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Protein

Histone-binding protein N1/N2

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

GO - Molecular functioni

  • importin-alpha family protein binding Source: CAFA

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-binding protein N1/N2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980259. nasp.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000839712 – 590Histone-binding protein N1/N2Add BLAST589

Interactioni

GO - Molecular functioni

  • importin-alpha family protein binding Source: CAFA

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PJNX-ray2.50A532-559[»]
SMRiP06180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 69TPR 1Add BLAST34
Repeati357 – 390TPR 2Add BLAST34
Repeati399 – 432TPR 3Add BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 537Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 119Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi290 – 326Asp/Glu-rich (acidic)Add BLAST37

Sequence similaritiesi

Belongs to the NASP family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOVERGENiHBG002186.
KOiK11291.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR019544. Tetratricopeptide_SHNi-TPR_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF10516. SHNi-TPR. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEETAALST EKTEDTSTAP STSAEKADGI DIDTEAKRLM GAGQKHLVMK
60 70 80 90 100
DVRSAVNLFQ EASSLLAKQY GETADECAEA FYSYGMSLLE LARLENGVLG
110 120 130 140 150
NALEGMPEDD EEEAEKEEDP NIPSADNLDE KEREQLREQV YDAMAEDQRA
160 170 180 190 200
PDDTSESEAK GKPEGDSKDK EADEKMKNGQ KETEKVTDDL KIDSASRDVP
210 220 230 240 250
MDKSGKGEPP ESKDAETLVE QKESKPETLK EKSIETKEKD LSKEKTDAKE
260 270 280 290 300
TANQSPDSTE VAEEKMDSEA SESKESTSIP PTENEANKPD DPEKMEEEEE
310 320 330 340 350
GEDSEENEDG TEENEGTEEK ETEEEDVGNL QLAWEMLDLC KTIFKRQQSK
360 370 380 390 400
EAQLKAAQAH QKLGEVCIES ENYSQAVEDF LACLNIQKEH LEEHDRLLAE
410 420 430 440 450
THYHLGLAYQ YSSKHEEAIS HFTQSIGVIE KRMDVLTKQL EASVGELVDE
460 470 480 490 500
VKKEMDELKD LLPDIKEKIE DSKEAQKNAT VTEKALKETL VGGSSGFSKE
510 520 530 540 550
NGSTSSSSAV EKSGDSTVPV TNCVSDISHL VRKKRKTEEE SPLKDKDAKK
560 570 580 590
SKQEPVANGA GNGDAVVPTN EEAEKAEEAS METATVESTA
Length:590
Mass (Da):65,029
Last modified:January 23, 2007 - v3
Checksum:iC4F072577665E180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04712 mRNA. Translation: CAA28419.1.
PIRiA25680.
RefSeqiNP_001081537.1. NM_001088068.1.
UniGeneiXl.48795.

Genome annotation databases

GeneIDi397901.
KEGGixla:397901.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHIBN_XENLA
AccessioniPrimary (citable) accession number: P06180
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families