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P06028

- GLPB_HUMAN

UniProt

P06028 - GLPB_HUMAN

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Protein

Glycophorin-B

Gene
GYPB, GPB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is a minor sialoglycoprotein in erythrocyte membranes.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei33 – 331Not glycosylated
Sitei34 – 341Not glycosylated

Keywords - Molecular functioni

Blood group antigen

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-B
Alternative name(s):
PAS-3
SS-active sialoglycoprotein
Sialoglycoprotein delta
CD_antigen: CD235b
Gene namesi
Name:GYPB
Synonyms:GPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4703. GYPB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 5940Extracellular Reviewed predictionAdd
BLAST
Transmembranei60 – 8122Helical; Reviewed predictionAdd
BLAST
Topological domaini82 – 9110Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi111740. gene+phenotype.
PharmGKBiPA29081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19193 PublicationsAdd
BLAST
Chaini20 – 9172Glycophorin-BPRO_0000012136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361O-linked (GalNAc...)1 Publication
Glycosylationi38 – 381O-linked (GalNAc...)1 Publication

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.1 Publication

Keywords - PTMi

Glycoprotein

PTM databases

UniCarbKBiP06028.

Expressioni

Gene expression databases

ArrayExpressiP06028.
BgeeiP06028.
CleanExiHS_GYPB.
GenevestigatoriP06028.

Structurei

3D structure databases

ProteinModelPortaliP06028.
SMRiP06028. Positions 49-91.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000089933.
HOVERGENiHBG005850.
KOiK06575.
OMAiADSKERY.
PhylomeDBiP06028.
TreeFamiTF338555.

Family and domain databases

InterProiIPR001195. Glycophorin.
IPR018938. Glycophorin_CS.
[Graphical view]
PANTHERiPTHR13813. PTHR13813. 1 hit.
PROSITEiPS00312. GLYCOPHORIN_A. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P06028-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ   50
LVHRFTVPAP VVIILIILCV MAGIIGTILL ISYSIRRLIK A 91
Length:91
Mass (Da):9,782
Last modified:March 21, 2012 - v3
Checksum:iEF15A64BAA929B7B
GO
Isoform 2 (identifier: P06028-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-45: Missing.

Show »
Length:58
Mass (Da):6,352
Checksum:i1DE98AE83FBB43A2
GO

Polymorphismi

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221T → S in M(v) antigen. 1 Publication
VAR_047948
Natural varianti48 – 481T → M in S antigen and Mit antigen. 1 Publication
Corresponds to variant rs7683365 [ dbSNP | Ensembl ].
VAR_003192
Natural varianti54 – 541R → H in Mit antigen. 1 Publication
VAR_047949
Natural varianti58 – 581P → R in s(D) antigen. 1 Publication
VAR_047950
Natural varianti84 – 841S → T.3 Publications
Corresponds to variant rs1132783 [ dbSNP | Ensembl ].
VAR_030785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei13 – 4533Missing in isoform 2. VSP_047824Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691C → S AA sequence 1 Publication
Sequence conflicti69 – 691C → S AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02982 mRNA. Translation: AAA52573.1.
X08055 mRNA. Translation: CAB42645.1.
M24137
, M24130, M24131, M24135 Genomic DNA. Translation: AAA58626.1.
AY950609 mRNA. Translation: AAX53130.1.
AY950610 mRNA. Translation: AAX53131.1.
AY950611 mRNA. Translation: AAX53132.1.
EU338223 mRNA. Translation: ACA96781.1.
EU338235 mRNA. Translation: ACA96793.1.
AC093890 Genomic DNA. No translation available.
AC107223 Genomic DNA. No translation available.
AC110762 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05058.1.
BC069310 mRNA. Translation: AAH69310.1.
BC121077 mRNA. Translation: AAI21078.1.
BC121078 mRNA. Translation: AAI21079.1.
M60708 Genomic DNA. Translation: AAC63048.1.
CCDSiCCDS54809.1. [P06028-1]
PIRiB33931.
RefSeqiNP_002091.3. NM_002100.4.
UniGeneiHs.654368.

Genome annotation databases

EnsembliENST00000283126; ENSP00000283126; ENSG00000250361. [P06028-1]
ENST00000502664; ENSP00000427690; ENSG00000250361. [P06028-1]
ENST00000513128; ENSP00000425244; ENSG00000250361. [P06028-2]
GeneIDi2994.
KEGGihsa:2994.

