ID GLPB_HUMAN Reviewed; 91 AA. AC P06028; Q0VAF4; Q58HE9; Q58HF0; Q58HF1; Q9UCH7; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 2. DT 13-OCT-2009, entry version 97. DE RecName: Full=Glycophorin-B; DE AltName: Full=PAS-3; DE AltName: Full=Sialoglycoprotein delta; DE AltName: Full=SS-active sialoglycoprotein; DE AltName: CD_antigen=CD235b; DE Flags: Precursor; GN Name=GYPB; Synonyms=GPB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=88016166; PubMed=3477806; DOI=10.1073/pnas.84.19.6735; RA Siebert P.D., Fukuda M.; RT "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence RT and genomic relationship to glycophorin A."; RL Proc. Natl. Acad. Sci. U.S.A. 84:6735-6739(1987). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-84. RX MEDLINE=89061610; PubMed=3196288; RA Tate C.G., Tanner M.J.A.; RT "Isolation of cDNA clones for human erythrocyte membrane RT sialoglycoproteins alpha and delta."; RL Biochem. J. 254:743-750(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=89282822; PubMed=2734312; DOI=10.1073/pnas.86.12.4619; RA Kudo S., Fukuda M.; RT "Structural organization of glycophorin A and B genes: glycophorin B RT gene evolved by homologous recombination at Alu repeat sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 86:4619-4623(1989). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT M(V) SER-22, VARIANTS MIT MET-48 RP AND HIS-54, AND VARIANT S(D) ARG-58. RC TISSUE=Blood; RX MEDLINE=21137817; PubMed=11239234; RX DOI=10.1046/j.1537-2995.2001.41020269.x; RA Storry J.R., Reid M.E., MacLennan S., Lubenko A., Nortman P.; RT "The low-incidence MNS antigens M(v), s(D), and Mit arise from single RT amino acid substitutions on GPB."; RL Transfusion 41:269-275(2001). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-84. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-58. RC TISSUE=Blood; RX MEDLINE=91201388; PubMed=2016325; RA Huang C.-H., Blumenfeld O.O.; RT "Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. RT Use of a pseudoexon in construction of two delta-alpha-delta hybrid RT genes resulting in antigenic diversification."; RL J. Biol. Chem. 266:7248-7255(1991). RN [7] RP PROTEIN SEQUENCE OF 20-90. RX MEDLINE=87246688; PubMed=3595615; RX DOI=10.1111/j.1432-1033.1987.tb13479.x; RA Dahr W., Beyreuther K., Moulds J., Unger P.; RT "Hybrid glycophorins from human erythrocyte membranes. I. Isolation RT and complete structural analysis of the hybrid sialoglycoprotein from RT Dantu-positive red cells of the N.E. variety."; RL Eur. J. Biochem. 166:31-36(1987). RN [8] RP PROTEIN SEQUENCE OF 20-90. RX MEDLINE=87194779; PubMed=3571235; RA Blanchard D., Dahr W., Hummel M., Latron F., Beyreuther K., RA Cartron J.-P.; RT "Glycophorins B and C from human erythrocyte membranes. Purification RT and sequence analysis."; RL J. Biol. Chem. 262:5808-5811(1987). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-45. RX MEDLINE=92305340; PubMed=1611092; RA Huang C.-H., Spruell P., Moulds J.J., Blumenfeld O.O.; RT "Molecular basis for the human erythrocyte glycophorin specifying the RT Miltenberger class I (MiI) phenotype."; RL Blood 80:257-263(1992). RN [10] RP PROTEIN SEQUENCE OF 20-40, AND GLYCOSYLATION AT THR-36 AND SER-38. RX MEDLINE=93211988; PubMed=7681597; DOI=10.1073/pnas.90.6.2495; RA Nakada H., Inoue M., Numata Y., Tanaka N., Funakoshi I., Fukui S., RA Mellors A., Yamashina I.; RT "Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS RT 128)."; RL Proc. Natl. Acad. Sci. U.S.A. 90:2495-2499(1993). CC -!- FUNCTION: This protein is a minor sialoglycoprotein in erythrocyte CC membranes. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. CC -!