SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P06167

- HN_PI3B

UniProt

P06167 - HN_PI3B

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Bovine parainfluenza 3 virus (BPIV-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiBovine parainfluenza 3 virus (BPIV-3)
Taxonomic identifieri11215 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Intravirion Reviewed prediction
Add
BLAST
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Topological domaini52 – 572521Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Hemagglutinin-neuraminidase
PRO_0000142624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi308 – 3081N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi351 – 3511N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi523 – 5231N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP06167.
SMRiP06167. Positions 142-572.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P06167-1 [UniParc]FASTAAdd to Basket

« Hide

MEYWKHTNST KDTNNELGTT RDRHSSKATN IIMYIFWTTT STILSVIFIM    50
ILINLIQENN HNKLMLQEIR KEFAAIDTKI QKTSDDIGTS IQSGINTRLL 100
TIQSHVQNYI PLSLTQQMSD LRKFINDLTT KREHQEVPIQ RMTHDSGIEP 150
LNPDKFWRCT SGNPSLTSSP KIRLIPGPGL LATSTTVNGC IRLPSLAINN 200
LIYAYTSNLI TQGCQDIGKS YQVLQIGIIT INSDLVPDLN PRVTHTFNID 250
DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASTGIEDIVL DIVTSNGLII 300
TTRFTNNNIT FDKPYAALYP SVGPGIYYKD KVIFLGYGGL EHEENGDVIC 350
NTTGCPGKTQ RDCNQASYSP WFSNRRMVNS IIVVDKGIDT TFSLRVWTIP 400
MRQNYWGSEG RLLLLGDRIY IYTRSTSWHS KLQLGVIDIS DFNNIRINWT 450
WHNVLSRPGN DECPWGHSCP DGCITGVYTD AYPLNPSGSI VSSVILDSQK 500
SRENPIITYS TATNRVNELA IYNRTLPAAY TTTNCITHYD KGYCFHIVEI 550
NHRSLNTFQP MLFKTEVPKN CS 572
Length:572
Mass (Da):64,590
Last modified:January 1, 1988 - v1
Checksum:iDDF84E90C4EC87B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00114 Genomic RNA. Translation: CAA68298.1.
D84095 Genomic RNA. Translation: BAA12218.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00114 Genomic RNA. Translation: CAA68298.1 .
D84095 Genomic RNA. Translation: BAA12218.1 .

3D structure databases

ProteinModelPortali P06167.
SMRi P06167. Positions 142-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins."
    Suzu S., Sakai Y., Shioda T., Shibuta H.
    Nucleic Acids Res. 15:2945-2958(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: 910N.

Entry informationi

Entry nameiHN_PI3B
AccessioniPrimary (citable) accession number: P06167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi