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P06174

- HEM4_YEAST

UniProt

P06174 - HEM4_YEAST

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Protein
Uroporphyrinogen-III synthase
Gene
HEM4, ORF1, YOR278W, O5463
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: SGD

GO - Biological processi

  1. heme biosynthetic process Source: SGD
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YOR278W-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROIIIS
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:HEM4
Synonyms:ORF1
Ordered Locus Names:YOR278W
ORF Names:O5463
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR278w.
SGDiS000005804. HEM4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Uroporphyrinogen-III synthase
PRO_0000135254Add
BLAST

Proteomic databases

MaxQBiP06174.
PaxDbiP06174.

Expressioni

Gene expression databases

GenevestigatoriP06174.

Interactioni

Protein-protein interaction databases

BioGridi34666. 3 interactions.
IntActiP06174. 2 interactions.
STRINGi4932.YOR278W.

Structurei

3D structure databases

ProteinModelPortaliP06174.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
GeneTreeiENSGT00390000009853.
HOGENOMiHOG000216635.
KOiK01719.
OMAiTGVMESF.
OrthoDBiEOG7J44HQ.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P06174-1 [UniParc]FASTAAdd to Basket

« Hide

MSSRKKVRVL LLKNKTVPID KYELECRSKA FEPIFVPLIK HTHVIQDFRN    50
VLNTIPNYLN TINYIIITSQ RTVESLNEAI IPTLTSEQKA ALLSKTVYTV 100
GPATANFIRR SGFINVKGGE DAGNGSILAD IIIDDLSTDI KACPPSELLF 150
LVGEIRRDII PKKLHSKGIK VREVVTYKTE ELSDGFKRFI HAMKECDEDE 200
VFSDWVVVFS PQGTKEITQY LGDSNRLPGS HLRVASIGPT TKKYLDDNDV 250
TSDVVSPKPD PKSLLDAIEL YQRHK 275
Length:275
Mass (Da):30,912
Last modified:October 1, 1996 - v2
Checksum:iCDC857C8CFB4E1A7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 27545HLRVA…YQRHK → IYGLRHRTYH in CAA28399. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04694 Genomic DNA. Translation: CAA28399.1.
X89633 Genomic DNA. Translation: CAA61783.1.
Z75186 Genomic DNA. Translation: CAA99504.1.
BK006948 Genomic DNA. Translation: DAA11043.1.
PIRiS67180. RGBY7K.
RefSeqiNP_014921.1. NM_001183697.1.

Genome annotation databases

EnsemblFungiiYOR278W; YOR278W; YOR278W.
GeneIDi854452.
KEGGisce:YOR278W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04694 Genomic DNA. Translation: CAA28399.1 .
X89633 Genomic DNA. Translation: CAA61783.1 .
Z75186 Genomic DNA. Translation: CAA99504.1 .
BK006948 Genomic DNA. Translation: DAA11043.1 .
PIRi S67180. RGBY7K.
RefSeqi NP_014921.1. NM_001183697.1.

3D structure databases

ProteinModelPortali P06174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34666. 3 interactions.
IntActi P06174. 2 interactions.
STRINGi 4932.YOR278W.

Proteomic databases

MaxQBi P06174.
PaxDbi P06174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR278W ; YOR278W ; YOR278W .
GeneIDi 854452.
KEGGi sce:YOR278W.

Organism-specific databases

CYGDi YOR278w.
SGDi S000005804. HEM4.

Phylogenomic databases

eggNOGi COG1587.
GeneTreei ENSGT00390000009853.
HOGENOMi HOG000216635.
KOi K01719.
OMAi TGVMESF.
OrthoDBi EOG7J44HQ.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci YEAST:YOR278W-MONOMER.

Miscellaneous databases

NextBioi 976715.
PROi P06174.

Gene expression databases

Genevestigatori P06174.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a nuclear yeast gene involved in the mitochondrial import of cytoplasmically synthesized precursor proteins."
    Langgut W., Entrup R., Schweizer E.
    Curr. Genet. 11:177-184(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae."
    Cheret G., Bernardi A., Sor F.J.
    Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae."
    Amillet J.-M., Labbe-Bois R.
    Yeast 11:419-424(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHEM4_YEAST
AccessioniPrimary (citable) accession number: P06174
Secondary accession number(s): D6W2X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1360 molecules/cell in log phase SD medium.

Caution

Was originally (1 Publication) thought to be involved in mitochondrial import.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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