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Reviewed, UniProtKB/Swiss-Prot P06115 (CATT_YEAST)

Last modified February 9, 2010. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Catalase T
    EC=1.11.1.6
Gene names
Name: CTT1
Ordered Locus Names: YGR088W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm Ref.5.

Miscellaneous

This is one of two catalases in S.cerevisiae; the other is catalase A, which is the peroxisomal form.

Present with 319 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Belongs to the catalase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Catalase T
PRO_0000084929

Sites

Active site641 By similarity
Active site1371 By similarity
Metal binding3511Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue521Phosphoserine Ref.8
Modified residue4171Phosphoserine Ref.8

Experimental info

Sequence conflict4291D → V in CAA28298. Ref.1
Sequence conflict5391C → G in CAA28298. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P06115-1 [UniParc].

Last modified April 29, 2008. Version 3.
Checksum: 1197842ADEAAE7D0

FASTA56264,583
        10         20         30         40         50         60 
MNVFGKKEEK QEKVYSLQNG FPYSHHPYAS QYSRPDGPIL LQDFHLLENI ASFDRERVPE 

        70         80         90        100        110        120 
RVVHAKGGGC RLEFELTDSL SDITYAAPYQ NVGYKCPGLV RFSTVGGESG TPDTARDPRG 

       130        140        150        160        170        180 
VSFKFYTEWG NHDWVFNNTP VFFLRDAIKF PVFIHSQKRD PQSHLNQFQD TTIYWDYLTL 

       190        200        210        220        230        240 
NPESIHQITY MFGDRGTPAS WASMNAYSGH SFIMVNKEGK DTYVQFHVLS DTGFETLTGD 

       250        260        270        280        290        300 
KAAELSGSHP DYNQAKLFTQ LQNGEKPKFN CYVQTMTPEQ ATKFRYSVND LTKIWPHKEF 

       310        320        330        340        350        360 
PLRKFGTITL TENVDNYFQE IEQVAFSPTN TCIPGIKPSN DSVLQARLFS YPDTQRHRLG 

       370        380        390        400        410        420 
ANYQQLPVNR PRNLGCPYSK GDSQYTAEQC PFKAVNFQRD GPMSYYNFGP EPNYISSLPN 

       430        440        450        460        470        480 
QTLKFKNEDN DEVSDKFKGI VLDEVTEVSV RKQEQDQIRN EHIVDAKINQ YYYVYGISPL 

       490        500        510        520        530        540 
DFEQPRALYE KVYNDEQKKL FVHNVVCHAC KIKDPKVKKR VTQYFGLLNE DLGKVIAECL 

       550        560 
GVPWEPVDLE GYAKTWSIAS AN

« Hide

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Saccharomyces cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase T."
Hartig A., Ruis H.
Eur. J. Biochem. 160:487-490(1986) [PubMed: 3536508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Heme control region of the catalase T gene of the yeast Saccharomyces cerevisiae."
Spevak W., Hartig A., Meindl P., Ruis H.
Mol. Gen. Genet. 203:73-78(1986) [PubMed: 2423850] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.
[4]"Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway."
Norbeck J., Blomberg A.
J. Biol. Chem. 272:5544-5554(1997) [PubMed: 9038161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 394-398.
Strain: ATCC 44827 / SKQ2N.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
Zhang Z., Dietrich F.S.
Nucleic Acids Res. 33:2838-2851(2005) [PubMed: 15905473] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-417, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X04625 Genomic DNA. Translation: CAA28298.1.
Z72873 Genomic DNA. Translation: CAA97090.1. Different initiation.
M30256 Genomic DNA. Translation: AAA34540.1. Different initiation.
PIRCSBYT. S64383.
RefSeqNP_011602.2.

3D structure databases

SMRP06115. Positions 9-540.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4310N.
IntActP06115. 12 interactions.
STRINGP06115.

Protein family/group databases

PeroxiBase5176. SceKat02.

Proteomic databases

PeptideAtlasP06115.

Genome annotation databases

EnsemblYGR088W; YGR088W; YGR088W; Saccharomyces cerevisiae. [Genome view]
GeneID852979.
KEGGsce:YGR088W.
NMPDRfig|4932.3.peg.2719.

Organism-specific databases

CYGDYGR088w.
SGDS000003320. CTT1.

Phylogenomic databases

eggNOGfuNOG05162.
HOGENOMHBG339355.
OrthoDBEOG9QNPCB.
PhylomeDBP06115.

Enzyme and pathway databases

BRENDA1.11.1.6. 250.

Gene expression databases

ArrayExpressP06115.
GenevestigatorP06115.
GermOnlineYGR088W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002226. Catalase.
IPR020835. Catalase-like_haem-dep.
IPR010582. Catalase-rel_immune_responsive.
IPR011614. Catalase_N.
IPR018028. Catalase_rel_subgroup.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PRINTSPR00067. CATALASE.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio972783.

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Entry information

Entry nameCATT_YEAST
AccessionPrimary (citable) accession number: P06115
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 29, 2008
Last modified: February 9, 2010
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents