Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P06126

- CD1A_HUMAN

UniProt

P06126 - CD1A_HUMAN

Protein

T-cell surface glycoprotein CD1a

Gene

CD1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 4 (09 Feb 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei171 – 1711Glycolipid

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. antigen processing and presentation Source: InterPro
    2. immune response Source: UniProtKB

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell surface glycoprotein CD1a
    Alternative name(s):
    T-cell surface antigen T6/Leu-6
    Short name:
    hTa1 thymocyte antigen
    CD_antigen: CD1a
    Gene namesi
    Name:CD1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1634. CD1A.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Endosome membrane
    Note: Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26193.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Add
    BLAST
    Chaini17 – 327311T-cell surface glycoprotein CD1aPRO_0000014578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)2 Publications
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)2 Publications
    Disulfide bondi119 ↔ 183PROSITE-ProRule annotation
    Glycosylationi145 – 1451N-linked (GlcNAc...)2 Publications
    Disulfide bondi223 ↔ 2782 PublicationsPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP06126.
    PaxDbiP06126.
    PRIDEiP06126.

    Expressioni

    Tissue specificityi

    Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.2 Publications

    Gene expression databases

    BgeeiP06126.
    CleanExiHS_CD1A.
    GenevestigatoriP06126.

    Organism-specific databases

    HPAiCAB000009.
    HPA010734.

    Interactioni

    Subunit structurei

    Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    B2MP617692EBI-1036766,EBI-714718

    Protein-protein interaction databases

    BioGridi107347. 5 interactions.
    IntActiP06126. 4 interactions.
    MINTiMINT-4655994.
    STRINGi9606.ENSP00000289429.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 3713
    Beta strandi40 – 4910
    Beta strandi52 – 587
    Turni59 – 624
    Beta strandi63 – 686
    Turni69 – 746
    Helixi77 – 10529
    Beta strandi109 – 12214
    Beta strandi125 – 13511
    Beta strandi138 – 1447
    Beta strandi147 – 1504
    Helixi152 – 1543
    Helixi156 – 16510
    Helixi169 – 18012
    Helixi182 – 19312
    Helixi195 – 1984
    Beta strandi205 – 2117
    Beta strandi218 – 23114
    Beta strandi234 – 2396
    Beta strandi260 – 26910
    Helixi270 – 2723
    Beta strandi276 – 2816
    Helixi283 – 2853
    Beta strandi290 – 2934

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ONQX-ray2.15A/C18-294[»]
    1XZ0X-ray2.80A/C18-294[»]
    ProteinModelPortaliP06126.
    SMRiP06126. Positions 24-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP06126.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 300284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 3276CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini184 – 291108Ig-likeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni90 – 945Glycolipid binding

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26626.
    HOGENOMiHOG000111666.
    HOVERGENiHBG004453.
    InParanoidiP06126.
    KOiK06448.
    OMAiDFVSFQN.
    OrthoDBiEOG7DZ8K9.
    PhylomeDBiP06126.
    TreeFamiTF336723.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06126-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS    50
    DLQTHTWDSN SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR 100
    YAHELQFEYP FEIQVTGGCE LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP 150
    YPVAGNMAKH FCKVLNQNQH ENDITHNLLS DTCPRFILGL LDAGKAHLQR 200
    QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG EQEQQGTQRG 250
    DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 300
    GFIILAVIVP LLLLIGLALW FRKRCFC 327
    Length:327
    Mass (Da):37,077
    Last modified:February 9, 2010 - v4
    Checksum:iC575C3C538F0AA29
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 712WS → V in AAA51933. (PubMed:2784820)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221K → N.
    Corresponds to variant rs3087217 [ dbSNP | Ensembl ].
    VAR_062522
    Natural varianti30 – 301T → I.2 Publications
    Corresponds to variant rs2269714 [ dbSNP | Ensembl ].
    VAR_010209
    Natural varianti68 – 681C → W.2 Publications
    Corresponds to variant rs2269715 [ dbSNP | Ensembl ].
    VAR_010210

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28825 mRNA. Translation: AAA51931.1.
    M22167
    , M22080, M22163, M22164, M22165, M22166 Genomic DNA. Translation: AAA51932.1.
    AK312945 mRNA. Translation: BAG35786.1.
    AL121986 Genomic DNA. Translation: CAI10848.1.
    CH471121 Genomic DNA. Translation: EAW52843.1.
    CH471121 Genomic DNA. Translation: EAW52844.1.
    AF142665 Genomic DNA. Translation: AAD37578.1.
    M27735 mRNA. Translation: AAA51933.1.
    X04450 mRNA. Translation: CAA28049.1.
    M14663 Genomic DNA. Translation: AAA51934.1.
    CCDSiCCDS1174.1.
    PIRiA39957. HLHUCD.
    RefSeqiNP_001754.2. NM_001763.2.
    UniGeneiHs.1309.

