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Protein

Protein SCP160

Gene

SCP160

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes.

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: SGD
  • mRNA binding Source: SGD
  • RNA binding Source: SGD

GO - Biological processi

  • chemotropism Source: SGD
  • chromatin silencing at silent mating-type cassette Source: SGD
  • chromatin silencing at telomere Source: SGD
  • chromosome segregation Source: SGD
  • intracellular mRNA localization Source: SGD
  • meiotic telomere clustering Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31537-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCP160
Alternative name(s):
Protein HX
Gene namesi
Name:SCP160
Synonyms:HX
Ordered Locus Names:YJL080C
ORF Names:J1017
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL080C
SGDiS000003616 SCP160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501281 – 1222Protein SCP160Add BLAST1222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphothreonineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06105
PaxDbiP06105
PRIDEiP06105

PTM databases

iPTMnetiP06105

Interactioni

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: SGD

Protein-protein interaction databases

BioGridi33676, 243 interactors
DIPiDIP-2742N
IntActiP06105, 47 interactors
MINTiP06105
STRINGi4932.YJL080C

Structurei

3D structure databases

ProteinModelPortaliP06105
SMRiP06105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 249KH 1PROSITE-ProRule annotationAdd BLAST73
Domaini634 – 702KH 2PROSITE-ProRule annotationAdd BLAST69
Domaini712 – 771KH 3PROSITE-ProRule annotationAdd BLAST60
Domaini782 – 851KH 4PROSITE-ProRule annotationAdd BLAST70
Domaini861 – 929KH 5PROSITE-ProRule annotationAdd BLAST69
Domaini939 – 1001KH 6PROSITE-ProRule annotationAdd BLAST63
Domaini1153 – 1216KH 7PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00900000141059
HOGENOMiHOG000246781
InParanoidiP06105
OMAiYKHIIGK
OrthoDBiEOG092C08FQ

Family and domain databases

Gene3Di3.30.1370.10, 6 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 7 hits
SMARTiView protein in SMART
SM00322 KH, 7 hits
SUPFAMiSSF54791 SSF54791, 6 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 7 hits

Sequencei

Sequence statusi: Complete.

P06105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEQTAIDS PPSTVEGSVE TVTTIDSPST TASTIAATAE EHPQLEKKPT
60 70 80 90 100
PLPSLKDLPS LGSNAAFANV KVSWGPNMKP AVSNSPSPSP SAPSLTTGLG
110 120 130 140 150
AKRMRSKNIQ EAFTLDLQSQ LSITKPELSR IVQSVKKNHD VSVESTLSKN
160 170 180 190 200
ARTFLVSGVA ANVHEAKREL VKKLTKPINA VIEVPSKCKA SIIGSGGRTI
210 220 230 240 250
REISDAYEVK INVSKEVNEN SYDEDMDDTT SNVSLFGDFE SVNLAKAKIL
260 270 280 290 300
AIVKEETKNA TIKLVVEDEK YLPYIDVSEF ASDEGDEEVK VQFYKKSGDI
310 320 330 340 350
VILGPREKAK ATKTSIQDYL KKLASNLDEE KVKIPSKFQF LIDAEELKEK
360 370 380 390 400
YNVIVTFPST PDDELVSFVG LRDKVGEAIT YARSSSKSYV VESLDISKAH
410 420 430 440 450
SKNLTHAKNL IMYFTKYSVL KGLEESHPNV KISLPSIQSL PTAETVTIHI
460 470 480 490 500
SAKSDEANDI KAVRKELISF VNNIPPSETL VITDLDYELF GGSIKHCLLA
510 520 530 540 550
SESSVAFVQF GDYYPNDNSI LLVALTEDED FKPSIEEIQA SLNKANESLN
560 570 580 590 600
SLRTKQNNME TKTYEFSEEV QDSLFKPSSA TWKLIMEDIS EQEGHLQIKL
610 620 630 640 650
HTPEENQLTV RGDEKAAKAA NKIFESILNS PSSKSKMTVN IPANSVARLI
660 670 680 690 700
GNKGSNLQQI REKFACQIDI PNEENNNASK DKTVEVTLTG LEYNLTHAKK
710 720 730 740 750
YLAAEAKKWA DIITKELIVP VKFHGSLIGP HGTYRNRLQE KYNVFINFPR
760 770 780 790 800
DNEIVTIRGP SRGVNKAHEE LKALLDFEME NGHKMVINVP AEHVPRIIGK
810 820 830 840 850
NGDNINDIRA EYGVEMDFLQ KSTDPKAQET GEVELEITGS RQNIKDAAKR
860 870 880 890 900
VESIVAEASD FVTEVLKIDH KYHKSIVGSG GHILREIISK AGGEEIRNKS
910 920 930 940 950
VDIPNADSEN KDITVQGPQK FVKKVVEEIN KIVKDAENSV TKTIDIPAER
960 970 980 990 1000
KGALIGPGGI VRRQLESEFN INLFVPNKDD PSGKITITGA PENVEKAEKK
1010 1020 1030 1040 1050
ILNEIIRENF DREVDVPASI YEYVSERGAF IQKLRMDLSV NVRFGNTSKK
1060 1070 1080 1090 1100
ANKLARAPIE IPLEKVCGST EGENAEKTKF TIEEVGAPTS SEEGDITMRL
1110 1120 1130 1140 1150
TYEPIDLSSI LSDGEEKEVT KDTSNDSAKK EEALDTAVKL IKERIAKAPS
1160 1170 1180 1190 1200
ATYAGYVWGA DTRRFNMIVG PGGSNIKKIR EAADVIINVP RKSDKVNDVV
1210 1220
YIRGTKAGVE KAGEMVLKSL RR
Length:1,222
Mass (Da):134,810
Last modified:November 1, 1995 - v3
Checksum:i504BBC9CAFD40758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287E → G in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti303L → S in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti308K → Q in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti330E → K in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti362D → G in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti411I → N in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti884L → F in CAA28383 (PubMed:8641269).Curated1
Sequence conflicti886E → D in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti960I → V in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti1067C → R in CAA46597 (PubMed:8533468).Curated1
Sequence conflicti1087A → E in CAA46597 (PubMed:8533468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65645 Genomic DNA Translation: CAA46597.1
Z49355 Genomic DNA Translation: CAA89373.1
Z49354 Genomic DNA Translation: CAA89371.1
X88851 Genomic DNA Translation: CAA61316.1
X83502 Genomic DNA Translation: CAA58490.1
X04679 mRNA Translation: CAA28383.1
BK006943 Genomic DNA Translation: DAA08719.1
PIRiS56030
RefSeqiNP_012455.1, NM_001181513.1

Genome annotation databases

EnsemblFungiiYJL080C; YJL080C; YJL080C
GeneIDi853365
KEGGisce:YJL080C

Similar proteinsi

Entry informationi

Entry nameiSC160_YEAST
AccessioniPrimary (citable) accession number: P06105
Secondary accession number(s): D6VWA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health