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Protein

T-cell surface glycoprotein CD5

Gene

CD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

  • receptor activity Source: UniProtKB
  • scavenger receptor activity Source: InterPro
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • apoptotic signaling pathway Source: Ensembl
  • cell proliferation Source: UniProtKB
  • cell recognition Source: UniProtKB
  • T cell costimulation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110448-MONOMER.
SIGNORiP06127.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen T1/Leu-1
CD_antigen: CD5
Gene namesi
Name:CD5
Synonyms:LEU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1685. CD5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 372ExtracellularSequence analysisAdd BLAST348
Transmembranei373 – 402HelicalSequence analysisAdd BLAST30
Topological domaini403 – 495CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi921.
OpenTargetsiENSG00000110448.
PharmGKBiPA26224.

Polymorphism and mutation databases

BioMutaiCD5.
DMDMi313104090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003322225 – 495T-cell surface glycoprotein CD5Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 86PROSITE-ProRule annotation1 Publication
Disulfide bondi60 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi81 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 117PROSITE-ProRule annotation1 Publication
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
Disulfide bondi285 ↔ 321PROSITE-ProRule annotation1 Publication
Disulfide bondi301 ↔ 360PROSITE-ProRule annotation1 Publication
Disulfide bondi316 ↔ 367PROSITE-ProRule annotation1 Publication
Disulfide bondi342 ↔ 350PROSITE-ProRule annotation1 Publication
Modified residuei439PhosphoserineCombined sources1
Modified residuei453PhosphotyrosineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP06127.
PaxDbiP06127.
PeptideAtlasiP06127.
PRIDEiP06127.

PTM databases

iPTMnetiP06127.
PhosphoSitePlusiP06127.
SwissPalmiP06127.
UniCarbKBiP06127.

Expressioni

Gene expression databases

BgeeiENSG00000110448.
CleanExiHS_CD5.
ExpressionAtlasiP06127. baseline and differential.
GenevisibleiP06127. HS.

Organism-specific databases

HPAiCAB015392.
CAB020308.
HPA043416.
HPA060839.

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107359. 14 interactors.
DIPiDIP-21N.
IntActiP06127. 3 interactors.
MINTiMINT-4656212.
STRINGi9606.ENSP00000342681.

Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 37Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi45 – 52Combined sources8
Beta strandi55 – 58Combined sources4
Helixi75 – 77Combined sources3
Helixi78 – 83Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi90 – 94Combined sources5
Turni101 – 103Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi117 – 119Combined sources3
Beta strandi122 – 124Combined sources3
Beta strandi126 – 132Combined sources7
Beta strandi275 – 280Combined sources6
Beta strandi286 – 295Combined sources10
Beta strandi298 – 301Combined sources4
Helixi310 – 318Combined sources9
Beta strandi323 – 331Combined sources9
Beta strandi339 – 341Combined sources3
Beta strandi344 – 346Combined sources3
Helixi347 – 349Combined sources3
Beta strandi354 – 356Combined sources3
Beta strandi362 – 367Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JA4X-ray2.21A270-369[»]
2JOPNMR-A25-134[»]
2JP0NMR-A25-134[»]
2OTTX-ray2.50X/Y276-368[»]
ProteinModelPortaliP06127.
SMRiP06127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06127.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST99
Domaini159 – 268SRCR 2PROSITE-ProRule annotationAdd BLAST110
Domaini276 – 368SRCR 3PROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Contains 3 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3D. Eukaryota.
ENOG4111C54. LUCA.
GeneTreeiENSGT00390000017536.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP06127.
KOiK06455.
OMAiMSFHRNH.
OrthoDBiEOG091G0G5S.
PhylomeDBiP06127.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 2 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 2 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV
60 70 80 90 100
YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT
110 120 130 140 150
PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT
160 170 180 190 200
PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL
210 220 230 240 250
CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC
260 270 280 290 300
FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL
310 320 330 340 350
CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC
360 370 380 390 400
HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL
410 420 430 440 450
AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD
460 470 480 490
NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL
Length:495
Mass (Da):54,578
Last modified:November 30, 2010 - v2
Checksum:i9131AEC9683EE1D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289V → E in BAF85387 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020411224P → L.1 PublicationCorresponds to variant rs2241002dbSNPEnsembl.1
Natural variantiVAR_024649461H → R.Combined sources5 PublicationsCorresponds to variant rs637186dbSNPEnsembl.1
Natural variantiVAR_058203471A → V.4 PublicationsCorresponds to variant rs2229177dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04391 mRNA. Translation: CAA27979.1.
X89405
, AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA. Translation: CAA61584.2.
EF064752 Genomic DNA. Translation: ABK41935.1.
AK292698 mRNA. Translation: BAF85387.1.
AP000437 Genomic DNA. No translation available.
BC027901 mRNA. Translation: AAH27901.1.
CCDSiCCDS8000.1.
PIRiA26396.
RefSeqiNP_055022.2. NM_014207.3.
UniGeneiHs.58685.

