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Protein

Cytochrome c heme lyase

Gene

CYC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

  • holocytochrome-c synthase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cytochrome c-heme linkage Source: SGD

Keywordsi

Molecular functionLyase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YAL039C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome-c synthase
Gene namesi
Name:CYC3
Ordered Locus Names:YAL039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL039C.
SGDiS000000037. CYC3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217181 – 269Cytochrome c heme lyaseAdd BLAST269

Proteomic databases

MaxQBiP06182.
PRIDEiP06182.

Interactioni

Protein-protein interaction databases

BioGridi31726. 98 interactors.
IntActiP06182. 13 interactors.
MINTiMINT-4475754.
STRINGi4932.YAL039C.

Structurei

3D structure databases

ProteinModelPortaliP06182.
SMRiP06182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 30HRM 16
Repeati41 – 46HRM 26

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
InParanoidiP06182.
KOiK01764.
OMAiIDYYSAP.
OrthoDBiEOG092C4FRK.

Family and domain databases

InterProiView protein in InterPro
IPR000511. Cyt_C/C1_haem_lyase.
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiView protein in Pfam
PF01265. Cyto_heme_lyase. 1 hit.
PROSITEiView protein in PROSITE
PS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P06182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND
60 70 80 90 100
RINPLNNMPE LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM
110 120 130 140 150
YNAMVRKGKI GGSGEVAEDA VESMVQVHNF LNEGCWQEVL EWEKPHTDES
160 170 180 190 200
HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF PSHFSQELPF DRHDWIVLRG
210 220 230 240 250
ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA LDSLDNAKDR
260
MTRFLDRMIS GPSSSSSAP
Length:269
Mass (Da):30,081
Last modified:January 1, 1988 - v1
Checksum:iA672A48BBFD848AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04776 Genomic DNA. Translation: CAA28470.1.
U12980 Genomic DNA. Translation: AAC04992.1.
BK006935 Genomic DNA. Translation: DAA06947.1.
PIRiA26162.
RefSeqiNP_009361.1. NM_001178184.1.

Genome annotation databases

EnsemblFungiiYAL039C; YAL039C; YAL039C.
GeneIDi851192.
KEGGisce:YAL039C.

Similar proteinsi

Entry informationi

Entry nameiCCHL_YEAST
AccessioniPrimary (citable) accession number: P06182
Secondary accession number(s): D6VPH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: August 30, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names