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Protein

Aminodeoxychorismate synthase component 2

Gene

pabA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB (By similarity).By similarity

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Aminodeoxychorismate synthase component 1 (pabB), Aminodeoxychorismate synthase component 2 (pabA)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791PROSITE-ProRule annotation
Active sitei168 – 1681PROSITE-ProRule annotation
Active sitei170 – 1701PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Folate biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3491-MONOMER.
UniPathwayiUPA00077; UER00149.

Protein family/group databases

MEROPSiC26.955.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase component 2 (EC:2.6.1.85)
Short name:
ADC synthase
Short name:
ADCS
Alternative name(s):
4-amino-4-deoxychorismate synthase component 2
Aminodeoxychorismate synthase, glutamine amidotransferase component
Gene namesi
Name:pabA
Ordered Locus Names:STM3469
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Aminodeoxychorismate synthase component 2PRO_0000056851Add
BLAST

Proteomic databases

PaxDbiP06193.
PRIDEiP06193.

Interactioni

Subunit structurei

Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) (By similarity).By similarity

Protein-protein interaction databases

STRINGi99287.STM3469.

Structurei

3D structure databases

ProteinModelPortaliP06193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 187187Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105DDQ. Bacteria.
COG0512. LUCA.
HOGENOMiHOG000025029.
KOiK01664.
OMAiPCSPDEA.
PhylomeDBiP06193.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLIDNYDS FTWNLYQYFC ELGAEVQVRR NDALTLAHID ALNPQKIVIS
60 70 80 90 100
PGPCTPNDAG ISLAVIRHYA GRIPMLGVCL GHQAMAQAFG ASVVRAAKVM
110 120 130 140 150
HGKTSPVTHN GQGVFRGLPS PLTVTRYHSL IVDPATLPEC FEITAWSETQ
160 170 180
EIMGIRHREW DLEGVQFHPE SILSEQGHAL LKNFLRR
Length:187
Mass (Da):20,801
Last modified:January 1, 1988 - v1
Checksum:iAB283D23FA543846
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02603 Genomic DNA. Translation: CAA26450.1.
M32355 Genomic DNA. Translation: AAA27177.1.
AE006468 Genomic DNA. Translation: AAL22331.1.
PIRiS09636.
RefSeqiNP_462372.1. NC_003197.1.
WP_000601880.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22331; AAL22331; STM3469.
GeneIDi1254992.
KEGGistm:STM3469.
PATRICi32385737. VBISalEnt20916_3666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02603 Genomic DNA. Translation: CAA26450.1.
M32355 Genomic DNA. Translation: AAA27177.1.
AE006468 Genomic DNA. Translation: AAL22331.1.
PIRiS09636.
RefSeqiNP_462372.1. NC_003197.1.
WP_000601880.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP06193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3469.

Protein family/group databases

MEROPSiC26.955.

Proteomic databases

PaxDbiP06193.
PRIDEiP06193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22331; AAL22331; STM3469.
GeneIDi1254992.
KEGGistm:STM3469.
PATRICi32385737. VBISalEnt20916_3666.

Phylogenomic databases

eggNOGiENOG4105DDQ. Bacteria.
COG0512. LUCA.
HOGENOMiHOG000025029.
KOiK01664.
OMAiPCSPDEA.
PhylomeDBiP06193.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00149.
BioCyciSENT99287:GCTI-3491-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPABA_SALTY
AccessioniPrimary (citable) accession number: P06193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.