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Protein

UDP-glucuronosyltransferase 2B4

Gene

UGT2B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: BHF-UCL

GO - Biological processi

  • cellular glucuronidation Source: BHF-UCL
  • cellular response to hormone stimulus Source: GO_Central
  • estrogen catabolic process Source: UniProtKB
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: GO_Central
  • metabolic process Source: UniProtKB
  • xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B4 (EC:2.4.1.17)
Short name:
UDPGT 2B4
Alternative name(s):
HLUG25
Hyodeoxycholic acid-specific UDPGT
UDPGTh-1
Gene namesi
Name:UGT2B4
Synonyms:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12553. UGT2B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 50917HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA360.

Chemistry

DrugBankiDB08907. Canagliflozin.
DB00318. Codeine.
DB06292. Dapagliflozin.
DB00712. Flurbiprofen.
DB01050. Ibuprofen.
DB00295. Morphine.

Polymorphism and mutation databases

BioMutaiUGT2B4.
DMDMi6175083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 2B4PRO_0000036028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351N6-succinyllysineBy similarity
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP06133.
PaxDbiP06133.
PRIDEiP06133.

PTM databases

PhosphoSiteiP06133.

Expressioni

Gene expression databases

BgeeiP06133.
CleanExiHS_UGT2B11.
HS_UGT2B4.
ExpressionAtlasiP06133. baseline and differential.
GenevisibleiP06133. HS.

Organism-specific databases

HPAiCAB033260.
HPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113210. 1 interaction.
IntActiP06133. 1 interaction.
STRINGi9606.ENSP00000305221.

Structurei

3D structure databases

ProteinModelPortaliP06133.
SMRiP06133. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP06133.
KOiK00699.
OMAiWAELPKD.
OrthoDBiEOG7GBFWS.
PhylomeDBiP06133.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P06133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLASSA SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL
110 120 130 140 150
PKDTFWSYFS QVQEIMWTFN DILRKFCKDI VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DAVFPFGELL AELLKIPFVY SLRFSPGYAI EKHSGGLLFP PSYVPVVMSE
210 220 230 240 250
LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP
410 420 430 440 450
DNIAHMKAKG AAVSLDFHTM SSTDLLNALK TVINDPLYKE NAMKLSRIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVTGFLLAC
510 520
VATVIFIITK CLFCVWKFVR TGKKGKRD
Length:528
Mass (Da):60,513
Last modified:December 15, 1998 - v2
Checksum:i6B45E6769971A078
GO
Isoform 2 (identifier: P06133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MSMKWTSALLLIQL → MFFALLHVSSTNGL
     15-150: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):44,593
Checksum:i86803DC78D6790A6
GO
Isoform 3 (identifier: P06133-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-369: GHPKTR → DIKRML
     370-528: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):42,723
Checksum:i0590B6A6B4D29FCE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1722SL → RP in CAA68415 (PubMed:3109396).Curated
Sequence conflicti291 – 2933EME → KWK in AAC32272 (Ref. 4) Curated
Sequence conflicti309 – 3091L → V in AAS47487 (Ref. 6) 1 Publication
Sequence conflicti354 – 3541Y → H in AAS47487 (Ref. 6) 1 Publication
Sequence conflicti382 – 3876EAIYHG → KAISPR in CAA68415 (PubMed:3109396).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401K → N.1 Publication
Corresponds to variant rs41299974 [ dbSNP | Ensembl ].
VAR_060713
Natural varianti78 – 781P → T.1 Publication
Corresponds to variant rs41299976 [ dbSNP | Ensembl ].
VAR_060714
Natural varianti80 – 801S → P.1 Publication
Corresponds to variant rs41299978 [ dbSNP | Ensembl ].
VAR_060715
Natural varianti109 – 1091F → L.1 Publication
VAR_011328
Natural varianti277 – 2771V → I.1 Publication
Corresponds to variant rs41300004 [ dbSNP | Ensembl ].
VAR_060716
Natural varianti396 – 3961F → L.1 Publication
VAR_011329
Natural varianti458 – 4581D → E.2 Publications
Corresponds to variant rs13119049 [ dbSNP | Ensembl ].
VAR_007712
Natural varianti511 – 5111C → R.1 Publication
VAR_060717

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MSMKW…LLIQL → MFFALLHVSSTNGL in isoform 2. 1 PublicationVSP_056679Add
BLAST
Alternative sequencei15 – 150136Missing in isoform 2. 1 PublicationVSP_056680Add
BLAST
Alternative sequencei364 – 3696GHPKTR → DIKRML in isoform 3. 1 PublicationVSP_056869
Alternative sequencei370 – 528159Missing in isoform 3. 1 PublicationVSP_056870Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00317 mRNA. Translation: CAA68415.1.
AF064200 mRNA. Translation: AAC95002.1.
AJ005162 mRNA. Translation: CAA06396.1.
AF081793 mRNA. Translation: AAC32272.1.
AF135416 Genomic DNA. Translation: AAF78145.1.
AY529122 mRNA. Translation: AAS47487.1.
DQ520733 Genomic DNA. Translation: ABF47107.1.
AK292748 mRNA. Translation: BAF85437.1.
AK300084 mRNA. Translation: BAG61887.1.
AC093829 Genomic DNA. No translation available.
AC108078 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05591.1.
BC026264 mRNA. Translation: AAH26264.1.
CCDSiCCDS43234.1. [P06133-1]
CCDS75137.1. [P06133-3]
PIRiJN0619.
RefSeqiNP_001284544.1. NM_001297615.1. [P06133-3]
NP_001284545.1. NM_001297616.1. [P06133-2]
NP_066962.2. NM_021139.2. [P06133-1]
UniGeneiHs.285887.

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096.
ENST00000512583; ENSP00000421290; ENSG00000156096. [P06133-3]
GeneIDi7363.
KEGGihsa:7363.
UCSCiuc003hek.4. human. [P06133-1]
uc003hel.4. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00317 mRNA. Translation: CAA68415.1.
AF064200 mRNA. Translation: AAC95002.1.
AJ005162 mRNA. Translation: CAA06396.1.
AF081793 mRNA. Translation: AAC32272.1.
AF135416 Genomic DNA. Translation: AAF78145.1.
AY529122 mRNA. Translation: AAS47487.1.
DQ520733 Genomic DNA. Translation: ABF47107.1.
AK292748 mRNA. Translation: BAF85437.1.
AK300084 mRNA. Translation: BAG61887.1.
AC093829 Genomic DNA. No translation available.
AC108078 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05591.1.
BC026264 mRNA. Translation: AAH26264.1.
CCDSiCCDS43234.1. [P06133-1]
CCDS75137.1. [P06133-3]
PIRiJN0619.
RefSeqiNP_001284544.1. NM_001297615.1. [P06133-3]
NP_001284545.1. NM_001297616.1. [P06133-2]
NP_066962.2. NM_021139.2. [P06133-1]
UniGeneiHs.285887.

3D structure databases

ProteinModelPortaliP06133.
SMRiP06133. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113210. 1 interaction.
IntActiP06133. 1 interaction.
STRINGi9606.ENSP00000305221.

Chemistry

ChEMBLiCHEMBL6196.
DrugBankiDB08907. Canagliflozin.
DB00318. Codeine.
DB06292. Dapagliflozin.
DB00712. Flurbiprofen.
DB01050. Ibuprofen.
DB00295. Morphine.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiP06133.

Polymorphism and mutation databases

BioMutaiUGT2B4.
DMDMi6175083.

Proteomic databases

MaxQBiP06133.
PaxDbiP06133.
PRIDEiP06133.

Protocols and materials databases

DNASUi7363.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096.
ENST00000512583; ENSP00000421290; ENSG00000156096. [P06133-3]
GeneIDi7363.
KEGGihsa:7363.
UCSCiuc003hek.4. human. [P06133-1]
uc003hel.4. human.

Organism-specific databases

CTDi7363.
GeneCardsiGC04M070345.
HGNCiHGNC:12553. UGT2B4.
HPAiCAB033260.
HPA045108.
MIMi600067. gene.
neXtProtiNX_P06133.
PharmGKBiPA360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP06133.
KOiK00699.
OMAiWAELPKD.
OrthoDBiEOG7GBFWS.
PhylomeDBiP06133.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Miscellaneous databases

ChiTaRSiUGT2B4. human.
GeneWikiiUGT2B4.
GenomeRNAii7363.
NextBioi28828.
PROiP06133.
SOURCEiSearch...

Gene expression databases

BgeeiP06133.
CleanExiHS_UGT2B11.
HS_UGT2B4.
ExpressionAtlasiP06133. baseline and differential.
GenevisibleiP06133. HS.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA."
    Jackson M.R., McCarthy L.R., Harding D., Wilson S., Coughtrie M.W.H., Burchell B.
    Biochem. J. 242:581-588(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."
    Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I.
    Biochem. Biophys. Res. Commun. 194:496-503(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene."
    Levesque E., Beaulieu M., Hum D.W., Belanger A.
    Pharmacogenetics 9:207-216(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-458, CHARACTERIZATION.
  4. McKenzie P.I.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS LEU-109 AND LEU-396.
  5. "Genomic organization and structure of the UGT2B gene complex at human chromosome 4q13."
    Riedy M., Miller A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Shen C., Ke R., Wang C., Li H., Zhou G., Zhong G., Lin L., Yang S.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  7. NIEHS SNPs program
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-40; THR-78; PRO-80; ILE-277; GLU-458 AND ARG-511.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver and Pericardium.
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-315.
    Tissue: Liver.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUD2B4_HUMAN
AccessioniPrimary (citable) accession number: P06133
Secondary accession number(s): A6NCP7
, B4DT75, G5E9X8, O60731, O60867, O75614, P36538, Q1HBF9, Q6QQX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 15, 1998
Last modified: July 22, 2015
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another human enzyme.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.