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P06029 (COX2_CYBSA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:OXI1
Encoded onMitochondrion
OrganismCyberlindnera saturnus (Yeast) (Williopsis saturnus)
Taxonomic identifier907340 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Cytochrome c oxidase subunit 2
PRO_0000006046

Regions

Topological domain12 – 3827Mitochondrial intermembrane Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 7819Mitochondrial matrix Potential
Transmembrane79 – 10123Helical; Potential
Topological domain102 – 247146Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P06029 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 8AFAEE9A1EA249CA

FASTA24727,927
        10         20         30         40         50         60 
MLLLINNLIL NDVPTPWGLY FQDSSTPNQE GIIELHDNIM FYLVLILCTV SWLLFSIVKD 

        70         80         90        100        110        120 
SSKNPLPHKY LVHGQTIEII WTILPAVVLL IIAFPSFILL YLCDEVISPA MTIKAIGLQW 

       130        140        150        160        170        180 
YWRYEYSDFI NDSGETIEFE SYVIPEDLLE DGQLRLLDTD TSVVCPVNTH IRFIVSAADV 

       190        200        210        220        230        240 
IHDFAIPSLG IKVVASPGRL NQVSALIQRE GVYYGMCSET CGVAHSAMPM KIEVVSTKEF 


LTWLNEQ 

« Hide

References

[1]"Nucleotide sequence of the mitochondrial cytochrome oxidase subunit II gene in the yeast Hansenula saturnus."
Lawson J.E., Deters D.W.
Curr. Genet. 9:351-360(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02439 Genomic DNA. Translation: CAA26284.1.
PIROBHQMS. S07165.

3D structure databases

ProteinModelPortalP06029.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CYBSA
AccessionPrimary (citable) accession number: P06029
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families