P06157 (MATRX_NDVB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Matrix protein

Gene names

Name:

M

Organism

Newcastle disease virus (strain Beaudette C/45) (NDV)

Taxonomic identifier

11178 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Avulavirus › Newcastle disease virus

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
Subcellular location	Virion Potential.
Domain	Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. The matrix protein contains one L domain: a FPIV motif By similarity.
Sequence similarities	Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral budding Viral budding via the host ESCRT complexes Virus exit from host cell
Cellular component	Viral envelope protein Viral matrix protein Virion
Gene Ontology (GO)
Biological_process	viral release from host cell Inferred from electronic annotation. Source: UniProtKB-KW virion assembly Inferred from electronic annotation. Source: InterPro virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Matrix protein		PRO_0000142760
Regions
	Motif	23 – 26	4	FPIV motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06157 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 214C35E23CA2E81A	FASTA	364	39,605
	10 20 30 40 50 60 MDSSRTIGLY FDSAHSSSNL LAFPIVLQDT GDGKKQIAPQ YRIQRLDSWT DSKEDSVFIT 70 80 90 100 110 120 TYGFIFQVGN EEATVGMIND NPKRELLSAA MLCLGSVPNT GDLVELARAC LTMVVTCKKS 130 140 150 160 170 180 ATNTERMVFS VVQAPQVLQS CRVVANKYSS VNAVKHVKAP EKIPGSGTLE YKVNFVSLTV 190 200 210 220 230 240 VPKKDVYKIP TAVLKVSGSS LYNLALNVTI NVEVDSRSPL VKSLSKSDSG YYANLFLHIG 250 260 270 280 290 300 LMTTVDRRGK KVTFDKLEKK IRSLDLSVGL SDVLGPSVLV KARGARTKLL APFFSSSGTA 310 320 330 340 350 360 CYPIANASPQ VAKILWSQTA CLRSVKIIIQ AGTQRTVAVT ADHEVTSTKL EKGHTLAKYN PFKK

References

[1]	"Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus." Chambers P., Millar N.S., Platt S.G., Emmerson P.T. Nucleic Acids Res. 14:9051-9061(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04687 Genomic RNA. Translation: CAA28389.1.
PIR	MFNZNC. A26111.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000982. Matrix. [Graphical view]
Pfam	PF00661. Matrix. 1 hit. [Graphical view]
ProDom	PD000741. Matrix. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MATRX_NDVB

Accession

Primary (citable) accession number: P06157

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program