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Protein

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Gene

PIS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Myo-inositol-containing phospholipids are of crucial importance in the control of cellular functions.
Present with 3810 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.

GO - Molecular functioni

  • CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity Source: SGD

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: SGD

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YPR113W-MONOMER
YEAST:YPR113W-MONOMER
ReactomeiR-SCE-1483226 Synthesis of PI

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11)
Alternative name(s):
Phosphatidylinositol synthase
Short name:
PI synthase
Short name:
PtdIns synthase
Gene namesi
Name:PIS1
Synonyms:PIS
Ordered Locus Names:YPR113W
ORF Names:P8283.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR113W
SGDiS000006317 PIS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 45Lumenal1 Publication4
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 75Cytoplasmic1 Publication9
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 98Lumenal1 Publication2
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 145Cytoplasmic1 PublicationAdd BLAST26
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 170Lumenal1 Publication4
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 220Cytoplasmic1 PublicationAdd BLAST29

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568071 – 220CDP-diacylglycerol--inositol 3-phosphatidyltransferaseAdd BLAST220

Proteomic databases

MaxQBiP06197
PaxDbiP06197
PRIDEiP06197

Interactioni

Protein-protein interaction databases

BioGridi36280, 52 interactors
DIPiDIP-3815N
IntActiP06197, 33 interactors
MINTiP06197
STRINGi4932.YPR113W

Structurei

3D structure databases

ProteinModelPortaliP06197
SMRiP06197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017279
HOGENOMiHOG000204051
InParanoidiP06197
KOiK00999
OMAiLWITAPI
OrthoDBiEOG092C5EEC

Family and domain databases

InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR014387 CDP_diag_ino_3_P_euk
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000848 CDP_diag_ino_3_P, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequencei

Sequence statusi: Complete.

P06197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSTPEKV TAEHVLWYIP NKIGYVRVIT AALSFFVMKN HPTAFTWLYS
60 70 80 90 100
TSCLLDALDG TMARKYNQVS SLGAVLDMVT DRSSTAGLMC FLCVQYPQWC
110 120 130 140 150
VFFQLMLGLD ITSHYMHMYA SLSAGKTSHK SVGEGESRLL HLYYTRRDVL
160 170 180 190 200
FTICAFNELF YAGLYLQLFS NSATFGKWTT IISFPGYVFK QTANVVQLKR
210 220
AALILADNDA KNANEKNKTY
Length:220
Mass (Da):24,824
Last modified:January 1, 1988 - v1
Checksum:i6E2E62252B3CB5E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02697 Genomic DNA Translation: AAA34876.1
U32445 Genomic DNA Translation: AAB68083.1
BK006949 Genomic DNA Translation: DAA11528.1
PIRiA27409
RefSeqiNP_015438.1, NM_001184210.1

Genome annotation databases

EnsemblFungiiYPR113W; YPR113W; YPR113W
GeneIDi856229
KEGGisce:YPR113W

Similar proteinsi

Entry informationi

Entry nameiPIS_YEAST
AccessioniPrimary (citable) accession number: P06197
Secondary accession number(s): D6W4B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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