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P06167

- HN_PI3B

UniProt

P06167 - HN_PI3B

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Bovine parainfluenza 3 virus (BPIV-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiBovine parainfluenza 3 virus (BPIV-3)
    Taxonomic identifieri11215 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Hemagglutinin-neuraminidasePRO_0000142624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi308 – 3081N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP06167.
    SMRiP06167. Positions 142-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini52 – 572521Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P06167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYWKHTNST KDTNNELGTT RDRHSSKATN IIMYIFWTTT STILSVIFIM    50
    ILINLIQENN HNKLMLQEIR KEFAAIDTKI QKTSDDIGTS IQSGINTRLL 100
    TIQSHVQNYI PLSLTQQMSD LRKFINDLTT KREHQEVPIQ RMTHDSGIEP 150
    LNPDKFWRCT SGNPSLTSSP KIRLIPGPGL LATSTTVNGC IRLPSLAINN 200
    LIYAYTSNLI TQGCQDIGKS YQVLQIGIIT INSDLVPDLN PRVTHTFNID 250
    DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASTGIEDIVL DIVTSNGLII 300
    TTRFTNNNIT FDKPYAALYP SVGPGIYYKD KVIFLGYGGL EHEENGDVIC 350
    NTTGCPGKTQ RDCNQASYSP WFSNRRMVNS IIVVDKGIDT TFSLRVWTIP 400
    MRQNYWGSEG RLLLLGDRIY IYTRSTSWHS KLQLGVIDIS DFNNIRINWT 450
    WHNVLSRPGN DECPWGHSCP DGCITGVYTD AYPLNPSGSI VSSVILDSQK 500
    SRENPIITYS TATNRVNELA IYNRTLPAAY TTTNCITHYD KGYCFHIVEI 550
    NHRSLNTFQP MLFKTEVPKN CS 572
    Length:572
    Mass (Da):64,590
    Last modified:January 1, 1988 - v1
    Checksum:iDDF84E90C4EC87B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00114 Genomic RNA. Translation: CAA68298.1.
    D84095 Genomic RNA. Translation: BAA12218.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00114 Genomic RNA. Translation: CAA68298.1 .
    D84095 Genomic RNA. Translation: BAA12218.1 .

    3D structure databases

    ProteinModelPortali P06167.
    SMRi P06167. Positions 142-572.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins."
      Suzu S., Sakai Y., Shioda T., Shibuta H.
      Nucleic Acids Res. 15:2945-2958(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: 910N.

    Entry informationi

    Entry nameiHN_PI3B
    AccessioniPrimary (citable) accession number: P06167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3