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Protein

Periplasmic oligopeptide-binding protein

Gene

oppA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3142-MONOMER.
SENT99287:GCTI-1755-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic oligopeptide-binding protein
Gene namesi
Name:oppA
Ordered Locus Names:STM1746
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 543517Periplasmic oligopeptide-binding proteinPRO_0000031798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi297 ↔ 443

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP06202.
PRIDEiP06202.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1746.S.

Structurei

Secondary structure

1
543
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 445Combined sources
Turni54 – 563Combined sources
Helixi60 – 6910Combined sources
Beta strandi73 – 764Combined sources
Beta strandi82 – 9312Combined sources
Turni94 – 963Combined sources
Beta strandi97 – 1026Combined sources
Helixi116 – 12712Combined sources
Helixi129 – 1313Combined sources
Turni134 – 1374Combined sources
Helixi138 – 1414Combined sources
Helixi147 – 1515Combined sources
Helixi157 – 1593Combined sources
Beta strandi160 – 1667Combined sources
Beta strandi169 – 1768Combined sources
Helixi181 – 1844Combined sources
Helixi188 – 1903Combined sources
Helixi195 – 2017Combined sources
Helixi202 – 2043Combined sources
Turni208 – 2103Combined sources
Beta strandi215 – 2239Combined sources
Turni224 – 2263Combined sources
Beta strandi227 – 2326Combined sources
Helixi239 – 2413Combined sources
Beta strandi246 – 2505Combined sources
Helixi255 – 2639Combined sources
Turni276 – 2783Combined sources
Helixi279 – 2857Combined sources
Helixi287 – 2893Combined sources
Beta strandi290 – 30314Combined sources
Turni308 – 3114Combined sources
Helixi313 – 32210Combined sources
Helixi325 – 3306Combined sources
Turni331 – 3333Combined sources
Beta strandi341 – 3444Combined sources
Helixi357 – 3604Combined sources
Helixi363 – 37614Combined sources
Beta strandi381 – 3833Combined sources
Beta strandi386 – 3938Combined sources
Helixi395 – 41218Combined sources
Beta strandi415 – 4217Combined sources
Helixi423 – 43210Combined sources
Beta strandi436 – 4438Combined sources
Beta strandi445 – 4484Combined sources
Helixi450 – 4534Combined sources
Helixi454 – 4563Combined sources
Helixi470 – 4789Combined sources
Turni479 – 4813Combined sources
Beta strandi482 – 4843Combined sources
Helixi485 – 50117Combined sources
Beta strandi505 – 51713Combined sources
Beta strandi521 – 5233Combined sources
Helixi535 – 5373Combined sources
Beta strandi539 – 5413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B05X-ray2.00A27-543[»]
1B0HX-ray1.90A27-543[»]
1B1HX-ray1.80A27-543[»]
1B2HX-ray1.90A27-543[»]
1B32X-ray1.75A27-543[»]
1B3FX-ray1.80A27-543[»]
1B3GX-ray2.00A27-543[»]
1B3HX-ray2.00A27-543[»]
1B3LX-ray2.00A/C27-543[»]
1B40X-ray2.20A27-543[»]
1B46X-ray1.80A27-543[»]
1B4HX-ray1.90A27-543[»]
1B4ZX-ray1.75A27-543[»]
1B51X-ray1.80A27-543[»]
1B52X-ray2.30A27-543[»]
1B58X-ray1.80A27-543[»]
1B5HX-ray1.90A27-543[»]
1B5IX-ray1.90A27-543[»]
1B5JX-ray1.80A27-543[»]
1B6HX-ray1.80A27-543[»]
1B7HX-ray2.00A27-543[»]
1B9JX-ray1.80A27-543[»]
1JETX-ray1.20A27-543[»]
1JEUX-ray1.25A27-543[»]
1JEVX-ray1.30A27-543[»]
1OLAX-ray2.10A27-543[»]
1OLCX-ray2.10A27-543[»]
1QKAX-ray1.80A27-543[»]
1QKBX-ray1.80A27-543[»]
1RKMX-ray2.40A27-543[»]
2OLBX-ray1.40A27-543[»]
2RKMX-ray1.80A27-543[»]
ProteinModelPortaliP06202.
SMRiP06202. Positions 27-543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06202.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107QSI. Bacteria.
COG4166. LUCA.
KOiK15580.
OMAiMSIITKK.
PhylomeDBiP06202.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITKKSLI AAGILTALIA ASAATAADVP AGVQLADKQT LVRNNGSEVQ
60 70 80 90 100
SLDPHKIEGV PESNVSRDLF EGLLISDVEG HPSPGVAEKW ENKDFKVWTF
110 120 130 140 150
HLRENAKWSD GTPVTAHDFV YSWQRLADPN TASPYASYLQ YGHIANIDDI
160 170 180 190 200
IAGKKPATDL GVKALDDHTF EVTLSEPVPY FYKLLVHPSV SPVPKSAVEK
210 220 230 240 250
FGDKWTQPAN IVTNGAYKLK NWVVNERIVL ERNPQYWDNA KTVINQVTYL
260 270 280 290 300
PISSEVTDVN RYRSGEIDMT YNNMPIELFQ KLKKEIPNEV RVDPYLCTYY
310 320 330 340 350
YEINNQKAPF NDVRVRTALK LALDRDIIVN KVKNQGDLPA YSYTPPYTDG
360 370 380 390 400
AKLVEPEWFK WSQQKRNEEA KKLLAEAGFT ADKPLTFDLL YNTSDLHKKL
410 420 430 440 450
AIAVASIWKK NLGVNVNLEN QEWKTFLDTR HQGTFDVARA GWCADYNEPT
460 470 480 490 500
SFLNTMLSDS SNNTAHYKSP AFDKLIADTL KVADDTQRSE LYAKAEQQLD
510 520 530 540
KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNIYVKNLYI IKH
Length:543
Mass (Da):61,292
Last modified:January 23, 2002 - v2
Checksum:iEF344E7C7991CA47
GO

