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P06130

- FDHB_METFO

UniProt

P06130 - FDHB_METFO

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Protein
Formate dehydrogenase subunit beta
Gene
fdhB
Organism
Methanobacterium formicicum
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of formate.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 2 4Fe-4S clusters Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi296 – 2961Iron-sulfur (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur (4Fe-4S) By similarity
Metal bindingi302 – 3021Iron-sulfur (4Fe-4S) By similarity
Metal bindingi306 – 3061Iron-sulfur (4Fe-4S) By similarity
Metal bindingi348 – 3481Iron-sulfur (4Fe-4S) By similarity
Metal bindingi351 – 3511Iron-sulfur (4Fe-4S) By similarity
Metal bindingi354 – 3541Iron-sulfur (4Fe-4S) By similarity
Metal bindingi358 – 3581Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. formate dehydrogenase (coenzyme F420) activity Source: MENGO
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

SABIO-RKP06130.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit beta (EC:1.2.1.2)
Gene namesi
Name:fdhB
OrganismiMethanobacterium formicicum
Taxonomic identifieri2162 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Formate dehydrogenase subunit beta
PRO_0000159222Add
BLAST

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliP06130.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 316304Fe-4S ferredoxin-type 1
Add
BLAST
Domaini339 – 367294Fe-4S ferredoxin-type 2
Add
BLAST

Sequence similaritiesi

Belongs to the FrhB family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamiPF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06130-1 [UniParc]FASTAAdd to Basket

« Hide

MINTNDMFYA KSSDAEIAEA GEYGGAVTTL LKFLLKEGIV DAVLAVDSSA    50
DLYDVVPILI EDPEDVVKAA GSLHFGTLNL AKVVTRYLDG AQDMKIAVTV 100
KPCDAMTMVE LMKREKVNAD NVIMVGLNCG GTMPPVKGRQ MMEEFYEVDP 150
DSVVKEEIAK GKLIVETEDG TEKEIPIDEL EDEGFGRRTN CRRCEVNIPR 200
MADLACGNWG VIGPLAGKAT FIEVCSPKGA EVLEKAKEAG VIDLEDPIPK 250
GIEIREKIDG AMVKLADKWQ GNDWEDKAGR EIFSVLTEYM DDFSRCLKCY 300
GCREACPICY CEDCCLEANN GPDWLSKGEI PPSPMFHLER MLHMVESCTN 350
CGQCEEVCPG EIPLAKIWHE VNAKMKDTFG YVKGTGDEKP PIAYFPVGK 399
Length:399
Mass (Da):43,922
Last modified:January 1, 1988 - v1
Checksum:iD57F778C6C8F67BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02581 Genomic DNA. Translation: AAA72183.1.
PIRiB24698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02581 Genomic DNA. Translation: AAA72183.1 .
PIRi B24698.

3D structure databases

ProteinModelPortali P06130.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P06130.

Family and domain databases

InterProi IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view ]
Pfami PF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum."
    Shuber A.P., Orr E.C., Recny M.A., Schendel P.F., May H.D., Schauer N.L., Ferry J.G.
    J. Biol. Chem. 261:12942-12947(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-22.
    Strain: JF-1.

Entry informationi

Entry nameiFDHB_METFO
AccessioniPrimary (citable) accession number: P06130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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