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P06180

- HIBN_XENLA

UniProt

P06180 - HIBN_XENLA

Protein

Histone-binding protein N1/N2

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-binding protein N1/N2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-980259. nasp.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 590589Histone-binding protein N1/N2PRO_0000083971Add
    BLAST

    Proteomic databases

    PRIDEiP06180.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PJNX-ray2.50A532-559[»]
    DisProtiDP00213.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP06180.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati36 – 6934TPR 1Add
    BLAST
    Repeati357 – 39034TPR 2Add
    BLAST
    Repeati399 – 43234TPR 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi531 – 5377Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi108 – 11912Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi290 – 32637Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the NASP family.Curated
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    HOVERGENiHBG002186.
    KOiK11291.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR019544. Tetratricopeptide_SHNi-TPR_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF10516. SHNi-TPR. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEETAALST EKTEDTSTAP STSAEKADGI DIDTEAKRLM GAGQKHLVMK    50
    DVRSAVNLFQ EASSLLAKQY GETADECAEA FYSYGMSLLE LARLENGVLG 100
    NALEGMPEDD EEEAEKEEDP NIPSADNLDE KEREQLREQV YDAMAEDQRA 150
    PDDTSESEAK GKPEGDSKDK EADEKMKNGQ KETEKVTDDL KIDSASRDVP 200
    MDKSGKGEPP ESKDAETLVE QKESKPETLK EKSIETKEKD LSKEKTDAKE 250
    TANQSPDSTE VAEEKMDSEA SESKESTSIP PTENEANKPD DPEKMEEEEE 300
    GEDSEENEDG TEENEGTEEK ETEEEDVGNL QLAWEMLDLC KTIFKRQQSK 350
    EAQLKAAQAH QKLGEVCIES ENYSQAVEDF LACLNIQKEH LEEHDRLLAE 400
    THYHLGLAYQ YSSKHEEAIS HFTQSIGVIE KRMDVLTKQL EASVGELVDE 450
    VKKEMDELKD LLPDIKEKIE DSKEAQKNAT VTEKALKETL VGGSSGFSKE 500
    NGSTSSSSAV EKSGDSTVPV TNCVSDISHL VRKKRKTEEE SPLKDKDAKK 550
    SKQEPVANGA GNGDAVVPTN EEAEKAEEAS METATVESTA 590
    Length:590
    Mass (Da):65,029
    Last modified:January 23, 2007 - v3
    Checksum:iC4F072577665E180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04712 mRNA. Translation: CAA28419.1.
    PIRiA25680.
    RefSeqiNP_001081537.1. NM_001088068.1.
    UniGeneiXl.48795.

    Genome annotation databases

    GeneIDi397901.
    KEGGixla:397901.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04712 mRNA. Translation: CAA28419.1 .
    PIRi A25680.
    RefSeqi NP_001081537.1. NM_001088068.1.
    UniGenei Xl.48795.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PJN X-ray 2.50 A 532-559 [» ]
    DisProti DP00213.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P06180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397901.
    KEGGi xla:397901.

    Organism-specific databases

    CTDi 4678.
    Xenbasei XB-GENE-980259. nasp.

    Phylogenomic databases

    HOVERGENi HBG002186.
    KOi K11291.

    Miscellaneous databases

    EvolutionaryTracei P06180.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR019544. Tetratricopeptide_SHNi-TPR_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF10516. SHNi-TPR. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis."
      Kleinschmidt J.A., Dingwall C., Maier G., Franke W.W.
      EMBO J. 5:3547-3552(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Oocyte.

    Entry informationi

    Entry nameiHIBN_XENLA
    AccessioniPrimary (citable) accession number: P06180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3