Sequence cautioni

The sequence AAL20664 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 243SAA → TP (PubMed:2821267).Curated
Sequence conflicti22 – 243SAA → TP (PubMed:3525163).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04194 Genomic DNA. Translation: CAA27785.1.
X05491 Genomic DNA. Translation: CAA29039.1.
AE006468 Genomic DNA. Translation: AAL20664.1. Different initiation.
PIRiA25011. QREBOA.
RefSeqiNP_460705.2. NC_003197.1.
WP_001521098.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20664; AAL20664; STM1746.
GeneIDi1253265.
KEGGistm:STM1746.S.
PATRICi32382007. VBISalEnt20916_1843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04194 Genomic DNA. Translation: CAA27785.1.
X05491 Genomic DNA. Translation: CAA29039.1.
AE006468 Genomic DNA. Translation: AAL20664.1. Different initiation.
PIRiA25011. QREBOA.
RefSeqiNP_460705.2. NC_003197.1.
WP_001521098.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B05X-ray2.00A27-543[»]
1B0HX-ray1.90A27-543[»]
1B1HX-ray1.80A27-543[»]
1B2HX-ray1.90A27-543[»]
1B32X-ray1.75A27-543[»]
1B3FX-ray1.80A27-543[»]
1B3GX-ray2.00A27-543[»]
1B3HX-ray2.00A27-543[»]
1B3LX-ray2.00A/C27-543[»]
1B40X-ray2.20A27-543[»]
1B46X-ray1.80A27-543[»]
1B4HX-ray1.90A27-543[»]
1B4ZX-ray1.75A27-543[»]
1B51X-ray1.80A27-543[»]
1B52X-ray2.30A27-543[»]
1B58X-ray1.80A27-543[»]
1B5HX-ray1.90A27-543[»]
1B5IX-ray1.90A27-543[»]
1B5JX-ray1.80A27-543[»]
1B6HX-ray1.80A27-543[»]
1B7HX-ray2.00A27-543[»]
1B9JX-ray1.80A27-543[»]
1JETX-ray1.20A27-543[»]
1JEUX-ray1.25A27-543[»]
1JEVX-ray1.30A27-543[»]
1OLAX-ray2.10A27-543[»]
1OLCX-ray2.10A27-543[»]
1QKAX-ray1.80A27-543[»]
1QKBX-ray1.80A27-543[»]
1RKMX-ray2.40A27-543[»]
2OLBX-ray1.40A27-543[»]
2RKMX-ray1.80A27-543[»]
ProteinModelPortaliP06202.
SMRiP06202. Positions 27-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1746.S.

Protein family/group databases

TCDBi3.A.1.5.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP06202.
PRIDEiP06202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20664; AAL20664; STM1746.
GeneIDi1253265.
KEGGistm:STM1746.S.
PATRICi32382007. VBISalEnt20916_1843.

Phylogenomic databases

eggNOGiENOG4107QSI. Bacteria.
COG4166. LUCA.
KOiK15580.
OMAiMSIITKK.
PhylomeDBiP06202.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3142-MONOMER.
SENT99287:GCTI-1755-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP06202.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPPA_SALTY
AccessioniPrimary (citable) accession number: P06202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2002
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.