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P06030 (COX3_PARDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Oxidase aa(3) subunit 3
Gene names
Name:ctaE
Synonyms:coiII
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 274273Cytochrome c oxidase subunit 3
PRO_0000183886

Regions

Topological domain2 – 1514Cytoplasmic
Transmembrane16 – 3621Helical
Topological domain37 – 4812Periplasmic
Transmembrane49 – 7729Helical
Topological domain78 – 792Cytoplasmic
Transmembrane80 – 11536Helical
Topological domain116 – 13924Periplasmic
Transmembrane140 – 16627Helical
Topological domain167 – 1682Cytoplasmic
Transmembrane169 – 19729Helical
Topological domain198 – 2036Periplasmic
Transmembrane204 – 23734Helical
Topological domain238 – 2447Cytoplasmic
Transmembrane245 – 27430Helical

Secondary structure

.............................. 274
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P06030 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 082F95AF9AD4A27B

FASTA27430,786
        10         20         30         40         50         60 
MAHVKNHDYQ ILPPSIWPFF GAIGAFVMLT GAVAWMKGIT FFGLPVEGPW MFLIGLVGVL 

        70         80         90        100        110        120 
YVMFGWWADV VNEGETGEHT PVVRIGLQYG FILFIMSEVM FFVAWFWAFI KNALYPMGPD 

       130        140        150        160        170        180 
SPIKDGVWPP EGIVTFDPWH LPLINTLILL LSGVAVTWAH HAFVLEGDRK TTINGLIVAV 

       190        200        210        220        230        240 
ILGVCFTGLQ AYEYSHAAFG LADTVYAGAF YMATGFHGAH VIIGTIFLFV CLIRLLKGQM 

       250        260        270 
TQKQHVGFEA AAWYWHFVDV VWLFLFVVIY IWGR 

« Hide

References

[1]"Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans."
Raitio M., Jalli T., Saraste M.
EMBO J. 6:2825-2833(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S1657.
[2]"A gene in Paracoccus for subunit III of cytochrome oxidase."
Saraste M., Raitio M., Jalli T., Peraemaa A.
FEBS Lett. 206:154-156(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144.
Strain: S1657.
[3]"The Paracoccus denitrificans cytochrome aa3 has a third subunit."
Haltia T., Puustinen A., Finel M.
Eur. J. Biochem. 172:543-546(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-16.
[4]"Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
Iwata S., Ostermeier C., Ludwig B., Michel H.
Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04406 Genomic DNA. Translation: CAA27995.1.
X05828 Genomic DNA. Translation: CAA29272.1.
PIRS03807.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLEX-ray3.00C2-273[»]
ProteinModelPortalP06030.
SMRP06030. Positions 2-274.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP06030.

Entry information

Entry nameCOX3_PARDE
AccessionPrimary (citable) accession number: P06030
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references