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P06180

- HIBN_XENLA

UniProt

P06180 - HIBN_XENLA

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Protein

Histone-binding protein N1/N2

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-binding protein N1/N2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980259. nasp.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 590589Histone-binding protein N1/N2PRO_0000083971Add
BLAST

Proteomic databases

PRIDEiP06180.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PJNX-ray2.50A532-559[»]
DisProtiDP00213.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6934TPR 1Add
BLAST
Repeati357 – 39034TPR 2Add
BLAST
Repeati399 – 43234TPR 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi531 – 5377Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 11912Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi290 – 32637Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the NASP family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOVERGENiHBG002186.
KOiK11291.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019544. Tetratricopeptide_SHNi-TPR_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF10516. SHNi-TPR. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06180-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEETAALST EKTEDTSTAP STSAEKADGI DIDTEAKRLM GAGQKHLVMK
60 70 80 90 100
DVRSAVNLFQ EASSLLAKQY GETADECAEA FYSYGMSLLE LARLENGVLG
110 120 130 140 150
NALEGMPEDD EEEAEKEEDP NIPSADNLDE KEREQLREQV YDAMAEDQRA
160 170 180 190 200
PDDTSESEAK GKPEGDSKDK EADEKMKNGQ KETEKVTDDL KIDSASRDVP
210 220 230 240 250
MDKSGKGEPP ESKDAETLVE QKESKPETLK EKSIETKEKD LSKEKTDAKE
260 270 280 290 300
TANQSPDSTE VAEEKMDSEA SESKESTSIP PTENEANKPD DPEKMEEEEE
310 320 330 340 350
GEDSEENEDG TEENEGTEEK ETEEEDVGNL QLAWEMLDLC KTIFKRQQSK
360 370 380 390 400
EAQLKAAQAH QKLGEVCIES ENYSQAVEDF LACLNIQKEH LEEHDRLLAE
410 420 430 440 450
THYHLGLAYQ YSSKHEEAIS HFTQSIGVIE KRMDVLTKQL EASVGELVDE
460 470 480 490 500
VKKEMDELKD LLPDIKEKIE DSKEAQKNAT VTEKALKETL VGGSSGFSKE
510 520 530 540 550
NGSTSSSSAV EKSGDSTVPV TNCVSDISHL VRKKRKTEEE SPLKDKDAKK
560 570 580 590
SKQEPVANGA GNGDAVVPTN EEAEKAEEAS METATVESTA
Length:590
Mass (Da):65,029
Last modified:January 23, 2007 - v3
Checksum:iC4F072577665E180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04712 mRNA. Translation: CAA28419.1.
PIRiA25680.
RefSeqiNP_001081537.1. NM_001088068.1.
UniGeneiXl.48795.

Genome annotation databases

GeneIDi397901.
KEGGixla:397901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04712 mRNA. Translation: CAA28419.1 .
PIRi A25680.
RefSeqi NP_001081537.1. NM_001088068.1.
UniGenei Xl.48795.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PJN X-ray 2.50 A 532-559 [» ]
DisProti DP00213.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P06180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397901.
KEGGi xla:397901.

Organism-specific databases

CTDi 4678.
Xenbasei XB-GENE-980259. nasp.

Phylogenomic databases

HOVERGENi HBG002186.
KOi K11291.

Miscellaneous databases

EvolutionaryTracei P06180.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR019544. Tetratricopeptide_SHNi-TPR_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF10516. SHNi-TPR. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis."
    Kleinschmidt J.A., Dingwall C., Maier G., Franke W.W.
    EMBO J. 5:3547-3552(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Oocyte.

Entry informationi

Entry nameiHIBN_XENLA
AccessioniPrimary (citable) accession number: P06180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3