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Protein

Aminodeoxychorismate synthase component 2

Gene

pabA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB (By similarity).By similarity

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Aminodeoxychorismate synthase component 1 (pabB), Aminodeoxychorismate synthase component 2 (pabA)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79PROSITE-ProRule annotation1
Active sitei168PROSITE-ProRule annotation1
Active sitei170PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3504-MONOMER
UniPathwayiUPA00077; UER00149

Protein family/group databases

MEROPSiC26.955

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase component 2 (EC:2.6.1.85)
Short name:
ADC synthase
Short name:
ADCS
Alternative name(s):
4-amino-4-deoxychorismate synthase component 2
Aminodeoxychorismate synthase, glutamine amidotransferase component
Gene namesi
Name:pabA
Ordered Locus Names:STM3469
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568511 – 187Aminodeoxychorismate synthase component 2Add BLAST187

Proteomic databases

PaxDbiP06193
PRIDEiP06193

Interactioni

Subunit structurei

Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) (By similarity).By similarity

Protein-protein interaction databases

STRINGi99287.STM3469

Structurei

3D structure databases

ProteinModelPortaliP06193
SMRiP06193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 187Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST187

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105DDQ Bacteria
COG0512 LUCA
HOGENOMiHOG000025029
KOiK01664
OMAiAPELMHG
PhylomeDBiP06193

Family and domain databases

Gene3Di3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR006221 TrpG/PapA_dom
PfamiView protein in Pfam
PF00117 GATase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR00566 trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P06193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLIDNYDS FTWNLYQYFC ELGAEVQVRR NDALTLAHID ALNPQKIVIS
60 70 80 90 100
PGPCTPNDAG ISLAVIRHYA GRIPMLGVCL GHQAMAQAFG ASVVRAAKVM
110 120 130 140 150
HGKTSPVTHN GQGVFRGLPS PLTVTRYHSL IVDPATLPEC FEITAWSETQ
160 170 180
EIMGIRHREW DLEGVQFHPE SILSEQGHAL LKNFLRR
Length:187
Mass (Da):20,801
Last modified:January 1, 1988 - v1
Checksum:iAB283D23FA543846
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02603 Genomic DNA Translation: CAA26450.1
M32355 Genomic DNA Translation: AAA27177.1
AE006468 Genomic DNA Translation: AAL22331.1
PIRiS09636
RefSeqiNP_462372.1, NC_003197.2
WP_000601880.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22331; AAL22331; STM3469
GeneIDi1254992
KEGGistm:STM3469
PATRICifig|99287.12.peg.3666

Similar proteinsi

Entry informationi

Entry nameiPABA_SALTY
AccessioniPrimary (citable) accession number: P06193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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