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Protein

Cell division protein FtsQ

Gene

ftsQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.UniRule annotation2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • barrier septum assembly Source: EcoliWiki
  • cell division Source: EcoliWiki
  • FtsZ-dependent cytokinesis Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG10342-MONOMER.
ECOL316407:JW0091-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsQUniRule annotation
Gene namesi
Name:ftsQUniRule annotation
Ordered Locus Names:b0093, JW0091
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10342. ftsQ.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicUniRule annotationAdd
BLAST
Transmembranei28 – 4821HelicalUniRule annotationAdd
BLAST
Topological domaini49 – 276228PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi29 – 291L → R: No change in activity. Correctly assembled, interacts with FtsB and FtsL, but fails to localize efficiently to the cell division site; when associated with R-32. Does not insert into the membrane and lack of activity; when associated with R-32 and P-38. 1 Publication
Mutagenesisi32 – 321L → R: No change in activity. Correctly assembled, interacts with FtsB and FtsL, but fails to localize efficiently to the cell division site; when associated with R-29. Does not insert into the membrane and lack of activity; when associated with R-29 and P-38. 1 Publication
Mutagenesisi38 – 381V → P: No change in activity. Does not insert into the membrane and lack of activity; when associated with R-29 and R-32. 1 Publication
Mutagenesisi91 – 911D → K or Q: Does not affect localization. 1 Publication
Mutagenesisi113 – 1131K → D: Impairs localization. 1 Publication
Mutagenesisi125 – 1251E → K: Impairs localization. 1 Publication
Mutagenesisi237 – 2371D → N: Localizes to mid-cell, but is unable to form a functional complex with FtsL/FtsB. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Cell division protein FtsQPRO_0000160580Add
BLAST

Proteomic databases

PaxDbiP06136.
PRIDEiP06136.

Expressioni

Inductioni

Repressed by hydroxyurea.1 Publication

Interactioni

Subunit structurei

Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts with FtsA, FtsK, FtsL, FtsB, FtsW, FtsI, FtsN, FtsX and YmgF.UniRule annotation4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-1130157,EBI-1130157
ftsBP0A6S510EBI-1130157,EBI-1113953
ftsIP0AD685EBI-1130157,EBI-548564
ftsKP468893EBI-1130157,EBI-550795
ftsLP0AEN411EBI-1130157,EBI-1119082
ftsNP291317EBI-1130157,EBI-1134233
ftsWP0ABG43EBI-1130157,EBI-1214767
ymgFP580343EBI-1130157,EBI-1214577

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4261112. 319 interactions.
DIPiDIP-9706N.
IntActiP06136. 19 interactions.
MINTiMINT-1031860.
STRINGi511145.b0093.

Structurei

Secondary structure

1
276
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 646Combined sources
Helixi71 – 799Combined sources
Helixi87 – 893Combined sources
Helixi92 – 10211Combined sources
Beta strandi106 – 1149Combined sources
Turni115 – 1173Combined sources
Beta strandi118 – 1258Combined sources
Beta strandi128 – 1325Combined sources
Turni133 – 1353Combined sources
Beta strandi136 – 1394Combined sources
Helixi149 – 1513Combined sources
Turni152 – 1543Combined sources
Beta strandi159 – 1613Combined sources
Helixi167 – 18216Combined sources
Beta strandi190 – 1934Combined sources
Beta strandi195 – 1973Combined sources
Beta strandi199 – 2024Combined sources
Beta strandi204 – 2063Combined sources
Beta strandi208 – 2147Combined sources
Helixi216 – 23621Combined sources
Beta strandi239 – 24810Combined sources
Beta strandi251 – 2588Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VH1X-ray2.70A/B58-276[»]
4UE4electron microscopy7.00B29-50[»]
4V6Melectron microscopy7.1Z22-103[»]
ProteinModelPortaliP06136.
SMRiP06136. Positions 58-260.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06136.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 12672POTRAPROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal periplasmic region is necessary and sufficient for septal targeting. The transmembrane region contributes to localization to the cell division site. Three periplasmic subdomains are involved in the interactions with other cell division proteins. Localization and recruitment require two separate domains.5 Publications

Sequence similaritiesi

Belongs to the FtsQ/DivIB family. FtsQ subfamily.UniRule annotation
Contains 1 POTRA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105K7E. Bacteria.
COG1589. LUCA.
HOGENOMiHOG000255872.
InParanoidiP06136.
KOiK03589.
OMAiVFEAPSH.
PhylomeDBiP06136.

