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Protein

Flagellin

Gene

fliC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451534. TLR5 cascade.
R-GGA-977240. MyD88 cascade initiated on plasma membrane.
R-HSA-844623. The IPAF inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellin
Alternative name(s):
Phase 1-I flagellin
Gene namesi
Name:fliC
Synonyms:flaF, hag
Ordered Locus Names:STM1959
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001825782 – 495FlagellinAdd BLAST494

Proteomic databases

PaxDbiP06179.
PRIDEiP06179.

Expressioni

Inductioni

Inhibited in nutrient-poor medium (at protein level).1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliSP266096EBI-2011501,EBI-2011519

Protein-protein interaction databases

DIPiDIP-43768N.
IntActiP06179. 1 interactor.
MINTiMINT-2831235.
STRINGi99287.STM1959.

Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi59 – 99Combined sources41
Helixi106 – 129Combined sources24
Turni137 – 139Combined sources3
Beta strandi142 – 147Combined sources6
Beta strandi149 – 151Combined sources3
Beta strandi155 – 160Combined sources6
Turni165 – 169Combined sources5
Beta strandi180 – 185Combined sources6
Beta strandi190 – 197Combined sources8
Helixi200 – 202Combined sources3
Turni204 – 206Combined sources3
Helixi208 – 210Combined sources3
Beta strandi212 – 217Combined sources6
Beta strandi219 – 223Combined sources5
Turni225 – 227Combined sources3
Beta strandi230 – 237Combined sources8
Beta strandi244 – 250Combined sources7
Turni252 – 254Combined sources3
Beta strandi256 – 260Combined sources5
Beta strandi277 – 285Combined sources9
Helixi286 – 288Combined sources3
Helixi290 – 298Combined sources9
Beta strandi305 – 313Combined sources9
Beta strandi319 – 328Combined sources10
Beta strandi331 – 337Combined sources7
Beta strandi343 – 345Combined sources3
Beta strandi353 – 356Combined sources4
Beta strandi361 – 366Combined sources6
Beta strandi371 – 376Combined sources6
Beta strandi379 – 382Combined sources4
Helixi383 – 386Combined sources4
Turni391 – 393Combined sources3
Helixi408 – 448Combined sources41

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IO1X-ray2.00A54-451[»]
1P95model-A57-451[»]
1UCUelectron microscopy4.00A2-495[»]
3A5Xelectron microscopy4.00A2-495[»]
DisProtiDP00026.
ProteinModelPortaliP06179.
SMRiP06179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06179.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial flagellin family.Curated

Phylogenomic databases

eggNOGiENOG4105I03. Bacteria.
COG1344. LUCA.
HOGENOMiHOG000255144.
KOiK02406.
OMAiAMVVMDM.
PhylomeDBiP06179.

