Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P06130

- FDHB_METFO

UniProt

P06130 - FDHB_METFO

Protein

Formate dehydrogenase subunit beta

Gene

fdhB

Organism
Methanobacterium formicicum
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of formate.

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 2 4Fe-4S clusters.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi296 – 2961Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi299 – 2991Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi302 – 3021Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi306 – 3061Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi348 – 3481Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi351 – 3511Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi354 – 3541Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi358 – 3581Iron-sulfur (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. formate dehydrogenase (coenzyme F420) activity Source: MENGO
    3. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

    Enzyme and pathway databases

    SABIO-RKP06130.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase subunit beta (EC:1.2.1.2)
    Gene namesi
    Name:fdhB
    OrganismiMethanobacterium formicicum
    Taxonomic identifieri2162 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Formate dehydrogenase subunit betaPRO_0000159222Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer of an alpha and a beta subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliP06130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini287 – 316304Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini339 – 367294Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FrhB family.Curated
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR007516. Co_F420_Hydgase/DH_bsu_N.
    IPR007525. FrhB_FdhB_C.
    IPR009051. Helical_ferredxn.
    [Graphical view]
    PfamiPF13183. Fer4_8. 1 hit.
    PF04432. FrhB_FdhB_C. 1 hit.
    PF04422. FrhB_FdhB_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINTNDMFYA KSSDAEIAEA GEYGGAVTTL LKFLLKEGIV DAVLAVDSSA    50
    DLYDVVPILI EDPEDVVKAA GSLHFGTLNL AKVVTRYLDG AQDMKIAVTV 100
    KPCDAMTMVE LMKREKVNAD NVIMVGLNCG GTMPPVKGRQ MMEEFYEVDP 150
    DSVVKEEIAK GKLIVETEDG TEKEIPIDEL EDEGFGRRTN CRRCEVNIPR 200
    MADLACGNWG VIGPLAGKAT FIEVCSPKGA EVLEKAKEAG VIDLEDPIPK 250
    GIEIREKIDG AMVKLADKWQ GNDWEDKAGR EIFSVLTEYM DDFSRCLKCY 300
    GCREACPICY CEDCCLEANN GPDWLSKGEI PPSPMFHLER MLHMVESCTN 350
    CGQCEEVCPG EIPLAKIWHE VNAKMKDTFG YVKGTGDEKP PIAYFPVGK 399
    Length:399
    Mass (Da):43,922
    Last modified:January 1, 1988 - v1
    Checksum:iD57F778C6C8F67BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02581 Genomic DNA. Translation: AAA72183.1.
    PIRiB24698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02581 Genomic DNA. Translation: AAA72183.1 .
    PIRi B24698.

    3D structure databases

    ProteinModelPortali P06130.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P06130.

    Family and domain databases

    InterProi IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR007516. Co_F420_Hydgase/DH_bsu_N.
    IPR007525. FrhB_FdhB_C.
    IPR009051. Helical_ferredxn.
    [Graphical view ]
    Pfami PF13183. Fer4_8. 1 hit.
    PF04432. FrhB_FdhB_C. 1 hit.
    PF04422. FrhB_FdhB_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum."
      Shuber A.P., Orr E.C., Recny M.A., Schendel P.F., May H.D., Schauer N.L., Ferry J.G.
      J. Biol. Chem. 261:12942-12947(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-22.
      Strain: JF-1.

    Entry informationi

    Entry nameiFDHB_METFO
    AccessioniPrimary (citable) accession number: P06130
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3