    Genome annotation databases

    EnsembliENST00000289429; ENSP00000289429; ENSG00000158477.
    GeneIDi909.
    KEGGihsa:909.
    UCSCiuc001frt.3. human.

    Polymorphism databases

    DMDMi288558852.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28825 mRNA. Translation: AAA51931.1 .
    M22167
    , M22080 , M22163 , M22164 , M22165 , M22166 Genomic DNA. Translation: AAA51932.1 .
    AK312945 mRNA. Translation: BAG35786.1 .
    AL121986 Genomic DNA. Translation: CAI10848.1 .
    CH471121 Genomic DNA. Translation: EAW52843.1 .
    CH471121 Genomic DNA. Translation: EAW52844.1 .
    AF142665 Genomic DNA. Translation: AAD37578.1 .
    M27735 mRNA. Translation: AAA51933.1 .
    X04450 mRNA. Translation: CAA28049.1 .
    M14663 Genomic DNA. Translation: AAA51934.1 .
    CCDSi CCDS1174.1.
    PIRi A39957. HLHUCD.
    RefSeqi NP_001754.2. NM_001763.2.
    UniGenei Hs.1309.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ONQ X-ray 2.15 A/C 18-294 [» ]
    1XZ0 X-ray 2.80 A/C 18-294 [» ]
    ProteinModelPortali P06126.
    SMRi P06126. Positions 24-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107347. 5 interactions.
    IntActi P06126. 4 interactions.
    MINTi MINT-4655994.
    STRINGi 9606.ENSP00000289429.

    Chemistry

    DrugBanki DB00098. Antithymocyte globulin.

    Polymorphism databases

    DMDMi 288558852.

    Proteomic databases

    MaxQBi P06126.
    PaxDbi P06126.
    PRIDEi P06126.

    Protocols and materials databases

    DNASUi 909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289429 ; ENSP00000289429 ; ENSG00000158477 .
    GeneIDi 909.
    KEGGi hsa:909.
    UCSCi uc001frt.3. human.

    Organism-specific databases

    CTDi 909.
    GeneCardsi GC01P158224.
    H-InvDB HIX0001190.
    HGNCi HGNC:1634. CD1A.
    HPAi CAB000009.
    HPA010734.
    MIMi 188370. gene.
    neXtProti NX_P06126.
    PharmGKBi PA26193.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26626.
    HOGENOMi HOG000111666.
    HOVERGENi HBG004453.
    InParanoidi P06126.
    KOi K06448.
    OMAi DFVSFQN.
    OrthoDBi EOG7DZ8K9.
    PhylomeDBi P06126.
    TreeFami TF336723.

    Miscellaneous databases

    EvolutionaryTracei P06126.
    GeneWikii CD1A.
    GenomeRNAii 909.
    NextBioi 3750.
    PROi P06126.
    SOURCEi Search...

    Gene expression databases

    Bgeei P06126.
    CleanExi HS_CD1A.
    Genevestigatori P06126.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
      Aruffo A., Seed B.
      J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-30 AND TRP-68.
    2. "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
      Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
      Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-108.
    7. "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules."
      Longley J., Kraus J., Alonso M., Edelson R.
      J. Invest. Dermatol. 92:628-631(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-327.
    8. "A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6."
      Calabi F., Milstein C.
      Nature 323:540-543(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-327.
      Tissue: T-cell.
    9. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
      Martin L.H., Calabi F., Milstein C.
      Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-294.
    10. "CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells."
      Salamero J., Bausinger H., Mommaas A.M., Lipsker D., Proamer F., Cazenave J.-P., Goud B., de la Salle H., Hanau D.
      J. Invest. Dermatol. 116:401-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. "CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens."
      Vincent M.S., Xiong X., Grant E.P., Peng W., Brenner M.B.
      J. Immunol. 175:6344-6351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts."
      Sloma I., Zilber M.-T., Vasselon T., Setterblad N., Cavallari M., Mori L., De Libero G., Charron D., Mooney N., Gelin C.
      J. Immunol. 180:980-987(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CD47, TISSUE SPECIFICITY.
    13. "Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A."
      Zajonc D.M., Elsliger M.-A., Teyton L., Wilson I.A.
      Nat. Immunol. 4:808-815(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 18-300 IN COMPLEX WITH B2M AND SULFATIDE SELF-ANTIGEN, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
    14. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 18-294 IN COMPLEX WITH B2M AND LIPOPEPTIDE, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
    15. Cited for: VARIANTS ILE-30 AND TRP-68, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCD1A_HUMAN
    AccessioniPrimary (citable) accession number: P06126
    Secondary accession number(s): D3DVD7
    , Q13962, Q5TDJ8, Q9UMM4, Q9Y5M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 144 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3