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P06126 (CD1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell surface glycoprotein CD1a
Alternative name(s):
T-cell surface antigen T6/Leu-6
Short name=hTa1 thymocyte antigen
CD_antigen=CD1a
Gene names
Name:CD1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Ref.10 Ref.11 Ref.12

Subunit structure

Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74. Ref.12

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts. Ref.10 Ref.12 Ref.15

Tissue specificity

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. Ref.10 Ref.12

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

B2MP617692EBI-1036766,EBI-714718

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616
Chain17 – 327311T-cell surface glycoprotein CD1a
PRO_0000014578

Regions

Topological domain17 – 300284Extracellular Potential
Transmembrane301 – 32121Helical; Potential
Topological domain322 – 3276Cytoplasmic Potential
Domain184 – 291108Ig-like
Region90 – 945Glycolipid binding

Sites

Binding site1711Glycolipid

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Ref.13 Ref.14
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Ref.13 Ref.14
Glycosylation1451N-linked (GlcNAc...) Ref.13 Ref.14
Disulfide bond119 ↔ 183 By similarity
Disulfide bond223 ↔ 278 Ref.13 Ref.14

Natural variations

Natural variant221K → N.
Corresponds to variant rs3087217 [ dbSNP | Ensembl ].
VAR_062522
Natural variant301T → I. Ref.1 Ref.15
Corresponds to variant rs2269714 [ dbSNP | Ensembl ].
VAR_010209
Natural variant681C → W. Ref.1 Ref.15
Corresponds to variant rs2269715 [ dbSNP | Ensembl ].
VAR_010210

Experimental info

Sequence conflict70 – 712WS → V in AAA51933. Ref.7

Secondary structure

............................................. 327
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P06126 [UniParc].

Last modified February 9, 2010. Version 4.
Checksum: C575C3C538F0AA29

FASTA32737,077
        10         20         30         40         50         60 
MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS DLQTHTWDSN 

        70         80         90        100        110        120 
SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR YAHELQFEYP FEIQVTGGCE 

       130        140        150        160        170        180 
LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP YPVAGNMAKH FCKVLNQNQH ENDITHNLLS 

       190        200        210        220        230        240 
DTCPRFILGL LDAGKAHLQR QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG 

       250        260        270        280        290        300 
EQEQQGTQRG DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 

       310        320 
GFIILAVIVP LLLLIGLALW FRKRCFC 

« Hide

References

« Hide 'large scale' references
[1]"Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
Aruffo A., Seed B.
J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-30 AND TRP-68.
[2]"Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Polymorphism of human CD1 genes."
Han M., Hannick L.I., DiBrino M., Robinson M.A.
Tissue Antigens 54:122-127(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-108.
[7]"Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules."
Longley J., Kraus J., Alonso M., Edelson R.
J. Invest. Dermatol. 92:628-631(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-327.
[8]"A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6."
Calabi F., Milstein C.
Nature 323:540-543(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-327.
Tissue: T-cell.
[9]"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
Martin L.H., Calabi F., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-294.
[10]"CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells."
Salamero J., Bausinger H., Mommaas A.M., Lipsker D., Proamer F., Cazenave J.-P., Goud B., de la Salle H., Hanau D.
J. Invest. Dermatol. 116:401-408(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]"CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens."
Vincent M.S., Xiong X., Grant E.P., Peng W., Brenner M.B.
J. Immunol. 175:6344-6351(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts."
Sloma I., Zilber M.-T., Vasselon T., Setterblad N., Cavallari M., Mori L., De Libero G., Charron D., Mooney N., Gelin C.
J. Immunol. 180:980-987(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CD47, TISSUE SPECIFICITY.
[13]"Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A."
Zajonc D.M., Elsliger M.-A., Teyton L., Wilson I.A.
Nat. Immunol. 4:808-815(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 18-300 IN COMPLEX WITH B2M AND SULFATIDE SELF-ANTIGEN, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
[14]"Molecular mechanism of lipopeptide presentation by CD1a."
Zajonc D.M., Crispin M.D., Bowden T.A., Young D.C., Cheng T.-Y., Hu J., Costello C.E., Rudd P.M., Dwek R.A., Miller M.J., Brenner M.B., Moody D.B., Wilson I.A.
Immunity 22:209-219(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 18-294 IN COMPLEX WITH B2M AND LIPOPEPTIDE, GLYCOSYLATION AT ASN-37; ASN-74 AND ASN-145, DISULFIDE BOND.
[15]"Structural characterization of two CD1A allelic variants."
Oteo M., Arribas P., Setien F., Parra J.F., Mirones I., Gomez del Moral M., Martinez-Naves E.
Hum. Immunol. 62:1137-1141(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ILE-30 AND TRP-68, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M28825 mRNA. Translation: AAA51931.1.
M22167 expand/collapse EMBL AC list , M22080, M22163, M22164, M22165, M22166 Genomic DNA. Translation: AAA51932.1.
AK312945 mRNA. Translation: BAG35786.1.
AL121986 Genomic DNA. Translation: CAI10848.1.
CH471121 Genomic DNA. Translation: EAW52843.1.
CH471121 Genomic DNA. Translation: EAW52844.1.
AF142665 Genomic DNA. Translation: AAD37578.1.
M27735 mRNA. Translation: AAA51933.1.
X04450 mRNA. Translation: CAA28049.1.
M14663 Genomic DNA. Translation: AAA51934.1.
CCDSCCDS1174.1.
PIRHLHUCD. A39957.
RefSeqNP_001754.2. NM_001763.2.
UniGeneHs.1309.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ONQX-ray2.15A/C18-294[»]
1XZ0X-ray2.80A/C18-294[»]
ProteinModelPortalP06126.
SMRP06126. Positions 24-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107347. 5 interactions.
IntActP06126. 4 interactions.
MINTMINT-4655994.
STRING9606.ENSP00000289429.

Chemistry

DrugBankDB00098. Antithymocyte globulin.

Polymorphism databases

DMDM288558852.

Proteomic databases

MaxQBP06126.
PaxDbP06126.
PRIDEP06126.

Protocols and materials databases

DNASU909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289429; ENSP00000289429; ENSG00000158477.
GeneID909.
KEGGhsa:909.
UCSCuc001frt.3. human.

Organism-specific databases

CTD909.
GeneCardsGC01P158224.
H-InvDBHIX0001190.
HGNCHGNC:1634. CD1A.
HPACAB000009.
HPA010734.
MIM188370. gene.
neXtProtNX_P06126.
PharmGKBPA26193.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26626.
HOGENOMHOG000111666.
HOVERGENHBG004453.
InParanoidP06126.
KOK06448.
OMADFVSFQN.
OrthoDBEOG7DZ8K9.
PhylomeDBP06126.
TreeFamTF336723.

Gene expression databases

BgeeP06126.
CleanExHS_CD1A.
GenevestigatorP06126.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP06126.
GeneWikiCD1A.
GenomeRNAi909.
NextBio3750.
PROP06126.
SOURCESearch...

Entry information

Entry nameCD1A_HUMAN
AccessionPrimary (citable) accession number: P06126
Secondary accession number(s): D3DVD7 expand/collapse secondary AC list , Q13962, Q5TDJ8, Q9UMM4, Q9Y5M5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries