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P06133

- UD2B4_HUMAN

UniProt

P06133 - UD2B4_HUMAN

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Protein
UDP-glucuronosyltransferase 2B4
Gene
UGT2B4, UGT2B11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: BHF-UCL

GO - Biological processi

  1. cellular glucuronidation Source: BHF-UCL
  2. estrogen catabolic process Source: UniProtKB
  3. metabolic process Source: UniProtKB
  4. xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B4 (EC:2.4.1.17)
Short name:
UDPGT 2B4
Alternative name(s):
HLUG25
Hyodeoxycholic acid-specific UDPGT
UDPGTh-1
Gene namesi
Name:UGT2B4
Synonyms:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12553. UGT2B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 50917Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 2B4
PRO_0000036028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP06133.
PaxDbiP06133.
PRIDEiP06133.

PTM databases

PhosphoSiteiP06133.

Expressioni

Gene expression databases

ArrayExpressiP06133.
BgeeiP06133.
CleanExiHS_UGT2B11.
HS_UGT2B4.
GenevestigatoriP06133.

Organism-specific databases

HPAiCAB033260.
HPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113210. 1 interaction.
IntActiP06133. 1 interaction.
STRINGi9606.ENSP00000305221.

Structurei

3D structure databases

ProteinModelPortaliP06133.
SMRiP06133. Positions 285-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP06133.
KOiK00699.
OMAiKQLVKRW.
PhylomeDBiP06133.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06133-1 [UniParc]FASTAAdd to Basket

« Hide

MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG    50
HEVTVLASSA SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL 100
PKDTFWSYFS QVQEIMWTFN DILRKFCKDI VSNKKLMKKL QESRFDVVLA 150
DAVFPFGELL AELLKIPFVY SLRFSPGYAI EKHSGGLLFP PSYVPVVMSE 200
LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL GRPTTLSETM 250
AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 300
ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN 350
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP 400
DNIAHMKAKG AAVSLDFHTM SSTDLLNALK TVINDPLYKE NAMKLSRIHH 450
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVTGFLLAC 500
VATVIFIITK CLFCVWKFVR TGKKGKRD 528
Length:528
Mass (Da):60,513
Last modified:December 15, 1998 - v2
Checksum:i6B45E6769971A078
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401K → N.1 Publication
Corresponds to variant rs41299974 [ dbSNP | Ensembl ].
VAR_060713
Natural varianti78 – 781P → T.1 Publication
Corresponds to variant rs41299976 [ dbSNP | Ensembl ].
VAR_060714
Natural varianti80 – 801S → P.1 Publication
Corresponds to variant rs41299978 [ dbSNP | Ensembl ].
VAR_060715
Natural varianti109 – 1091F → L.1 Publication
VAR_011328
Natural varianti277 – 2771V → I.1 Publication
Corresponds to variant rs41300004 [ dbSNP | Ensembl ].
VAR_060716
Natural varianti396 – 3961F → L.1 Publication
VAR_011329
Natural varianti458 – 4581D → E.2 Publications
Corresponds to variant rs13119049 [ dbSNP | Ensembl ].
VAR_007712
Natural varianti511 – 5111C → R.1 Publication
VAR_060717

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1722SL → RP in CAA68415. 1 Publication
Sequence conflicti291 – 2933EME → KWK in AAC32272. 1 Publication
Sequence conflicti382 – 3876EAIYHG → KAISPR in CAA68415. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00317 mRNA. Translation: CAA68415.1.
AF064200 mRNA. Translation: AAC95002.1.
AJ005162 mRNA. Translation: CAA06396.1.
AF081793 mRNA. Translation: AAC32272.1.
AF135416 Genomic DNA. Translation: AAF78145.1.
DQ520733 Genomic DNA. Translation: ABF47107.1.
AK292748 mRNA. Translation: BAF85437.1.
BC026264 mRNA. Translation: AAH26264.1.
CCDSiCCDS43234.1.
PIRiJN0619.
RefSeqiNP_066962.2. NM_021139.2.
UniGeneiHs.285887.

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096.
GeneIDi7363.
KEGGihsa:7363.
UCSCiuc003hek.4. human.

Polymorphism databases

DMDMi6175083.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00317 mRNA. Translation: CAA68415.1 .
AF064200 mRNA. Translation: AAC95002.1 .
AJ005162 mRNA. Translation: CAA06396.1 .
AF081793 mRNA. Translation: AAC32272.1 .
AF135416 Genomic DNA. Translation: AAF78145.1 .
DQ520733 Genomic DNA. Translation: ABF47107.1 .
AK292748 mRNA. Translation: BAF85437.1 .
BC026264 mRNA. Translation: AAH26264.1 .
CCDSi CCDS43234.1.
PIRi JN0619.
RefSeqi NP_066962.2. NM_021139.2.
UniGenei Hs.285887.

3D structure databases

ProteinModelPortali P06133.
SMRi P06133. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113210. 1 interaction.
IntActi P06133. 1 interaction.
STRINGi 9606.ENSP00000305221.

Chemistry

ChEMBLi CHEMBL6196.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P06133.

Polymorphism databases

DMDMi 6175083.

Proteomic databases

MaxQBi P06133.
PaxDbi P06133.
PRIDEi P06133.

Protocols and materials databases

DNASUi 7363.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305107 ; ENSP00000305221 ; ENSG00000156096 .
GeneIDi 7363.
KEGGi hsa:7363.
UCSCi uc003hek.4. human.

Organism-specific databases

CTDi 7363.
GeneCardsi GC04M070345.
HGNCi HGNC:12553. UGT2B4.
HPAi CAB033260.
HPA045108.
MIMi 600067. gene.
neXtProti NX_P06133.
PharmGKBi PA360.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P06133.
KOi K00699.
OMAi KQLVKRW.
PhylomeDBi P06133.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 2681.
Reactomei REACT_6784. Glucuronidation.

Miscellaneous databases

ChiTaRSi UGT2B4. human.
GeneWikii UGT2B4.
GenomeRNAii 7363.
NextBioi 28828.
PROi P06133.
SOURCEi Search...

Gene expression databases

ArrayExpressi P06133.
Bgeei P06133.
CleanExi HS_UGT2B11.
HS_UGT2B4.
Genevestigatori P06133.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA."
    Jackson M.R., McCarthy L.R., Harding D., Wilson S., Coughtrie M.W.H., Burchell B.
    Biochem. J. 242:581-588(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."
    Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I.
    Biochem. Biophys. Res. Commun. 194:496-503(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene."
    Levesque E., Beaulieu M., Hum D.W., Belanger A.
    Pharmacogenetics 9:207-216(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-458, CHARACTERIZATION.
  4. McKenzie P.I.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-109 AND LEU-396.
  5. "Genomic organization and structure of the UGT2B gene complex at human chromosome 4q13."
    Riedy M., Miller A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. NIEHS SNPs program
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-40; THR-78; PRO-80; ILE-277; GLU-458 AND ARG-511.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-315.
    Tissue: Liver.

Entry informationi

Entry nameiUD2B4_HUMAN
AccessioniPrimary (citable) accession number: P06133
Secondary accession number(s): O60731
, O60867, O75614, P36538, Q1HBF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 15, 1998
Last modified: September 3, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

1 Publication thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another human enzyme.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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