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Reviewed, UniProtKB/Swiss-Prot P06194 (PABA_KLEAE)

Last modified June 16, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Para-aminobenzoate synthase glutamine amidotransferase component II
    EC=2.6.1.85
Alternative name(s):
    ADC synthase
Gene names
Name: pabA
OrganismKlebsiella aerogenes
Taxonomic identifier28451 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

General annotation (Comments)

Function

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.

Catalytic activity

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.

Subunit structure

Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Para-aminobenzoate synthase glutamine amidotransferase component II
PRO_0000056850

Regions

Domain1 – 187187Glutamine amidotransferase type-1

Sites

Active site791 By similarity
Active site1681 By similarity
Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P06194-1 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 89997A6C05E10B79

FASTA18720,564
        10         20         30         40         50         60 
MILLIDNYDS FTWNLYQYFC ELGAEVLVRR NDELTLADII SLAPAKIVIS PGPCTPDESG 

        70         80         90        100        110        120 
ISLAAIRHFS GQTPILGVCL GHQAIAQVFG AAIVRAAKVM HGKTSPVSHT GQGVFLGLNN 

       130        140        150        160        170        180 
PLTVTRYHSL LIDPRTLPEC FEVTARSEEG EIMGIRHRVF DLEGVQFHPE SILSEQGHQL 


LANFLNR 

« Hide

References

[1]"Evolution of glutamine amidotransferase genes. Nucleotide sequences of the pabA genes from Salmonella typhimurium, Klebsiella aerogenes and Serratia marcescens."
Kaplan J.B., Merkel W.K., Nichols B.P.
J. Mol. Biol. 183:327-340(1985) [PubMed: 3894673] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

X02604 Genomic DNA. Translation: CAA26451.1.

3D structure databases

HSSPHSSP built from PDB template 1I1Q based on UniProtKB P00905.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.6.1.85. 366.

Family and domain databases

InterProIPR006220. Anth_synthII.
IPR001317. CarbamoylP_synth_GATase.
IPR011702. GATASE.
IPR017926. GATASE_1.
IPR000991. GATase_class1_C.
IPR006221. TrpG_papA.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
PRINTSPR00097. ANTSNTHASEII.
PR00099. CPSGATASE.
PR00096. GATASE.
TIGRFAMsTIGR00566. trpG_papA. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePABA_KLEAE
AccessionPrimary (citable) accession number: P06194
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents