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Protein

Cytochrome c heme lyase

Gene

CYC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

  • holocytochrome-c synthase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cytochrome c-heme linkage Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YAL039C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome-c synthase
Gene namesi
Name:CYC3
Ordered Locus Names:YAL039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL039C.
SGDiS000000037. CYC3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial intermembrane space Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c heme lyasePRO_0000121718Add
BLAST

Proteomic databases

MaxQBiP06182.

Interactioni

Protein-protein interaction databases

BioGridi31726. 25 interactions.
IntActiP06182. 13 interactions.
MINTiMINT-4475754.

Structurei

3D structure databases

ProteinModelPortaliP06182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 306HRM 1
Repeati41 – 466HRM 2

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
InParanoidiP06182.
KOiK01764.
OMAiMKWNIGS.
OrthoDBiEOG092C4FRK.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND
60 70 80 90 100
RINPLNNMPE LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM
110 120 130 140 150
YNAMVRKGKI GGSGEVAEDA VESMVQVHNF LNEGCWQEVL EWEKPHTDES
160 170 180 190 200
HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF PSHFSQELPF DRHDWIVLRG
210 220 230 240 250
ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA LDSLDNAKDR
260
MTRFLDRMIS GPSSSSSAP
Length:269
Mass (Da):30,081
Last modified:January 1, 1988 - v1
Checksum:iA672A48BBFD848AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04776 Genomic DNA. Translation: CAA28470.1.
U12980 Genomic DNA. Translation: AAC04992.1.
BK006935 Genomic DNA. Translation: DAA06947.1.
PIRiA26162.
RefSeqiNP_009361.1. NM_001178184.1.

Genome annotation databases

EnsemblFungiiYAL039C; YAL039C; YAL039C.
GeneIDi851192.
KEGGisce:YAL039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04776 Genomic DNA. Translation: CAA28470.1.
U12980 Genomic DNA. Translation: AAC04992.1.
BK006935 Genomic DNA. Translation: DAA06947.1.
PIRiA26162.
RefSeqiNP_009361.1. NM_001178184.1.

3D structure databases

ProteinModelPortaliP06182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31726. 25 interactions.
IntActiP06182. 13 interactions.
MINTiMINT-4475754.

Proteomic databases

MaxQBiP06182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL039C; YAL039C; YAL039C.
GeneIDi851192.
KEGGisce:YAL039C.

Organism-specific databases

EuPathDBiFungiDB:YAL039C.
SGDiS000000037. CYC3.

Phylogenomic databases

GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
InParanoidiP06182.
KOiK01764.
OMAiMKWNIGS.
OrthoDBiEOG092C4FRK.

Enzyme and pathway databases

BioCyciYEAST:YAL039C-MONOMER.

Miscellaneous databases

PROiP06182.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCHL_YEAST
AccessioniPrimary (citable) accession number: P06182
Secondary accession number(s): D6VPH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.