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Protein

Periplasmic oligopeptide-binding protein

Gene

oppA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Protein family/group databases

TCDBi3.A.1.5.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic oligopeptide-binding protein
Gene namesi
Name:oppA
Ordered Locus Names:STM1746
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000003179827 – 543Periplasmic oligopeptide-binding proteinAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi297 ↔ 443

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP06202.
PRIDEiP06202.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1746.S.

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 44Combined sources5
Turni54 – 56Combined sources3
Helixi60 – 69Combined sources10
Beta strandi73 – 76Combined sources4
Beta strandi82 – 93Combined sources12
Turni94 – 96Combined sources3
Beta strandi97 – 102Combined sources6
Helixi116 – 127Combined sources12
Helixi129 – 131Combined sources3
Turni134 – 137Combined sources4
Helixi138 – 141Combined sources4
Helixi147 – 151Combined sources5
Helixi157 – 159Combined sources3
Beta strandi160 – 166Combined sources7
Beta strandi169 – 176Combined sources8
Helixi181 – 184Combined sources4
Helixi188 – 190Combined sources3
Helixi195 – 201Combined sources7
Helixi202 – 204Combined sources3
Turni208 – 210Combined sources3
Beta strandi215 – 223Combined sources9
Turni224 – 226Combined sources3
Beta strandi227 – 232Combined sources6
Helixi239 – 241Combined sources3
Beta strandi246 – 250Combined sources5
Helixi255 – 263Combined sources9
Turni276 – 278Combined sources3
Helixi279 – 285Combined sources7
Helixi287 – 289Combined sources3
Beta strandi290 – 303Combined sources14
Turni308 – 311Combined sources4
Helixi313 – 322Combined sources10
Helixi325 – 330Combined sources6
Turni331 – 333Combined sources3
Beta strandi341 – 344Combined sources4
Helixi357 – 360Combined sources4
Helixi363 – 376Combined sources14
Beta strandi381 – 383Combined sources3
Beta strandi386 – 393Combined sources8
Helixi395 – 412Combined sources18
Beta strandi415 – 421Combined sources7
Helixi423 – 432Combined sources10
Beta strandi436 – 443Combined sources8
Beta strandi445 – 448Combined sources4
Helixi450 – 453Combined sources4
Helixi454 – 456Combined sources3
Helixi470 – 478Combined sources9
Turni479 – 481Combined sources3
Beta strandi482 – 484Combined sources3
Helixi485 – 501Combined sources17
Beta strandi505 – 517Combined sources13
Beta strandi521 – 523Combined sources3
Helixi535 – 537Combined sources3
Beta strandi539 – 541Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B05X-ray2.00A27-543[»]
1B0HX-ray1.90A27-543[»]
1B1HX-ray1.80A27-543[»]
1B2HX-ray1.90A27-543[»]
1B32X-ray1.75A27-543[»]
1B3FX-ray1.80A27-543[»]
1B3GX-ray2.00A27-543[»]
1B3HX-ray2.00A27-543[»]
1B3LX-ray2.00A/C27-543[»]
1B40X-ray2.20A27-543[»]
1B46X-ray1.80A27-543[»]
1B4HX-ray1.90A27-543[»]
1B4ZX-ray1.75A27-543[»]
1B51X-ray1.80A27-543[»]
1B52X-ray2.30A27-543[»]
1B58X-ray1.80A27-543[»]
1B5HX-ray1.90A27-543[»]
1B5IX-ray1.90A27-543[»]
1B5JX-ray1.80A27-543[»]
1B6HX-ray1.80A27-543[»]
1B7HX-ray2.00A27-543[»]
1B9JX-ray1.80A27-543[»]
1JETX-ray1.20A27-543[»]
1JEUX-ray1.25A27-543[»]
1JEVX-ray1.30A27-543[»]
1OLAX-ray2.10A27-543[»]
1OLCX-ray2.10A27-543[»]
1QKAX-ray1.80A27-543[»]
1QKBX-ray1.80A27-543[»]
1RKMX-ray2.40A27-543[»]
2OLBX-ray1.40A27-543[»]
2RKMX-ray1.80A27-543[»]
ProteinModelPortaliP06202.
SMRiP06202.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06202.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107QSI. Bacteria.
COG4166. LUCA.
KOiK15580.
OMAiMSIITKK.
PhylomeDBiP06202.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITKKSLI AAGILTALIA ASAATAADVP AGVQLADKQT LVRNNGSEVQ
60 70 80 90 100
SLDPHKIEGV PESNVSRDLF EGLLISDVEG HPSPGVAEKW ENKDFKVWTF
110 120 130 140 150
HLRENAKWSD GTPVTAHDFV YSWQRLADPN TASPYASYLQ YGHIANIDDI
160 170 180 190 200
IAGKKPATDL GVKALDDHTF EVTLSEPVPY FYKLLVHPSV SPVPKSAVEK
210 220 230 240 250
FGDKWTQPAN IVTNGAYKLK NWVVNERIVL ERNPQYWDNA KTVINQVTYL
260 270 280 290 300
PISSEVTDVN RYRSGEIDMT YNNMPIELFQ KLKKEIPNEV RVDPYLCTYY
310 320 330 340 350
YEINNQKAPF NDVRVRTALK LALDRDIIVN KVKNQGDLPA YSYTPPYTDG
360 370 380 390 400
AKLVEPEWFK WSQQKRNEEA KKLLAEAGFT ADKPLTFDLL YNTSDLHKKL
410 420 430 440 450
AIAVASIWKK NLGVNVNLEN QEWKTFLDTR HQGTFDVARA GWCADYNEPT
460 470 480 490 500
SFLNTMLSDS SNNTAHYKSP AFDKLIADTL KVADDTQRSE LYAKAEQQLD
510 520 530 540
KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNIYVKNLYI IKH
Length:543
Mass (Da):61,292
Last modified:January 23, 2002 - v2
Checksum:iEF344E7C7991CA47
GO

