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P06180 (HIBN_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-binding protein N1/N2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the NASP family.

Contains 3 TPR repeats.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
TPR repeat
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 590589Histone-binding protein N1/N2
PRO_0000083971

Regions

Repeat36 – 6934TPR 1
Repeat357 – 39034TPR 2
Repeat399 – 43234TPR 3
Motif531 – 5377Nuclear localization signal Potential
Compositional bias108 – 11912Asp/Glu-rich (acidic)
Compositional bias290 – 32637Asp/Glu-rich (acidic)

Sequences

Sequence LengthMass (Da)Tools
P06180 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C4F072577665E180

FASTA59065,029
        10         20         30         40         50         60 
MAEETAALST EKTEDTSTAP STSAEKADGI DIDTEAKRLM GAGQKHLVMK DVRSAVNLFQ 

        70         80         90        100        110        120 
EASSLLAKQY GETADECAEA FYSYGMSLLE LARLENGVLG NALEGMPEDD EEEAEKEEDP 

       130        140        150        160        170        180 
NIPSADNLDE KEREQLREQV YDAMAEDQRA PDDTSESEAK GKPEGDSKDK EADEKMKNGQ 

       190        200        210        220        230        240 
KETEKVTDDL KIDSASRDVP MDKSGKGEPP ESKDAETLVE QKESKPETLK EKSIETKEKD 

       250        260        270        280        290        300 
LSKEKTDAKE TANQSPDSTE VAEEKMDSEA SESKESTSIP PTENEANKPD DPEKMEEEEE 

       310        320        330        340        350        360 
GEDSEENEDG TEENEGTEEK ETEEEDVGNL QLAWEMLDLC KTIFKRQQSK EAQLKAAQAH 

       370        380        390        400        410        420 
QKLGEVCIES ENYSQAVEDF LACLNIQKEH LEEHDRLLAE THYHLGLAYQ YSSKHEEAIS 

       430        440        450        460        470        480 
HFTQSIGVIE KRMDVLTKQL EASVGELVDE VKKEMDELKD LLPDIKEKIE DSKEAQKNAT 

       490        500        510        520        530        540 
VTEKALKETL VGGSSGFSKE NGSTSSSSAV EKSGDSTVPV TNCVSDISHL VRKKRKTEEE 

       550        560        570        580        590 
SPLKDKDAKK SKQEPVANGA GNGDAVVPTN EEAEKAEEAS METATVESTA 

« Hide

References

[1]"Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis."
Kleinschmidt J.A., Dingwall C., Maier G., Franke W.W.
EMBO J. 5:3547-3552(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Oocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04712 mRNA. Translation: CAA28419.1.
PIRA25680.
RefSeqNP_001081537.1. NM_001088068.1.
UniGeneXl.48795.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PJNX-ray2.50A532-559[»]
DisProtDP00213.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP06180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397901.
KEGGxla:397901.

Organism-specific databases

CTD4678.
XenbaseXB-GENE-980259. nasp.

Phylogenomic databases

HOVERGENHBG002186.
KOK11291.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR019544. Tetratricopeptide_SHNi-TPR_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF10516. SHNi-TPR. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP06180.

Entry information

Entry nameHIBN_XENLA
AccessionPrimary (citable) accession number: P06180
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references