P06193 (PABA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Para-aminobenzoate synthase glutamine amidotransferase component II
EC=2.6.1.85

Alternative name(s):
ADC synthase

Gene names

Name:	pabA
Ordered Locus Names:	STM3469

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Para-aminobenzoate synthase glutamine amidotransferase component II		PRO_0000056851
Regions
	Domain	1 – 187	187	Glutamine amidotransferase type-1
Sites
	Active site	79	1	By similarity
	Active site	168	1	By similarity
	Active site	170	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06193 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: AB283D23FA543846	FASTA	187	20,801
	10 20 30 40 50 60 MILLIDNYDS FTWNLYQYFC ELGAEVQVRR NDALTLAHID ALNPQKIVIS PGPCTPNDAG 70 80 90 100 110 120 ISLAVIRHYA GRIPMLGVCL GHQAMAQAFG ASVVRAAKVM HGKTSPVTHN GQGVFRGLPS 130 140 150 160 170 180 PLTVTRYHSL IVDPATLPEC FEITAWSETQ EIMGIRHREW DLEGVQFHPE SILSEQGHAL LKNFLRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of glutamine amidotransferase genes. Nucleotide sequences of the pabA genes from Salmonella typhimurium, Klebsiella aerogenes and Serratia marcescens." Kaplan J.B., Merkel W.K., Nichols B.P. J. Mol. Biol. 183:327-340(1985) [PubMed: 3894673] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Chromosomal organization and expression of Escherichia coli pabA." Tran P.V., Bannor T.A., Doktor S.Z., Nichols B.P. J. Bacteriol. 172:397-410(1990) [PubMed: 2403545] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02603 Genomic DNA. Translation: CAA26450.1. M32355 Genomic DNA. Translation: AAA27177.1. AE006468 Genomic DNA. Translation: AAL22331.1.
PIR	S09636.
RefSeq	NP_462372.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P06193.
ModBase	Search...
Proteomic databases
PRIDE	P06193.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1254992.
GenomeReviews	Gene locus STM3469 in contig AE006468_GR.
KEGG	stm:STM3469.
NMPDR	fig|99287.1.peg.3349.
PATRIC	32385737. VBISalEnt20916_3666.
Phylogenomic databases
HOGENOM	HBG292341.
OMA	SVDEIMG.
ProtClustDB	PRK08007.
Enzyme and pathway databases
BioCyc	STYP99287:STM3469-MONOMER.
Family and domain databases
InterPro	IPR017926. GATASE_1. IPR006221. TrpG_papA. [Graphical view]
KO	K01664.
Pfam	PF00117. GATase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00566. TrpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABA_SALTY

Accession

Primary (citable) accession number: P06193

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program