Reviewed, UniProtKB/Swiss-Prot P06195 (PABA_SERMA)

Names and origin

Protein names

Recommended name:
    Para-aminobenzoate synthase glutamine amidotransferase component II
    EC=2.6.1.85
Alternative name(s):
    ADC synthase

Gene names

Name:

pabA

Organism

Serratia marcescens

Taxonomic identifier

615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC anthranilate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Para-aminobenzoate synthase glutamine amidotransferase component II		PRO_0000056852
Regions
	Domain	1 – 191	191	Glutamine amidotransferase type-1
Sites
	Active site	79	1	By similarity
	Active site	172	1	By similarity
	Active site	174	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06195-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: F1063CC327BEF3E3	FASTA	191	21,143
	10 20 30 40 50 60 MLLLIDNYDS FTYNLYQYFC ELGAEVVVKR NDELQLTDIE RLAPQHLVIS PGPCTPNEAG 70 80 90 100 110 120 ISVAAIRHFA GKLPILGVCL GHQALGQAFG AEVVRARAVM HGKTSAIRHL GVGVFRGLSD 130 140 150 160 170 180 PLTVTRYHSL VLKADTLPDC FEVTAWSERD GVRDEIMGIR HRALALEGVQ FHPESVLSEQ 190 GHQLLDNFLN R

References

[1]

"Evolution of glutamine amidotransferase genes. Nucleotide sequences of the pabA genes from Salmonella typhimurium, Klebsiella aerogenes and Serratia marcescens." Kaplan J.B., Merkel W.K., Nichols B.P. J. Mol. Biol. 183:327-340(1985) [PubMed: 3894673] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02605 Genomic DNA. Translation: CAA26452.1.
PIR	S09635.
3D structure databases
SMR	P06195. Positions 1-191.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.85. 457.
Family and domain databases
InterPro	IPR006220. Anth_synthII. IPR001317. CarbamoylP_synth_GATase_dom. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR006221. TrpG_papA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. [Graphical view]
PRINTS	PR00097. ANTSNTHASEII. PR00099. CPSGATASE. PR00096. GATASE.
TIGRFAMs	TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABA_SERMA

Accession

Primary (citable) accession number: P06195

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)