Reviewed,
UniProtKB/Swiss-Prot P06115 (CATT_YEAST)
Last modified
February 9, 2010.
Version 101.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Catalase T EC=1.11.1.6 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 562 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. |
| Catalytic activity | 2 H2O2 = O2 + 2 H2O. |
| Cofactor | Heme group. |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Miscellaneous | This is one of two catalases in S.cerevisiae; the other is catalase A, which is the peroxisomal form. Present with 319 molecules/cell in log phase SD medium. Ref.6 |
| Sequence similarities | Belongs to the catalase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen peroxide |
| Cellular component | Cytoplasm |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Oxidoreductase Peroxidase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cellular response to water deprivation Inferred from mutant phenotype. Source: SGD hydrogen peroxide catabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Traceable author statement. Source: SGD |
| Molecular function | catalase activity Inferred from electronic annotation. Source: EC heme bindingInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| HUG1 | Q6Q5K6 | 1 | EBI-4065,EBI-392766 | |
| PGM2 | P37012 | 1 | EBI-4065,EBI-13296 | |
| RNR1 | P21524 | 1 | EBI-4065,EBI-15234 | |
| RNR2 | P09938 | 1 | EBI-4065,EBI-15240 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 562 | 562 | Catalase T | PRO_0000084929 | |||||
Sites | |||||||||
| Active site | 64 | 1 | By similarity | ||||||
| Active site | 137 | 1 | By similarity | ||||||
| Metal binding | 351 | 1 | Iron (heme axial ligand) By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 52 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 417 | 1 | Phosphoserine Ref.8 | ||||||
Experimental info | |||||||||
| Sequence conflict | 429 | 1 | D → V in CAA28298. Ref.1 | ||||||
| Sequence conflict | 539 | 1 | C → G in CAA28298. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of the Saccharomyces cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase T." Hartig A., Ruis H. Eur. J. Biochem. 160:487-490(1986) [PubMed: 3536508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K.Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [3] | "Heme control region of the catalase T gene of the yeast Saccharomyces cerevisiae." Spevak W., Hartig A., Meindl P., Ruis H. Mol. Gen. Genet. 203:73-78(1986) [PubMed: 2423850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63. |
| [4] | "Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway." Norbeck J., Blomberg A. J. Biol. Chem. 272:5544-5554(1997) [PubMed: 9038161] [Abstract] Cited for: PROTEIN SEQUENCE OF 394-398. Strain: ATCC 44827 / SKQ2N. |
| [5] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [6] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [7] | "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE." Zhang Z., Dietrich F.S. Nucleic Acids Res. 33:2838-2851(2005) [PubMed: 15905473] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE. |
| [8] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-417, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X04625 Genomic DNA. Translation: CAA28298.1. Z72873 Genomic DNA. Translation: CAA97090.1. Different initiation. M30256 Genomic DNA. Translation: AAA34540.1. Different initiation. |
| PIR | CSBYT. S64383. |
| RefSeq | NP_011602.2. |
3D structure databases | |
| SMR | P06115. Positions 9-540. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4310N. |
| IntAct | P06115. 12 interactions. |
| STRING | P06115. |
Protein family/group databases | |
| PeroxiBase | 5176. SceKat02. |
Proteomic databases | |
| PeptideAtlas | P06115. |
Genome annotation databases | |
| Ensembl | YGR088W; YGR088W; YGR088W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 852979. |
| KEGG | sce:YGR088W. |
| NMPDR | fig|4932.3.peg.2719. |
Organism-specific databases | |
| CYGD | YGR088w. |
| SGD | S000003320. CTT1. |
Phylogenomic databases | |
| eggNOG | fuNOG05162. |
| HOGENOM | HBG339355. |
| OrthoDB | EOG9QNPCB. |
| PhylomeDB | P06115. |
Enzyme and pathway databases | |
| BRENDA | 1.11.1.6. 250. |
Gene expression databases | |
| ArrayExpress | P06115. |
| Genevestigator | P06115. |
| GermOnline | YGR088W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR002226. Catalase. IPR020835. Catalase-like_haem-dep. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view] |
| Gene3D | G3DSA:2.40.180.10. Catalase_N. 1 hit. |
| PANTHER | PTHR11465. Catalase. 1 hit. |
| Pfam | PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view] |
| PRINTS | PR00067. CATALASE. |
| PROSITE | PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 972783. |
Entry information
| Entry name | CATT_YEAST | ||||||||
| Accession | Primary (citable) accession number: P06115 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Recent format changes Overview of recent format changes |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VII Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names |

Clusters with


