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P06131

- FDHA_METFO

UniProt

P06131 - FDHA_METFO

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Protein

Formate dehydrogenase subunit alpha

Gene
fdhA
Organism
Methanobacterium formicicum
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of formate.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.
Zinc.
FAD.
Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101Iron-sulfur (4Fe-4S) By similarity
Metal bindingi13 – 131Iron-sulfur (4Fe-4S) By similarity
Metal bindingi17 – 171Iron-sulfur (4Fe-4S) By similarity
Metal bindingi45 – 451Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: InterPro
  3. formate dehydrogenase (coenzyme F420) activity Source: MENGO
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD, Zinc

Enzyme and pathway databases

SABIO-RKP06131.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit alpha (EC:1.2.1.2)
Gene namesi
Name:fdhA
OrganismiMethanobacterium formicicum
Taxonomic identifieri2162 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Formate dehydrogenase subunit alphaPRO_0000063225Add
BLAST

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliP06131.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 59574Fe-4S Mo/W bis-MGD-typeAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06131-1 [UniParc]FASTAAdd to Basket

« Hide

MDIKYVPTIC PYCGVGCGMN LVVKDEKVVG VEPWKRHPVN EGKLCPKGNF    50
CYEIIHREDR LTTPLIKENG EFREATWDEA YDLIASKLGA YDPNEIGFFC 100
CARSPNENIY VNQKFARIVV GTHNIDHCAR LCHGPTVAGL AASFGSGAMT 150
NSYASFEDAD LIFSIGANSL EAHPLVGRKL MRAKMNGAYF IVADPRYTPT 200
AKQADQYIPF KTGTDVALMN AMMNVIISEG LEDKEFIEKR TKNYEELKEV 250
VSKYTPEMAE EITQVPADVI RDIAIKYAKA DKAAIVYSLG ITEHSHGVDN 300
VMQTANLAML TGNIGRLGTG VNPLRGQNNV QGACDMGALP TDYPGYRKVA 350
DQEVMEDVTC TWGCSDLGCE PGLKIPEMID AAAKGDLKVL YITGEDPVIS 400
DPDTHHVEEA LNNLDFFVVQ DIFMTDTAEF ADVVLPAACW AEQEGTFTNG 450
ERRVQLIRKA VDAPGESKYD WEIFCDLAKK MGADPEMFTY ESAQDIFEEV 500
RTVTPQYAGM NRERLDRPEA LHWPCPSEDH PGTAMMHIEK FAHPDGLGIF 550
MPLEEQGPME TPDDEYPLIL TTTRLLFHYH AAMTRRAATL DREVPTGYVE 600
INTEDAAELG IANKEKVKVK SRRGEIEIAA RVTDDIVKGI VNIPMHFREC 650
SANILTNAAA IDPKSGMPEY KACAVAISKM EGSK 684
Length:684
Mass (Da):75,717
Last modified:January 1, 1988 - v1
Checksum:i38D37CF86BFF06E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02581 Genomic DNA. Translation: AAA72182.1.
PIRiA24698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02581 Genomic DNA. Translation: AAA72182.1 .
PIRi A24698.

3D structure databases

ProteinModelPortali P06131.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P06131.

Family and domain databases

InterProi IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum."
    Shuber A.P., Orr E.C., Recny M.A., Schendel P.F., May H.D., Schauer N.L., Ferry J.G.
    J. Biol. Chem. 261:12942-12947(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-26.
    Strain: JF-1.
  2. "Identification of formate dehydrogenase-specific mRNA species and nucleotide sequence of the fdhC gene of Methanobacterium formicicum."
    White W.B., Ferry J.G.
    J. Bacteriol. 174:4997-5004(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    Strain: JF-1.

Entry informationi

Entry nameiFDHA_METFO
AccessioniPrimary (citable) accession number: P06131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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