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Protein

Catalase T

Gene

CTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Miscellaneous

This is one of two catalases in S.cerevisiae; the other is catalase A, which is the peroxisomal form.
Present with 319 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64PROSITE-ProRule annotation1
Active sitei137PROSITE-ProRule annotation1
Metal bindingi351Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: SGD
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • hydrogen peroxide catabolic process Source: GO_Central
  • response to hydrogen peroxide Source: GO_Central
  • response to reactive oxygen species Source: SGD

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YGR088W-MONOMER

Protein family/group databases

PeroxiBasei5176 SceKat02

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase T (EC:1.11.1.6)
Gene namesi
Name:CTT1
Ordered Locus Names:YGR088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR088W
SGDiS000003320 CTT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849291 – 562Catalase TAdd BLAST562

Proteomic databases

MaxQBiP06115
PaxDbiP06115
PRIDEiP06115

PTM databases

iPTMnetiP06115

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi33330, 59 interactors
DIPiDIP-4310N
IntActiP06115, 6 interactors
STRINGi4932.YGR088W

Structurei

3D structure databases

ProteinModelPortaliP06115
SMRiP06115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000146130
HOGENOMiHOG000087852
InParanoidiP06115
KOiK03781
OMAiPSNTCIP
OrthoDBiEOG092C0NOX

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P06115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFGKKEEK QEKVYSLQNG FPYSHHPYAS QYSRPDGPIL LQDFHLLENI
60 70 80 90 100
ASFDRERVPE RVVHAKGGGC RLEFELTDSL SDITYAAPYQ NVGYKCPGLV
110 120 130 140 150
RFSTVGGESG TPDTARDPRG VSFKFYTEWG NHDWVFNNTP VFFLRDAIKF
160 170 180 190 200
PVFIHSQKRD PQSHLNQFQD TTIYWDYLTL NPESIHQITY MFGDRGTPAS
210 220 230 240 250
WASMNAYSGH SFIMVNKEGK DTYVQFHVLS DTGFETLTGD KAAELSGSHP
260 270 280 290 300
DYNQAKLFTQ LQNGEKPKFN CYVQTMTPEQ ATKFRYSVND LTKIWPHKEF
310 320 330 340 350
PLRKFGTITL TENVDNYFQE IEQVAFSPTN TCIPGIKPSN DSVLQARLFS
360 370 380 390 400
YPDTQRHRLG ANYQQLPVNR PRNLGCPYSK GDSQYTAEQC PFKAVNFQRD
410 420 430 440 450
GPMSYYNFGP EPNYISSLPN QTLKFKNEDN DEVSDKFKGI VLDEVTEVSV
460 470 480 490 500
RKQEQDQIRN EHIVDAKINQ YYYVYGISPL DFEQPRALYE KVYNDEQKKL
510 520 530 540 550
FVHNVVCHAC KIKDPKVKKR VTQYFGLLNE DLGKVIAECL GVPWEPVDLE
560
GYAKTWSIAS AN
Length:562
Mass (Da):64,583
Last modified:April 29, 2008 - v3
Checksum:i1197842ADEAAE7D0
GO

Sequence cautioni

The sequence AAA34540 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA97090 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429D → V in CAA28298 (PubMed:3536508).Curated1
Sequence conflicti539C → G in CAA28298 (PubMed:3536508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04625 Genomic DNA Translation: CAA28298.1
Z72873 Genomic DNA Translation: CAA97090.1 Different initiation.
M30256 Genomic DNA Translation: AAA34540.1 Different initiation.
BK006941 Genomic DNA Translation: DAA08181.1
PIRiS64383 CSBYT
RefSeqiNP_011602.2, NM_001181217.1

Genome annotation databases

EnsemblFungiiYGR088W; YGR088W; YGR088W
GeneIDi852979
KEGGisce:YGR088W

Similar proteinsi

Entry informationi

Entry nameiCATT_YEAST
AccessioniPrimary (citable) accession number: P06115
Secondary accession number(s): D6VUM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health