- PTM: The N-terminal extracellular domain is heavily glycosylated CC on serine and threonine residues. CC -!- POLYMORPHISM: Along with GYPA, GYPB is responsible for the MNS CC blood group system. The molecular basis of the S/s blood group CC antigen is a single variation in position 48; Thr-48 corresponds CC to s=MSN4 and Met-48 to S=MNS3. CC -!- SIMILARITY: Belongs to the glycophorin-A family. CC -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene CC mutation database; CC URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=mns"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; J02982; AAA52573.1; -; mRNA. DR EMBL; X08055; CAB42645.1; -; mRNA. DR EMBL; M24137; AAA58626.1; -; Genomic_DNA. DR EMBL; M24130; AAA58626.1; JOINED; Genomic_DNA. DR EMBL; M24131; AAA58626.1; JOINED; Genomic_DNA. DR EMBL; M24135; AAA58626.1; JOINED; Genomic_DNA. DR EMBL; AY950609; AAX53130.1; -; mRNA. DR EMBL; AY950610; AAX53131.1; -; mRNA. DR EMBL; AY950611; AAX53132.1; -; mRNA. DR EMBL; BC069310; AAH69310.1; -; mRNA. DR EMBL; BC121077; AAI21078.1; -; mRNA. DR EMBL; BC121078; AAI21079.1; -; mRNA. DR EMBL; M60708; AAC63048.1; -; Genomic_DNA. DR IPI; IPI00024995; -. DR PIR; B33931; B33931. DR RefSeq; NP_002091.2; -. DR UniGene; Hs.654368; -. DR HSSP; P02724; 1AFO. DR STRING; P06028; -. DR GlycoSuiteDB; P06028; -. DR PRIDE; P06028; -. DR Ensembl; ENST00000283126; ENSP00000283126; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000283128; ENSP00000283128; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000306959; ENSP00000306419; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000324022; ENSP00000324483; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000360771; ENSP00000354003; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000394119; ENSP00000377677; ENSG00000170180; Homo sapiens. DR Ensembl; ENST00000429670; ENSP00000394200; ENSG00000170180; Homo sapiens. DR GeneID; 2994; -. DR KEGG; hsa:2994; -. DR CTD; 2994; -. DR GeneCards; GC04M145136; -. DR HGNC; HGNC:4703; GYPB. DR MIM; 111740; gene+phenotype. DR PharmGKB; PA29081; -. DR HOVERGEN; P06028; -. DR NextBio; 11866; -. DR Bgee; P06028; -. DR CleanEx; HS_GYPB; -. DR Genevestigator; P06028; -. DR GermOnline; ENSG00000153143; Homo sapiens. DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc. DR InterPro; IPR001195; Glycophorin. DR InterPro; IPR018938; Glycophorin_CS. DR PANTHER; PTHR13813; Glycophorin_A_B; 1. DR Pfam; PF01102; Glycophorin_A; 1. DR PROSITE; PS00312; GLYCOPHORIN_A; 1. PE 1: Evidence at protein level; KW Blood group antigen; Cell membrane; Complete proteome; KW Direct protein sequencing; Glycoprotein; Membrane; Polymorphism; KW Sialic acid; Signal; Transmembrane. FT SIGNAL 1 19 FT CHAIN 20 91 Glycophorin-B. FT /FTId=PRO_0000012136. FT TOPO_DOM 20 59 Extracellular (Potential). FT TRANSMEM 60 81 Potential. FT TOPO_DOM 82 91 Cytoplasmic (Potential). FT SITE 33 33 Not glycosylated. FT SITE 34 34 Not glycosylated. FT CARBOHYD 36 36 O-linked (GlcNAc...). FT CARBOHYD 38 38 O-linked (GlcNAc...). FT VARIANT 22 22 T -> S (in M(v) antigen). FT /FTId=VAR_047948. FT VARIANT 48 48 T -> M (in S antigen and Mit antigen; FT dbSNP:rs7683365). FT /FTId=VAR_003192. FT VARIANT 54 54 R -> H (in Mit antigen). FT /FTId=VAR_047949. FT VARIANT 58 58 P -> R (in s(D) antigen). FT /FTId=VAR_047950. FT VARIANT 84 84 T -> S (in dbSNP:rs1132783). FT /FTId=VAR_030785. FT CONFLICT 69 69 C -> S (in Ref. 7; AA sequence and 8; AA FT sequence). SQ SEQUENCE 91 AA; 9796 MW; F415A64BAA929B7F CRC64; MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ LVHRFTVPAP VVIILIILCV MAGIIGTILL ISYTIRRLIK A //