
KEGGigga:396099.

Organism-specific databases

CTDi2099.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiP06212.
KOiK08550.
PhylomeDBiP06212.

Miscellaneous databases

NextBioi20816157.
PROiP06212.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors."
    Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J.-M., Chambon P.
    EMBO J. 5:891-897(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural organization and regulation of the chicken estrogen receptor."
    Maxwell B.L., McDonnell D.P., Conneely O.M., Schulz T.Z., Greene G.L., O'Malley B.W.
    Mol. Endocrinol. 1:25-35(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiESR1_CHICK
AccessioniPrimary (citable) accession number: P06212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 11, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.