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Protein

Cytochrome c oxidase subunit 3

Gene

ctaE

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-972-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Oxidase aa(3) subunit 3
Gene namesi
Name:ctaE
Synonyms:coiII
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514CytoplasmicAdd
BLAST
Transmembranei16 – 3621HelicalAdd
BLAST
Topological domaini37 – 4812PeriplasmicAdd
BLAST
Transmembranei49 – 7729HelicalAdd
BLAST
Topological domaini78 – 792Cytoplasmic
Transmembranei80 – 11536HelicalAdd
BLAST
Topological domaini116 – 13924PeriplasmicAdd
BLAST
Transmembranei140 – 16627HelicalAdd
BLAST
Topological domaini167 – 1682Cytoplasmic
Transmembranei169 – 19729HelicalAdd
BLAST
Topological domaini198 – 2036Periplasmic
Transmembranei204 – 23734HelicalAdd
BLAST
Topological domaini238 – 2447Cytoplasmic
Transmembranei245 – 27430HelicalAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 274273Cytochrome c oxidase subunit 3PRO_0000183886Add
BLAST

Structurei

Secondary structure

1
274
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 3620Combined sources
Beta strandi42 – 443Combined sources
Turni51 – 533Combined sources
Helixi54 – 7522Combined sources
Helixi81 – 11434Combined sources
Turni119 – 1235Combined sources
Turni138 – 1403Combined sources
Helixi141 – 16525Combined sources
Helixi169 – 1757Combined sources
Helixi177 – 1804Combined sources
Helixi182 – 19312Combined sources
Helixi194 – 1963Combined sources
Beta strandi201 – 2033Combined sources
Helixi205 – 23531Combined sources
Turni236 – 2383Combined sources
Helixi246 – 26722Combined sources
Helixi268 – 2725Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLEX-ray3.00C2-274[»]
ProteinModelPortaliP06030.
SMRiP06030. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06030.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVKNHDYQ ILPPSIWPFF GAIGAFVMLT GAVAWMKGIT FFGLPVEGPW
60 70 80 90 100
MFLIGLVGVL YVMFGWWADV VNEGETGEHT PVVRIGLQYG FILFIMSEVM
110 120 130 140 150
FFVAWFWAFI KNALYPMGPD SPIKDGVWPP EGIVTFDPWH LPLINTLILL
160 170 180 190 200
LSGVAVTWAH HAFVLEGDRK TTINGLIVAV ILGVCFTGLQ AYEYSHAAFG
210 220 230 240 250
LADTVYAGAF YMATGFHGAH VIIGTIFLFV CLIRLLKGQM TQKQHVGFEA
260 270
AAWYWHFVDV VWLFLFVVIY IWGR
Length:274
Mass (Da):30,786
Last modified:January 23, 2007 - v3
Checksum:i082F95AF9AD4A27B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04406 Genomic DNA. Translation: CAA27995.1.
X05828 Genomic DNA. Translation: CAA29272.1.
PIRiS03807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04406 Genomic DNA. Translation: CAA27995.1.
X05828 Genomic DNA. Translation: CAA29272.1.
PIRiS03807.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLEX-ray3.00C2-274[»]
ProteinModelPortaliP06030.
SMRiP06030. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-972-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP06030.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
    Raitio M., Jalli T., Saraste M.
    EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S1657.
  2. "A gene in Paracoccus for subunit III of cytochrome oxidase."
    Saraste M., Raitio M., Jalli T., Peraemaa A.
    FEBS Lett. 206:154-156(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144.
    Strain: S1657.
  3. "The Paracoccus denitrificans cytochrome aa3 has a third subunit."
    Haltia T., Puustinen A., Finel M.
    Eur. J. Biochem. 172:543-546(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16.
  4. "Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
    Iwata S., Ostermeier C., Ludwig B., Michel H.
    Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiCOX3_PARDE
AccessioniPrimary (citable) accession number: P06030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.