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P06126

- CD1A_HUMAN

UniProt

P06126 - CD1A_HUMAN

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Protein

T-cell surface glycoprotein CD1a

Gene
CD1A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711Glycolipid

GO - Molecular functioni

  1. beta-2-microglobulin binding Source: RefGenome
  2. endogenous lipid antigen binding Source: RefGenome
  3. exogenous lipid antigen binding Source: RefGenome
  4. lipopeptide binding Source: RefGenome
  5. protein binding Source: IntAct

GO - Biological processi

  1. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: RefGenome
  2. immune response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1a
Alternative name(s):
T-cell surface antigen T6/Leu-6
Short name:
hTa1 thymocyte antigen
CD_antigen: CD1a
Gene namesi
Name:CD1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1634. CD1A.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endosome membrane
Note: Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 300284Extracellular Reviewed predictionAdd
BLAST
Transmembranei301 – 32121Helical; Reviewed predictionAdd
BLAST
Topological domaini322 – 3276Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 327311T-cell surface glycoprotein CD1aPRO_0000014578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)2 Publications
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...)2 Publications
Disulfide bondi119 ↔ 183 By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)2 Publications
Disulfide bondi223 ↔ 2782 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06126.
PaxDbiP06126.
PRIDEiP06126.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.2 Publications

Gene expression databases

BgeeiP06126.
CleanExiHS_CD1A.
GenevestigatoriP06126.

Organism-specific databases

HPAiCAB000009.
HPA010734.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
B2MP617692EBI-1036766,EBI-714718

Protein-protein interaction databases

BioGridi107347. 5 interactions.
IntActiP06126. 4 interactions.
MINTiMINT-4655994.
STRINGi9606.ENSP00000289429.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 3713
Beta strandi40 – 4910
Beta strandi52 – 587
Turni59 – 624
Beta strandi63 – 686
Turni69 – 746
Helixi77 – 10529
Beta strandi109 – 12214
Beta strandi125 – 13511
Beta strandi138 – 1447
Beta strandi147 – 1504
Helixi152 – 1543
Helixi156 – 16510
Helixi169 – 18012
Helixi182 – 19312
Helixi195 – 1984
Beta strandi205 – 2117
Beta strandi218 – 23114
Beta strandi234 – 2396
Beta strandi260 – 26910
Helixi270 – 2723
Beta strandi276 – 2816
Helixi283 – 2853
Beta strandi290 – 2934

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ONQX-ray2.15A/C18-294[»]
1XZ0X-ray2.80A/C18-294[»]
ProteinModelPortaliP06126.
SMRiP06126. Positions 24-294.

Miscellaneous databases

EvolutionaryTraceiP06126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 291108Ig-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni90 – 945Glycolipid binding

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26626.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP06126.
KOiK06448.
OMAiDFVSFQN.
OrthoDBiEOG7DZ8K9.
PhylomeDBiP06126.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06126-1 [UniParc]FASTAAdd to Basket

« Hide

MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS    50
DLQTHTWDSN SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR 100
YAHELQFEYP FEIQVTGGCE LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP 150
YPVAGNMAKH FCKVLNQNQH ENDITHNLLS DTCPRFILGL LDAGKAHLQR 200
QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG EQEQQGTQRG 250
DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 300
GFIILAVIVP LLLLIGLALW FRKRCFC 327
Length:327
Mass (Da):37,077
Last modified:February 9, 2010 - v4
Checksum:iC575C3C538F0AA29
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221K → N.
Corresponds to variant rs3087217 [ dbSNP | Ensembl ].
VAR_062522
Natural varianti30 – 301T → I.2 Publications
Corresponds to variant rs2269714 [ dbSNP | Ensembl ].
VAR_010209
Natural varianti68 – 681C → W.2 Publications
Corresponds to variant rs2269715 [ dbSNP | Ensembl ].
VAR_010210

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 712WS → V in AAA51933. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28825 mRNA. Translation: AAA51931.1.
M22167
, M22080, M22163, M22164, M22165, M22166 Genomic DNA. Translation: AAA51932.1.
AK312945 mRNA. Translation: BAG35786.1.
AL121986 Genomic DNA. Translation: CAI10848.1.
CH471121 Genomic DNA. Translation: EAW52843.1.
CH471121 Genomic DNA. Translation: EAW52844.1.
AF142665 Genomic DNA. Translation: AAD37578.1.
M27735 mRNA. Translation: AAA51933.1.
X04450 mRNA. Translation: CAA28049.1.
M14663 Genomic DNA. Translation: AAA51934.1.
CCDSiCCDS1174.1.
PIRiA39957. HLHUCD.
RefSeqiNP_001754.2. NM_001763.2.
UniGeneiHs.1309.