Sequence cautioni

The sequence AAL20664 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 24SAA → TP (PubMed:2821267).Curated3
Sequence conflicti22 – 24SAA → TP (PubMed:3525163).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04194 Genomic DNA. Translation: CAA27785.1.
X05491 Genomic DNA. Translation: CAA29039.1.
AE006468 Genomic DNA. Translation: AAL20664.1. Different initiation.
PIRiA25011. QREBOA.
RefSeqiNP_460705.2. NC_003197.1.
WP_001521098.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20664; AAL20664; STM1746.
GeneIDi1253265.
KEGGistm:STM1746.S.
PATRICi32382007. VBISalEnt20916_1843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04194 Genomic DNA. Translation: CAA27785.1.
X05491 Genomic DNA. Translation: CAA29039.1.
AE006468 Genomic DNA. Translation: AAL20664.1. Different initiation.
PIRiA25011. QREBOA.
RefSeqiNP_460705.2. NC_003197.1.
WP_001521098.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B05X-ray2.00A27-543[»]
1B0HX-ray1.90A27-543[»]
1B1HX-ray1.80A27-543[»]
1B2HX-ray1.90A27-543[»]
1B32X-ray1.75A27-543[»]
1B3FX-ray1.80A27-543[»]
1B3GX-ray2.00A27-543[»]
1B3HX-ray2.00A27-543[»]
1B3LX-ray2.00A/C27-543[»]
1B40X-ray2.20A27-543[»]
1B46X-ray1.80A27-543[»]
1B4HX-ray1.90A27-543[»]
1B4ZX-ray1.75A27-543[»]
1B51X-ray1.80A27-543[»]
1B52X-ray2.30A27-543[»]
1B58X-ray1.80A27-543[»]
1B5HX-ray1.90A27-543[»]
1B5IX-ray1.90A27-543[»]
1B5JX-ray1.80A27-543[»]
1B6HX-ray1.80A27-543[»]
1B7HX-ray2.00A27-543[»]
1B9JX-ray1.80A27-543[»]
1JETX-ray1.20A27-543[»]
1JEUX-ray1.25A27-543[»]
1JEVX-ray1.30A27-543[»]
1OLAX-ray2.10A27-543[»]
1OLCX-ray2.10A27-543[»]
1QKAX-ray1.80A27-543[»]
1QKBX-ray1.80A27-543[»]
1RKMX-ray2.40A27-543[»]
2OLBX-ray1.40A27-543[»]
2RKMX-ray1.80A27-543[»]
ProteinModelPortaliP06202.
SMRiP06202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1746.S.

Protein family/group databases

TCDBi3.A.1.5.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP06202.
PRIDEiP06202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20664; AAL20664; STM1746.
GeneIDi1253265.
KEGGistm:STM1746.S.
PATRICi32382007. VBISalEnt20916_1843.

Phylogenomic databases

eggNOGiENOG4107QSI. Bacteria.
COG4166. LUCA.
KOiK15580.
OMAiMSIITKK.
PhylomeDBiP06202.

Miscellaneous databases

EvolutionaryTraceiP06202.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPPA_SALTY
AccessioniPrimary (citable) accession number: P06202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.