Polymorphism databases

DMDMi380865467.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02982 mRNA. Translation: AAA52573.1 .
X08055 mRNA. Translation: CAB42645.1 .
M24137
, M24130 , M24131 , M24135 Genomic DNA. Translation: AAA58626.1 .
AY950609 mRNA. Translation: AAX53130.1 .
AY950610 mRNA. Translation: AAX53131.1 .
AY950611 mRNA. Translation: AAX53132.1 .
EU338223 mRNA. Translation: ACA96781.1 .
EU338235 mRNA. Translation: ACA96793.1 .
AC093890 Genomic DNA. No translation available.
AC107223 Genomic DNA. No translation available.
AC110762 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05058.1 .
BC069310 mRNA. Translation: AAH69310.1 .
BC121077 mRNA. Translation: AAI21078.1 .
BC121078 mRNA. Translation: AAI21079.1 .
M60708 Genomic DNA. Translation: AAC63048.1 .
CCDSi CCDS54809.1. [P06028-1 ]
PIRi B33931.
RefSeqi NP_002091.3. NM_002100.4.
UniGenei Hs.654368.

3D structure databases

ProteinModelPortali P06028.
SMRi P06028. Positions 49-91.
ModBasei Search...
MobiDBi Search...

PTM databases

UniCarbKBi P06028.

Polymorphism databases

DMDMi 380865467.

Protocols and materials databases

DNASUi 2994.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283126 ; ENSP00000283126 ; ENSG00000250361 . [P06028-1 ]
ENST00000502664 ; ENSP00000427690 ; ENSG00000250361 . [P06028-1 ]
ENST00000513128 ; ENSP00000425244 ; ENSG00000250361 . [P06028-2 ]
GeneIDi 2994.
KEGGi hsa:2994.

Organism-specific databases

CTDi 2994.
GeneCardsi GC04M144918.
HGNCi HGNC:4703. GYPB.
MIMi 111740. gene+phenotype.
neXtProti NX_P06028.
PharmGKBi PA29081.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000089933.
HOVERGENi HBG005850.
KOi K06575.
OMAi ADSKERY.
PhylomeDBi P06028.
TreeFami TF338555.

Miscellaneous databases

GeneWikii GYPB.
GenomeRNAii 2994.
NextBioi 11866.
PROi P06028.
SOURCEi Search...

Gene expression databases

ArrayExpressi P06028.
Bgeei P06028.
CleanExi HS_GYPB.
Genevestigatori P06028.

Family and domain databases

InterProi IPR001195. Glycophorin.
IPR018938. Glycophorin_CS.
[Graphical view ]
PANTHERi PTHR13813. PTHR13813. 1 hit.
PROSITEi PS00312. GLYCOPHORIN_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A."
    Siebert P.D., Fukuda M.
    Proc. Natl. Acad. Sci. U.S.A. 84:6735-6739(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-84.
  2. "Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta."
    Tate C.G., Tanner M.J.A.
    Biochem. J. 254:743-750(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences."
    Kudo S., Fukuda M.
    Proc. Natl. Acad. Sci. U.S.A. 86:4619-4623(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-84.
  4. "Extensive alternative splicing of glycophorins in Southeast Asian populations."
    Hsu K., Chi N., Lin M.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Blood.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB."
    Storry J.R., Reid M.E., MacLennan S., Lubenko A., Nortman P.
    Transfusion 41:269-275(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT M(V) SER-22, VARIANTS MIT MET-48 AND HIS-54, VARIANT S(D) ARG-58, VARIANT THR-84.
    Tissue: Blood.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification."
    Huang C.-H., Blumenfeld O.O.
    J. Biol. Chem. 266:7248-7255(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-58.
    Tissue: Blood.
  10. "Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety."
    Dahr W., Beyreuther K., Moulds J., Unger P.
    Eur. J. Biochem. 166:31-36(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-90.
  11. "Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."
    Blanchard D., Dahr W., Hummel M., Latron F., Beyreuther K., Cartron J.-P.
    J. Biol. Chem. 262:5808-5811(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-90.
  12. "Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype."
    Huang C.-H., Spruell P., Moulds J.J., Blumenfeld O.O.
    Blood 80:257-263(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-45.
  13. Cited for: PROTEIN SEQUENCE OF 20-40, GLYCOSYLATION AT THR-36 AND SER-38.

Entry informationi

Entry nameiGLPB_HUMAN
AccessioniPrimary (citable) accession number: P06028
Secondary accession number(s): B8Q174
, E2QBW7, Q0VAF4, Q58HE9, Q58HF0, Q58HF1, Q9UCH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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