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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Bovine parainfluenza 3 virus (BPIV-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiBovine parainfluenza 3 virus (BPIV-3)
Taxonomic identifieri11215 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030IntravirionSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Topological domaini52 – 572521Virion surfaceSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Hemagglutinin-neuraminidasePRO_0000142624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi308 – 3081N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi351 – 3511N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi523 – 5231N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP06167.
SMRiP06167. Positions 142-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P06167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYWKHTNST KDTNNELGTT RDRHSSKATN IIMYIFWTTT STILSVIFIM
60 70 80 90 100
ILINLIQENN HNKLMLQEIR KEFAAIDTKI QKTSDDIGTS IQSGINTRLL
110 120 130 140 150
TIQSHVQNYI PLSLTQQMSD LRKFINDLTT KREHQEVPIQ RMTHDSGIEP
160 170 180 190 200
LNPDKFWRCT SGNPSLTSSP KIRLIPGPGL LATSTTVNGC IRLPSLAINN
210 220 230 240 250
LIYAYTSNLI TQGCQDIGKS YQVLQIGIIT INSDLVPDLN PRVTHTFNID
260 270 280 290 300
DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASTGIEDIVL DIVTSNGLII
310 320 330 340 350
TTRFTNNNIT FDKPYAALYP SVGPGIYYKD KVIFLGYGGL EHEENGDVIC
360 370 380 390 400
NTTGCPGKTQ RDCNQASYSP WFSNRRMVNS IIVVDKGIDT TFSLRVWTIP
410 420 430 440 450
MRQNYWGSEG RLLLLGDRIY IYTRSTSWHS KLQLGVIDIS DFNNIRINWT
460 470 480 490 500
WHNVLSRPGN DECPWGHSCP DGCITGVYTD AYPLNPSGSI VSSVILDSQK
510 520 530 540 550
SRENPIITYS TATNRVNELA IYNRTLPAAY TTTNCITHYD KGYCFHIVEI
560 570
NHRSLNTFQP MLFKTEVPKN CS
Length:572
Mass (Da):64,590
Last modified:January 1, 1988 - v1
Checksum:iDDF84E90C4EC87B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00114 Genomic RNA. Translation: CAA68298.1.
D84095 Genomic RNA. Translation: BAA12218.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00114 Genomic RNA. Translation: CAA68298.1.
D84095 Genomic RNA. Translation: BAA12218.1.

3D structure databases

ProteinModelPortaliP06167.
SMRiP06167. Positions 142-572.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins."
    Suzu S., Sakai Y., Shioda T., Shibuta H.
    Nucleic Acids Res. 15:2945-2958(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: 910N.

Entry informationi

Entry nameiHN_PI3B
AccessioniPrimary (citable) accession number: P06167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.