Family and domain databases

Gene3Di1.20.1330.10. 2 hits.
InterProiIPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view]
PfamiPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSiPR00207. FLAGELLIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVINTNSL SLLTQNNLNK SQSALGTAIE RLSSGLRINS AKDDAAGQAI
60 70 80 90 100
ANRFTANIKG LTQASRNAND GISIAQTTEG ALNEINNNLQ RVRELAVQSA
110 120 130 140 150
NSTNSQSDLD SIQAEITQRL NEIDRVSGQT QFNGVKVLAQ DNTLTIQVGA
160 170 180 190 200
NDGETIDIDL KQINSQTLGL DTLNVQQKYK VSDTAATVTG YADTTIALDN
210 220 230 240 250
STFKASATGL GGTDQKIDGD LKFDDTTGKY YAKVTVTGGT GKDGYYEVSV
260 270 280 290 300
DKTNGEVTLA GGATSPLTGG LPATATEDVK NVQVANADLT EAKAALTAAG
310 320 330 340 350
VTGTASVVKM SYTDNNGKTI DGGLAVKVGD DYYSATQNKD GSISINTTKY
360 370 380 390 400
TADDGTSKTA LNKLGGADGK TEVVSIGGKT YAASKAEGHN FKAQPDLAEA
410 420 430 440 450
AATTTENPLQ KIDAALAQVD TLRSDLGAVQ NRFNSAITNL GNTVNNLTSA
460 470 480 490
RSRIEDSDYA TEVSNMSRAQ ILQQAGTSVL AQANQVPQNV LSLLR
Length:495
Mass (Da):51,612
Last modified:January 23, 2007 - v4
Checksum:i4BD7849FA3B936BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127S → N in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti133N → S in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti215Q → E in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti261 – 273GGATS…GGLPA → AVTPATVT in AAA27072 (PubMed:2999134).CuratedAdd BLAST13
Sequence conflicti277 – 284EDVKNVQV → ALSGKMYS in AAA27072 (PubMed:2999134).Curated8
Sequence conflicti287 – 291ADLTE → PDSDI in AAA27072 (PubMed:2999134).Curated5
Sequence conflicti338N → D in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti346N → D in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti354D → N in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti375 – 377SIG → TID in AAA27072 (PubMed:2999134).Curated3
Sequence conflicti382A → N in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti387E → A in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti390N → D in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti394 – 396QPD → EPE in AAA27072 (PubMed:2999134).Curated3
Sequence conflicti400A → Q in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti403T → K in AAA27072 (PubMed:2999134).Curated1
Sequence conflicti448T → S in AAA27072 (PubMed:2999134).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11332 Genomic DNA. Translation: AAA27072.1.
D13689 Genomic DNA. Translation: BAA02846.1.
AE006468 Genomic DNA. Translation: AAL20871.1.
X51740 Genomic DNA. Translation: CAA36029.1.
J01801 Genomic DNA. Translation: AAA27074.1.
M33808 Genomic DNA. Translation: AAA27080.1.
Z54217 Genomic DNA. Translation: CAA90950.1.
PIRiA24262.
S16121.
RefSeqiNP_460912.1. NC_003197.1.
WP_000079805.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20871; AAL20871; STM1959.
GeneIDi1253480.
KEGGistm:STM1959.
PATRICi32382477. VBISalEnt20916_2074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11332 Genomic DNA. Translation: AAA27072.1.
D13689 Genomic DNA. Translation: BAA02846.1.
AE006468 Genomic DNA. Translation: AAL20871.1.
X51740 Genomic DNA. Translation: CAA36029.1.
J01801 Genomic DNA. Translation: AAA27074.1.
M33808 Genomic DNA. Translation: AAA27080.1.
Z54217 Genomic DNA. Translation: CAA90950.1.
PIRiA24262.
S16121.
RefSeqiNP_460912.1. NC_003197.1.
WP_000079805.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IO1X-ray2.00A54-451[»]
1P95model-A57-451[»]
1UCUelectron microscopy4.00A2-495[»]
3A5Xelectron microscopy4.00A2-495[»]
DisProtiDP00026.
ProteinModelPortaliP06179.
SMRiP06179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-43768N.
IntActiP06179. 1 interactor.
MINTiMINT-2831235.
STRINGi99287.STM1959.

Proteomic databases

PaxDbiP06179.
PRIDEiP06179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20871; AAL20871; STM1959.
GeneIDi1253480.
KEGGistm:STM1959.
PATRICi32382477. VBISalEnt20916_2074.

Phylogenomic databases

eggNOGiENOG4105I03. Bacteria.
COG1344. LUCA.
HOGENOMiHOG000255144.
KOiK02406.
OMAiAMVVMDM.
PhylomeDBiP06179.

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451534. TLR5 cascade.
R-GGA-977240. MyD88 cascade initiated on plasma membrane.
R-HSA-844623. The IPAF inflammasome.

Miscellaneous databases

EvolutionaryTraceiP06179.

Family and domain databases

Gene3Di1.20.1330.10. 2 hits.
InterProiIPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view]
PfamiPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSiPR00207. FLAGELLIN.
ProtoNetiSearch...

Entry informationi

Entry nameiFLIC_SALTY
AccessioniPrimary (citable) accession number: P06179
Secondary accession number(s): P97160, Q02871, Q56088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes, fliC and fljB.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.