Family and domain databases

HAMAPiMF_00911. FtsQ_subfam. 1 hit.
InterProiIPR005548. Cell_div_FtsQ/DivIB.
IPR026579. FtsQ.
IPR013685. POTRA_FtsQ_type.
[Graphical view]
PfamiPF03799. FtsQ. 1 hit.
PF08478. POTRA_1. 1 hit.
[Graphical view]
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAALNTRN SEEEVSSRRN NGTRLAGILF LLTVLTTVLV SGWVVLGWME
60 70 80 90 100
DAQRLPLSKL VLTGERHYTR NDDIRQSILA LGEPGTFMTQ DVNIIQTQIE
110 120 130 140 150
QRLPWIKQVS VRKQWPDELK IHLVEYVPIA RWNDQHMVDA EGNTFSVPPE
160 170 180 190 200
RTSKQVLPML YGPEGSANEV LQGYREMGQM LAKDRFTLKE AAMTARRSWQ
210 220 230 240 250
LTLNNDIKLN LGRGDTMKRL ARFVELYPVL QQQAQTDGKR ISYVDLRYDS
260 270
GAAVGWAPLP PEESTQQQNQ AQAEQQ
Length:276
Mass (Da):31,434
Last modified:January 1, 1988 - v1
Checksum:i839A3D34B948CEAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14029 Genomic DNA. Translation: AAA23673.1.
K02668 Genomic DNA. Translation: AAA23816.1.
X55034 Genomic DNA. Translation: CAA38870.1.
U00096 Genomic DNA. Translation: AAC73204.1.
AP009048 Genomic DNA. Translation: BAB96661.1.
PIRiS10852. CEECQ.
RefSeqiNP_414635.1. NC_000913.3.
WP_000075748.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73204; AAC73204; b0093.
BAB96661; BAB96661; BAB96661.
GeneIDi944823.
KEGGiecj:JW0091.
eco:b0093.
PATRICi32115291. VBIEscCol129921_0097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14029 Genomic DNA. Translation: AAA23673.1.
K02668 Genomic DNA. Translation: AAA23816.1.
X55034 Genomic DNA. Translation: CAA38870.1.
U00096 Genomic DNA. Translation: AAC73204.1.
AP009048 Genomic DNA. Translation: BAB96661.1.
PIRiS10852. CEECQ.
RefSeqiNP_414635.1. NC_000913.3.
WP_000075748.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VH1X-ray2.70A/B58-276[»]
4UE4electron microscopy7.00B29-50[»]
4V6Melectron microscopy7.1Z22-103[»]
ProteinModelPortaliP06136.
SMRiP06136. Positions 58-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261112. 319 interactions.
DIPiDIP-9706N.
IntActiP06136. 19 interactions.
MINTiMINT-1031860.
STRINGi511145.b0093.

Proteomic databases

PaxDbiP06136.
PRIDEiP06136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73204; AAC73204; b0093.
BAB96661; BAB96661; BAB96661.
GeneIDi944823.
KEGGiecj:JW0091.
eco:b0093.
PATRICi32115291. VBIEscCol129921_0097.

Organism-specific databases

EchoBASEiEB0338.
EcoGeneiEG10342. ftsQ.

Phylogenomic databases

eggNOGiENOG4105K7E. Bacteria.
COG1589. LUCA.
HOGENOMiHOG000255872.
InParanoidiP06136.
KOiK03589.
OMAiVFEAPSH.
PhylomeDBiP06136.

Enzyme and pathway databases

BioCyciEcoCyc:EG10342-MONOMER.
ECOL316407:JW0091-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP06136.
PROiP06136.

Family and domain databases

HAMAPiMF_00911. FtsQ_subfam. 1 hit.
InterProiIPR005548. Cell_div_FtsQ/DivIB.
IPR026579. FtsQ.
IPR013685. POTRA_FtsQ_type.
[Graphical view]
PfamiPF03799. FtsQ. 1 hit.
PF08478. POTRA_1. 1 hit.
[Graphical view]
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSQ_ECOLI
AccessioniPrimary (citable) accession number: P06136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.