P06190 (ARAD_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-ribulose-5-phosphate 4-epimerase
EC=5.1.3.4

Alternative name(s):
Phosphoribulose isomerase

Gene names

Name:	araD
Ordered Locus Names:	STM0101

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-ribulose 5-phosphate = D-xylulose 5-phosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily.
Sequence caution	The sequence AAA27025.1 differs from that shown. Reason: Frameshift at position 202.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-arabinose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	L-ribulose-phosphate 4-epimerase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	L-ribulose-5-phosphate 4-epimerase		PRO_0000162920
Sites
	Metal binding	95	1	Zinc By similarity
	Metal binding	97	1	Zinc By similarity
	Metal binding	171	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06190 [UniParc]. Last modified January 23, 2002. Version 3. Checksum: DA473505739284F9	FASTA	231	25,531
	10 20 30 40 50 60 MLEDLKRQVL EANLALPKHN LVTLTWGNVS AVDRERGVLV IKPSGVDYSV MTADDMVVVS 70 80 90 100 110 120 LESGEVVEGH KKPSSDTPTH RLLYQAFPTI GGIVHTHSRH ATIWAQAGQP IPATGTTHAD 130 140 150 160 170 180 YFYGTIPCTR KMTEAEINGE YEWETGNVIV ETFEKQGIDA AQMPGVLVHS HGPFAWGKNA 190 200 210 220 230 EDAVHNAIVL EEVAYMGIFC RQLAPQLPDM QQSLLDKHYL RKHGAKAYYG Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The araBAD operon of Salmonella typhimurium LT2. III. Nucleotide sequence of araD and its flanking regions, and primary structure of its product, L-ribulose-5-phosphate 4-epimerase." Lin H.-C., Lei S.-P., Studnicka G., Wilcox G. Gene 34:129-134(1985) [PubMed: 3891514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11047 Genomic DNA. Translation: AAA27025.1. Frameshift. AE006468 Genomic DNA. Translation: AAL19065.1.
PIR	ISEB4T. A24986.
RefSeq	NP_459106.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P06190.
SMR	P06190. Positions 1-223.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1251619.
GenomeReviews	Gene locus STM0101 in contig AE006468_GR.
KEGG	stm:STM0101.
NMPDR	fig|99287.1.peg.99.
PATRIC	32378469. VBISalEnt20916_0104.
Phylogenomic databases
HOGENOM	HBG541069.
OMA	SIPCTRK.
ProtClustDB	PRK08193.
Enzyme and pathway databases
BioCyc	STYP99287:STM0101-MONOMER.
Family and domain databases
InterPro	IPR001303. Aldolase_II/adducin_N. IPR004661. AraD. [Graphical view]
Gene3D	G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
KO	K01786.
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
TIGRFAMs	TIGR00760. AraD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAD_SALTY

Accession

Primary (citable) accession number: P06190

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 23, 2002
Last modified:	January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program