Reviewed, UniProtKB/Swiss-Prot P06194 (PABA_KLEAE)

Names and origin

Protein names

Recommended name:
    Para-aminobenzoate synthase glutamine amidotransferase component II
    EC=2.6.1.85
Alternative name(s):
    ADC synthase

Gene names

Name:

pabA

Organism

Klebsiella aerogenes

Taxonomic identifier

28451 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC anthranilate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Para-aminobenzoate synthase glutamine amidotransferase component II		PRO_0000056850
Regions
	Domain	1 – 187	187	Glutamine amidotransferase type-1
Sites
	Active site	79	1	By similarity
	Active site	168	1	By similarity
	Active site	170	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06194-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 89997A6C05E10B79	FASTA	187	20,564
	10 20 30 40 50 60 MILLIDNYDS FTWNLYQYFC ELGAEVLVRR NDELTLADII SLAPAKIVIS PGPCTPDESG 70 80 90 100 110 120 ISLAAIRHFS GQTPILGVCL GHQAIAQVFG AAIVRAAKVM HGKTSPVSHT GQGVFLGLNN 130 140 150 160 170 180 PLTVTRYHSL LIDPRTLPEC FEVTARSEEG EIMGIRHRVF DLEGVQFHPE SILSEQGHQL LANFLNR

References

[1]

"Evolution of glutamine amidotransferase genes. Nucleotide sequences of the pabA genes from Salmonella typhimurium, Klebsiella aerogenes and Serratia marcescens." Kaplan J.B., Merkel W.K., Nichols B.P. J. Mol. Biol. 183:327-340(1985) [PubMed: 3894673] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X02604 Genomic DNA. Translation: CAA26451.1.
3D structure databases
HSSP	HSSP built from PDB template 1I1Q based on UniProtKB P00905.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.85. 366.
Family and domain databases
InterPro	IPR006220. Anth_synthII. IPR001317. CarbamoylP_synth_GATase. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR006221. TrpG_papA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. [Graphical view]
PRINTS	PR00097. ANTSNTHASEII. PR00099. CPSGATASE. PR00096. GATASE.
TIGRFAMs	TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABA_KLEAE

Accession

Primary (citable) accession number: P06194

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)