Genome annotation databases

EnsembliENST00000289429; ENSP00000289429; ENSG00000158477.
GeneIDi909.
KEGGihsa:909.
UCSCiuc001frt.3. human.

Polymorphism databases

DMDMi288558852.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28825 mRNA. Translation: AAA51931.1 .
M22167
, M22080 , M22163 , M22164 , M22165 , M22166 Genomic DNA. Translation: AAA51932.1 .
AK312945 mRNA. Translation: BAG35786.1 .
AL121986 Genomic DNA. Translation: CAI10848.1 .
CH471121 Genomic DNA. Translation: EAW52843.1 .
CH471121 Genomic DNA. Translation: EAW52844.1 .
AF142665 Genomic DNA. Translation: AAD37578.1 .
M27735 mRNA. Translation: AAA51933.1 .
X04450 mRNA. Translation: CAA28049.1 .
M14663 Genomic DNA. Translation: AAA51934.1 .
CCDSi CCDS1174.1.
PIRi A39957. HLHUCD.
RefSeqi NP_001754.2. NM_001763.2.
UniGenei Hs.1309.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ONQ X-ray 2.15 A/C 18-294 [» ]
1XZ0 X-ray 2.80 A/C 18-294 [» ]
ProteinModelPortali P06126.
SMRi P06126. Positions 24-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107347. 5 interactions.
IntActi P06126. 4 interactions.
MINTi MINT-4655994.
STRINGi 9606.ENSP00000289429.

Chemistry

DrugBanki DB00098. Antithymocyte globulin.

Polymorphism databases

DMDMi 288558852.

Proteomic databases

MaxQBi P06126.
PaxDbi P06126.
PRIDEi P06126.

Protocols and materials databases

DNASUi 909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289429 ; ENSP00000289429 ; ENSG00000158477 .
GeneIDi 909.
KEGGi hsa:909.
UCSCi uc001frt.3. human.

Organism-specific databases

CTDi 909.
GeneCardsi GC01P158224.
H-InvDB HIX0001190.
HGNCi HGNC:1634. CD1A.
HPAi CAB000009.
HPA010734.
MIMi 188370. gene.
neXtProti NX_P06126.
PharmGKBi PA26193.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26626.
HOGENOMi HOG000111666.
HOVERGENi HBG004453.
InParanoidi P06126.
KOi K06448.
OMAi DFVSFQN.
OrthoDBi EOG7DZ8K9.
PhylomeDBi P06126.
TreeFami TF336723.

Miscellaneous databases

EvolutionaryTracei P06126.
GeneWikii CD1A.
GenomeRNAii 909.
NextBioi 3750.
PROi P06126.
SOURCEi Search...

Gene expression databases

Bgeei P06126.
CleanExi HS_CD1A.
Genevestigatori P06126.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
    Aruffo A., Seed B.
    J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-30 AND TRP-68.
  2. "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
    Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
    Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-108.
  7. "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules."
    Longley J., Kraus J., Alonso M., Edelson R.
    J. Invest. Dermatol. 92:628-631(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-327.
  8. "A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6."
    Calabi F., Milstein C.
    Nature 323:540-543(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-327.
    Tissue: T-cell.
  9. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
    Martin L.H., Calabi F., Milstein C.
    Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-294.
  10. "CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells."
    Salamero J., Bausinger H., Mommaas A.M., Lipsker D., Proamer F., Cazenave J.-P., Goud B., de la Salle H., Hanau D.
    J. Invest. Dermatol. 116:401-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens."
    Vincent M.S., Xiong X., Grant E.P., Peng W., Brenner M.B.
    J. Immunol. 175:6344-6351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts."
    Sloma I., Zilber M.-T., Vasselon T., Setterblad N., Cavallari M., Mori L., De Libero G., Charron D., Mooney N., Gelin C.
    J. Immunol. 180:980-987(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CD47, TISSUE SPECIFICITY.
  13. "Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A."
    Zajonc D.M., Elsliger M.-A., Teyton L., Wilson I.A.
    Nat. Immunol. 4:808-815(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 18-300 IN COMPLEX WITH B2M AND SULFATIDE SELF-ANTIGEN, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
  14. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 18-294 IN COMPLEX WITH B2M AND LIPOPEPTIDE, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
  15. Cited for: VARIANTS ILE-30 AND TRP-68, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCD1A_HUMAN
AccessioniPrimary (citable) accession number: P06126
Secondary accession number(s): D3DVD7
, Q13962, Q5TDJ8, Q9UMM4, Q9Y5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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