Genome annotation databases

EnsembliENST00000347785; ENSP00000342681; ENSG00000110448.
GeneIDi921.
KEGGihsa:921.
UCSCiuc009ynk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04391 mRNA. Translation: CAA27979.1.
X89405
, AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA. Translation: CAA61584.2.
EF064752 Genomic DNA. Translation: ABK41935.1.
AK292698 mRNA. Translation: BAF85387.1.
AP000437 Genomic DNA. No translation available.
BC027901 mRNA. Translation: AAH27901.1.
CCDSiCCDS8000.1.
PIRiA26396.
RefSeqiNP_055022.2. NM_014207.3.
UniGeneiHs.58685.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JA4X-ray2.21A270-369[»]
2JOPNMR-A25-134[»]
2JP0NMR-A25-134[»]
2OTTX-ray2.50X/Y276-368[»]
ProteinModelPortaliP06127.
SMRiP06127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107359. 14 interactors.
DIPiDIP-21N.
IntActiP06127. 3 interactors.
MINTiMINT-4656212.
STRINGi9606.ENSP00000342681.

PTM databases

iPTMnetiP06127.
PhosphoSitePlusiP06127.
SwissPalmiP06127.
UniCarbKBiP06127.

Polymorphism and mutation databases

BioMutaiCD5.
DMDMi313104090.

Proteomic databases

MaxQBiP06127.
PaxDbiP06127.
PeptideAtlasiP06127.
PRIDEiP06127.

Protocols and materials databases

DNASUi921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347785; ENSP00000342681; ENSG00000110448.
GeneIDi921.
KEGGihsa:921.
UCSCiuc009ynk.4. human.

Organism-specific databases

CTDi921.
DisGeNETi921.
GeneCardsiCD5.
H-InvDBHIX0009680.
HGNCiHGNC:1685. CD5.
HPAiCAB015392.
CAB020308.
HPA043416.
HPA060839.
MIMi153340. gene.
neXtProtiNX_P06127.
OpenTargetsiENSG00000110448.
PharmGKBiPA26224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3D. Eukaryota.
ENOG4111C54. LUCA.
GeneTreeiENSGT00390000017536.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP06127.
KOiK06455.
OMAiMSFHRNH.
OrthoDBiEOG091G0G5S.
PhylomeDBiP06127.
TreeFamiTF329295.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110448-MONOMER.
SIGNORiP06127.

Miscellaneous databases

EvolutionaryTraceiP06127.
GeneWikiiCD5_(protein).
GenomeRNAii921.
PROiP06127.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110448.
CleanExiHS_CD5.
ExpressionAtlasiP06127. baseline and differential.
GenevisibleiP06127. HS.

Family and domain databases

Gene3Di3.10.250.10. 2 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 2 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD5_HUMAN
AccessioniPrimary (citable) accession number: P06127
Secondary accession number(s): A0N0P4, A8K9I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.