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P06130 (FDHB_METFO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase subunit beta

EC=1.2.1.2
Gene names
Name:fdhB
OrganismMethanobacterium formicicum
Taxonomic identifier2162 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidation of formate.

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Cofactor

Binds 2 4Fe-4S clusters Probable.

Subunit structure

Dimer of an alpha and a beta subunit.

Sequence similarities

Belongs to the FrhB family.

Contains 2 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Formate dehydrogenase subunit beta
PRO_0000159222

Regions

Domain287 – 316304Fe-4S ferredoxin-type 1
Domain339 – 367294Fe-4S ferredoxin-type 2

Sites

Metal binding2961Iron-sulfur (4Fe-4S) By similarity
Metal binding2991Iron-sulfur (4Fe-4S) By similarity
Metal binding3021Iron-sulfur (4Fe-4S) By similarity
Metal binding3061Iron-sulfur (4Fe-4S) By similarity
Metal binding3481Iron-sulfur (4Fe-4S) By similarity
Metal binding3511Iron-sulfur (4Fe-4S) By similarity
Metal binding3541Iron-sulfur (4Fe-4S) By similarity
Metal binding3581Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P06130 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: D57F778C6C8F67BB

FASTA39943,922
        10         20         30         40         50         60 
MINTNDMFYA KSSDAEIAEA GEYGGAVTTL LKFLLKEGIV DAVLAVDSSA DLYDVVPILI 

        70         80         90        100        110        120 
EDPEDVVKAA GSLHFGTLNL AKVVTRYLDG AQDMKIAVTV KPCDAMTMVE LMKREKVNAD 

       130        140        150        160        170        180 
NVIMVGLNCG GTMPPVKGRQ MMEEFYEVDP DSVVKEEIAK GKLIVETEDG TEKEIPIDEL 

       190        200        210        220        230        240 
EDEGFGRRTN CRRCEVNIPR MADLACGNWG VIGPLAGKAT FIEVCSPKGA EVLEKAKEAG 

       250        260        270        280        290        300 
VIDLEDPIPK GIEIREKIDG AMVKLADKWQ GNDWEDKAGR EIFSVLTEYM DDFSRCLKCY 

       310        320        330        340        350        360 
GCREACPICY CEDCCLEANN GPDWLSKGEI PPSPMFHLER MLHMVESCTN CGQCEEVCPG 

       370        380        390 
EIPLAKIWHE VNAKMKDTFG YVKGTGDEKP PIAYFPVGK 

« Hide

References

[1]"Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum."
Shuber A.P., Orr E.C., Recny M.A., Schendel P.F., May H.D., Schauer N.L., Ferry J.G.
J. Biol. Chem. 261:12942-12947(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-22.
Strain: JF-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02581 Genomic DNA. Translation: AAA72183.1.
PIRB24698.

3D structure databases

ProteinModelPortalP06130.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP06130.

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamPF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDHB_METFO
AccessionPrimary (citable) accession number: P06130
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families