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Reviewed, UniProtKB/Swiss-Prot P06028 (GLPB_HUMAN)

Last modified July 22, 2008. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glycophorin-B
Alternative name(s):
    PAS-3
    Sialoglycoprotein delta
    SS-active sialoglycoprotein
    CD_antigen=CD235b
Gene names
Name: GYPB
Synonyms: GPB
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This protein is a minor sialoglycoprotein in erythrocyte membranes.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues By similarity.

Polymorphism

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

Sequence similarities

Belongs to the glycophorin A family.

Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
   LigandSialic acid
   Molecular functionBlood group antigen
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1919
Chain20 – 9172Glycophorin-B

Regions

Topological domain20 – 5940Extracellular Potential
Transmembrane60 – 8122 Potential
Topological domain82 – 9110Cytoplasmic Potential

Natural variations

Natural variant481T → M in S antigen. dbSNP rs7683365.
Natural variant841T → S: dbSNP rs1132783.

Experimental info

Sequence conflict691C → S Ref.6 Ref.7

Sequences

Sequence LengthMass (Da)Tools
P06028-1 [UniParc].

Last modified January 1, 1990. Version 2.
Checksum: F415A64BAA929B7F

FASTA919,796
        10         20         30         40         50         60 
MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ LVHRFTVPAP 

        70         80         90 
VVIILIILCV MAGIIGTILL ISYTIRRLIK A 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A."
Siebert P.D., Fukuda M.
Proc. Natl. Acad. Sci. U.S.A. 84:6735-6739(1987) [PubMed: 3477806] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta."
Tate C.G., Tanner M.J.A.
Biochem. J. 254:743-750(1988) [PubMed: 3196288] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-84.
[3]"Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences."
Kudo S., Fukuda M.
Proc. Natl. Acad. Sci. U.S.A. 86:4619-4623(1989) [PubMed: 2734312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-84.
[5]"Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification."
Huang C.-H., Blumenfeld O.O.
J. Biol. Chem. 266:7248-7255(1991) [PubMed: 2016325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-58.
Tissue: Blood.
[6]"Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."
Blanchard D., Dahr W., Hummel M., Latron F., Beyreuther K., Cartron J.-P.
J. Biol. Chem. 262:5808-5811(1987) [PubMed: 3571235] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-90.
[7]"Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety."
Dahr W., Beyreuther K., Moulds J., Unger P.
Eur. J. Biochem. 166:31-36(1987) [PubMed: 3595615] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-90.
[8]"Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype."
Huang C.-H., Spruell P., Moulds J.J., Blumenfeld O.O.
Blood 80:257-263(1992) [PubMed: 1611092] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 20-45.

Web resources

BGMUT

Blood group antigen gene mutation database"

Cross-references

Sequence databases

J02982 mRNA. Translation: AAA52573.1.
X08055 mRNA. Translation: CAB42645.1.
M24137 expand/collapse EMBL AC list , M24130, M24131, M24135 Genomic DNA. Translation: AAA58626.1.
BC069310 mRNA. Translation: AAH69310.1.
BC121077 mRNA. Translation: AAI21078.1.
BC121078 mRNA. Translation: AAI21079.1.
M60708 Genomic DNA. Translation: AAC63048.1.
PIRB33931.
RefSeqNP_002091.2.
UniGeneHs.654368

3D structure databases

HSSPHSSP built from PDB template 1AFO based on UniProtKB P02724.
ModBaseSearch...

PTM databases

GlycoSuiteDBP06028.

Genome annotation databases

EnsemblENSG00000153143. Homo sapiens. [Contig view]
GeneID2994.
KEGGhsa:2994.

Organism-specific databases

HGNCHGNC:4703. GYPB.
MIM111740. gene+phenotype.
PharmGKBPA29081.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOVERGENP06028.

Gene expression databases

CleanExHS_GYPB.
GermOnlineENSG00000153143. Homo sapiens.

Family and domain databases

InterProIPR001195. Glycophorin_A_B.
[Graphical view]
PANTHERPTHR13813. Glycophorin_A_B. 1 hit.
PfamPF01102. Glycophorin_A. 1 hit.
[Graphical view]
PROSITEPS00312. GLYCOPHORIN_A. 1 hit.
[Graphical view]
ProDomP06028.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameGLPB_HUMAN
AccessionPrimary (citable) accession number: P06028
Secondary accession number(s): Q0VAF4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 1, 1990
Last modified: July 22, 2008
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents