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Protein

Catalase T

Gene

CTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641PROSITE-ProRule annotation
Active sitei137 – 1371PROSITE-ProRule annotation
Metal bindingi351 – 3511Iron (heme axial ligand)By similarity

GO - Molecular functioni

  • catalase activity Source: SGD
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • hydrogen peroxide catabolic process Source: GO_Central
  • response to hydrogen peroxide Source: GO_Central
  • response to reactive oxygen species Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YGR088W-MONOMER.

Protein family/group databases

PeroxiBasei5176. SceKat02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase T (EC:1.11.1.6)
Gene namesi
Name:CTT1
Ordered Locus Names:YGR088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR088W.
SGDiS000003320. CTT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Catalase TPRO_0000084929Add
BLAST

Proteomic databases

MaxQBiP06115.

PTM databases

iPTMnetiP06115.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi33330. 35 interactions.
DIPiDIP-4310N.
IntActiP06115. 4 interactions.
MINTiMINT-522531.

Structurei

3D structure databases

ProteinModelPortaliP06115.
SMRiP06115. Positions 14-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

HOGENOMiHOG000087852.
InParanoidiP06115.
KOiK03781.
OMAiINCPFAQ.
OrthoDBiEOG092C0NOX.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 3 hits.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFGKKEEK QEKVYSLQNG FPYSHHPYAS QYSRPDGPIL LQDFHLLENI
60 70 80 90 100
ASFDRERVPE RVVHAKGGGC RLEFELTDSL SDITYAAPYQ NVGYKCPGLV
110 120 130 140 150
RFSTVGGESG TPDTARDPRG VSFKFYTEWG NHDWVFNNTP VFFLRDAIKF
160 170 180 190 200
PVFIHSQKRD PQSHLNQFQD TTIYWDYLTL NPESIHQITY MFGDRGTPAS
210 220 230 240 250
WASMNAYSGH SFIMVNKEGK DTYVQFHVLS DTGFETLTGD KAAELSGSHP
260 270 280 290 300
DYNQAKLFTQ LQNGEKPKFN CYVQTMTPEQ ATKFRYSVND LTKIWPHKEF
310 320 330 340 350
PLRKFGTITL TENVDNYFQE IEQVAFSPTN TCIPGIKPSN DSVLQARLFS
360 370 380 390 400
YPDTQRHRLG ANYQQLPVNR PRNLGCPYSK GDSQYTAEQC PFKAVNFQRD
410 420 430 440 450
GPMSYYNFGP EPNYISSLPN QTLKFKNEDN DEVSDKFKGI VLDEVTEVSV
460 470 480 490 500
RKQEQDQIRN EHIVDAKINQ YYYVYGISPL DFEQPRALYE KVYNDEQKKL
510 520 530 540 550
FVHNVVCHAC KIKDPKVKKR VTQYFGLLNE DLGKVIAECL GVPWEPVDLE
560
GYAKTWSIAS AN
Length:562
Mass (Da):64,583
Last modified:April 29, 2008 - v3
Checksum:i1197842ADEAAE7D0
GO

Sequence cautioni

The sequence AAA34540 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA97090 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291D → V in CAA28298 (PubMed:3536508).Curated
Sequence conflicti539 – 5391C → G in CAA28298 (PubMed:3536508).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04625 Genomic DNA. Translation: CAA28298.1.
Z72873 Genomic DNA. Translation: CAA97090.1. Different initiation.
M30256 Genomic DNA. Translation: AAA34540.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA08181.1.
PIRiS64383. CSBYT.
RefSeqiNP_011602.2. NM_001181217.1.

Genome annotation databases

EnsemblFungiiYGR088W; YGR088W; YGR088W.
GeneIDi852979.
KEGGisce:YGR088W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04625 Genomic DNA. Translation: CAA28298.1.
Z72873 Genomic DNA. Translation: CAA97090.1. Different initiation.
M30256 Genomic DNA. Translation: AAA34540.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA08181.1.
PIRiS64383. CSBYT.
RefSeqiNP_011602.2. NM_001181217.1.

3D structure databases

ProteinModelPortaliP06115.
SMRiP06115. Positions 14-540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33330. 35 interactions.
DIPiDIP-4310N.
IntActiP06115. 4 interactions.
MINTiMINT-522531.

Protein family/group databases

PeroxiBasei5176. SceKat02.

PTM databases

iPTMnetiP06115.

Proteomic databases

MaxQBiP06115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR088W; YGR088W; YGR088W.
GeneIDi852979.
KEGGisce:YGR088W.

Organism-specific databases

EuPathDBiFungiDB:YGR088W.
SGDiS000003320. CTT1.

Phylogenomic databases

HOGENOMiHOG000087852.
InParanoidiP06115.
KOiK03781.
OMAiINCPFAQ.
OrthoDBiEOG092C0NOX.

Enzyme and pathway databases

BioCyciYEAST:YGR088W-MONOMER.

Miscellaneous databases

PROiP06115.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 3 hits.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATT_YEAST
AccessioniPrimary (citable) accession number: P06115
Secondary accession number(s): D6VUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

This is one of two catalases in S.cerevisiae; the other is catalase A, which is the peroxisomal form.
Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.