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Protein

T-cell surface glycoprotein CD1a

Gene

CD1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171GlycolipidCombined sources1 Publication1
Binding sitei175GlycolipidCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158477-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1a
Alternative name(s):
T-cell surface antigen T6/Leu-6
Short name:
hTa1 thymocyte antigen
CD_antigen: CD1a
Gene namesi
Name:CD1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1634. CD1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 300ExtracellularSequence analysisAdd BLAST284
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 327CytoplasmicSequence analysis6

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • membrane raft Source: UniProtKB-SubCell
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi909.
OpenTargetsiENSG00000158477.
PharmGKBiPA26193.

Chemistry databases

DrugBankiDB00098. Anti-thymocyte Globulin (Rabbit).

Polymorphism and mutation databases

BioMutaiCD1A.
DMDMi288558852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000001457817 – 327T-cell surface glycoprotein CD1aAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)2 Publications1
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)3 Publications1
Disulfide bondi119 ↔ 183Combined sources1 Publication
Glycosylationi145N-linked (GlcNAc...)3 Publications1
Disulfide bondi223 ↔ 278Combined sources3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06126.
PaxDbiP06126.
PeptideAtlasiP06126.
PRIDEiP06126.

PTM databases

iPTMnetiP06126.
PhosphoSitePlusiP06126.
SwissPalmiP06126.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.2 Publications

Gene expression databases

BgeeiENSG00000158477.
CleanExiHS_CD1A.
GenevisibleiP06126. HS.

Organism-specific databases

HPAiCAB000009.
HPA010734.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2MP617692EBI-1036766,EBI-714718

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107347. 4 interactors.
IntActiP06126. 4 interactors.
MINTiMINT-4655994.
STRINGi9606.ENSP00000289429.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 37Combined sources11
Beta strandi40 – 49Combined sources10
Beta strandi52 – 58Combined sources7
Turni59 – 62Combined sources4
Beta strandi63 – 68Combined sources6
Helixi69 – 72Combined sources4
Helixi77 – 101Combined sources25
Turni102 – 106Combined sources5
Beta strandi109 – 119Combined sources11
Beta strandi129 – 135Combined sources7
Beta strandi138 – 144Combined sources7
Beta strandi147 – 150Combined sources4
Helixi152 – 154Combined sources3
Helixi155 – 165Combined sources11
Helixi169 – 180Combined sources12
Helixi182 – 191Combined sources10
Turni192 – 194Combined sources3
Helixi195 – 198Combined sources4
Beta strandi205 – 210Combined sources6
Beta strandi218 – 231Combined sources14
Beta strandi234 – 239Combined sources6
Beta strandi248 – 254Combined sources7
Beta strandi260 – 269Combined sources10
Helixi270 – 272Combined sources3
Beta strandi276 – 281Combined sources6
Helixi283 – 285Combined sources3
Beta strandi290 – 294Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ONQX-ray2.15A/C18-294[»]
1XZ0X-ray2.80A/C18-294[»]
4X6CX-ray2.80A/C21-295[»]
4X6DX-ray2.98A/C21-295[»]
4X6EX-ray2.10A21-295[»]
4X6FX-ray1.91A21-295[»]
5J1AX-ray1.86A1-295[»]
ProteinModelPortaliP06126.
SMRiP06126.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 291Ig-likeAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 94Glycolipid bindingCombined sources1 Publication5

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP06126.
KOiK06448.
OMAiNDITHNL.
OrthoDBiEOG091G0DB3.
PhylomeDBiP06126.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS
60 70 80 90 100
DLQTHTWDSN SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR
110 120 130 140 150
YAHELQFEYP FEIQVTGGCE LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP
160 170 180 190 200
YPVAGNMAKH FCKVLNQNQH ENDITHNLLS DTCPRFILGL LDAGKAHLQR
210 220 230 240 250
QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG EQEQQGTQRG
260 270 280 290 300
DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV
310 320
GFIILAVIVP LLLLIGLALW FRKRCFC
Length:327
Mass (Da):37,077
Last modified:February 9, 2010 - v4
Checksum:iC575C3C538F0AA29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70 – 71WS → V in AAA51933 (PubMed:2784820).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06252222K → N.Corresponds to variant rs3087217dbSNPEnsembl.1
Natural variantiVAR_01020930T → I.2 PublicationsCorresponds to variant rs2269714dbSNPEnsembl.1
Natural variantiVAR_01021068C → W.2 PublicationsCorresponds to variant rs2269715dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28825 mRNA. Translation: AAA51931.1.
M22167
, M22080, M22163, M22164, M22165, M22166 Genomic DNA. Translation: AAA51932.1.
AK312945 mRNA. Translation: BAG35786.1.
AL121986 Genomic DNA. Translation: CAI10848.1.
CH471121 Genomic DNA. Translation: EAW52843.1.
CH471121 Genomic DNA. Translation: EAW52844.1.
AF142665 Genomic DNA. Translation: AAD37578.1.
M27735 mRNA. Translation: AAA51933.1.
X04450 mRNA. Translation: CAA28049.1.
M14663 Genomic DNA. Translation: AAA51934.1.
CCDSiCCDS1174.1.
PIRiA39957. HLHUCD.
RefSeqiNP_001307581.1. NM_001320652.1.
NP_001754.2. NM_001763.2.
UniGeneiHs.1309.

Genome annotation databases

EnsembliENST00000289429; ENSP00000289429; ENSG00000158477.
GeneIDi909.
KEGGihsa:909.
UCSCiuc001frt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28825 mRNA. Translation: AAA51931.1.
M22167
, M22080, M22163, M22164, M22165, M22166 Genomic DNA. Translation: AAA51932.1.
AK312945 mRNA. Translation: BAG35786.1.
AL121986 Genomic DNA. Translation: CAI10848.1.
CH471121 Genomic DNA. Translation: EAW52843.1.
CH471121 Genomic DNA. Translation: EAW52844.1.
AF142665 Genomic DNA. Translation: AAD37578.1.
M27735 mRNA. Translation: AAA51933.1.
X04450 mRNA. Translation: CAA28049.1.
M14663 Genomic DNA. Translation: AAA51934.1.
CCDSiCCDS1174.1.
PIRiA39957. HLHUCD.
RefSeqiNP_001307581.1. NM_001320652.1.
NP_001754.2. NM_001763.2.
UniGeneiHs.1309.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ONQX-ray2.15A/C18-294[»]
1XZ0X-ray2.80A/C18-294[»]
4X6CX-ray2.80A/C21-295[»]
4X6DX-ray2.98A/C21-295[»]
4X6EX-ray2.10A21-295[»]
4X6FX-ray1.91A21-295[»]
5J1AX-ray1.86A1-295[»]
ProteinModelPortaliP06126.
SMRiP06126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107347. 4 interactors.
IntActiP06126. 4 interactors.
MINTiMINT-4655994.
STRINGi9606.ENSP00000289429.

Chemistry databases

DrugBankiDB00098. Anti-thymocyte Globulin (Rabbit).

PTM databases

iPTMnetiP06126.
PhosphoSitePlusiP06126.
SwissPalmiP06126.

Polymorphism and mutation databases

BioMutaiCD1A.
DMDMi288558852.

Proteomic databases

MaxQBiP06126.
PaxDbiP06126.
PeptideAtlasiP06126.
PRIDEiP06126.

Protocols and materials databases

DNASUi909.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289429; ENSP00000289429; ENSG00000158477.
GeneIDi909.
KEGGihsa:909.
UCSCiuc001frt.4. human.

Organism-specific databases

CTDi909.
DisGeNETi909.
GeneCardsiCD1A.
H-InvDBHIX0001190.
HGNCiHGNC:1634. CD1A.
HPAiCAB000009.
HPA010734.
MIMi188370. gene.
neXtProtiNX_P06126.
OpenTargetsiENSG00000158477.
PharmGKBiPA26193.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP06126.
KOiK06448.
OMAiNDITHNL.
OrthoDBiEOG091G0DB3.
PhylomeDBiP06126.
TreeFamiTF336723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158477-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP06126.
GeneWikiiCD1A.
GenomeRNAii909.
PROiP06126.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158477.
CleanExiHS_CD1A.
GenevisibleiP06126. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD1A_HUMAN
AccessioniPrimary (citable) accession number: P06126
Secondary accession number(s): D3DVD7
, Q13962, Q5TDJ8, Q9UMM4, Q9Y5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 9, 2010
Last modified: November 30, 2016
This is version 164 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.