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Protein

Opsin Rh1

Gene

ninaE

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Miscellaneous

Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells.

Absorptioni

Abs(max)=480 nm

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: FlyBase

GO - Biological processi

  • adult locomotory behavior Source: FlyBase
  • cellular response to light stimulus Source: FlyBase
  • detection of UV Source: FlyBase
  • detection of visible light Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • negative regulation of compound eye retinal cell programmed cell death Source: FlyBase
  • optomotor response Source: FlyBase
  • phospholipase C-activating rhodopsin mediated signaling pathway Source: FlyBase
  • photoreceptor cell morphogenesis Source: FlyBase
  • phototaxis Source: FlyBase
  • phototransduction Source: FlyBase
  • protein-chromophore linkage Source: UniProtKB-KW
  • response to light intensity Source: FlyBase
  • rhabdomere development Source: FlyBase
  • thermotaxis Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-DME-2187335 The retinoid cycle in cones (daylight vision)
R-DME-2453902 The canonical retinoid cycle in rods (twilight vision)
R-DME-2485179 Activation of the phototransduction cascade
R-DME-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-DME-419771 Opsins
R-DME-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin Rh1
Alternative name(s):
Neither inactivation nor afterpotential E protein
Outer R1-R6 photoreceptor cells opsin
Gene namesi
Name:ninaE
Synonyms:Rh1
ORF Names:CG4550
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002940 ninaE

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularAdd BLAST49
Transmembranei50 – 74Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini75 – 86CytoplasmicAdd BLAST12
Transmembranei87 – 112Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini113 – 126ExtracellularAdd BLAST14
Transmembranei127 – 146Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini147 – 165CytoplasmicAdd BLAST19
Transmembranei166 – 189Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini190 – 213ExtracellularAdd BLAST24
Transmembranei214 – 241Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini242 – 276CytoplasmicAdd BLAST35
Transmembranei277 – 300Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini301 – 307Extracellular7
Transmembranei308 – 332Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini333 – 373CytoplasmicAdd BLAST41

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001976221 – 373Opsin Rh1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi123 ↔ 200PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei319N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06002
PRIDEiP06002

PTM databases

iPTMnetiP06002

Expressioni

Gene expression databases

BgeeiFBgn0002940
GenevisibleiP06002 DM

Interactioni

Protein-protein interaction databases

BioGridi67356, 70 interactors
DIPiDIP-17500N
IntActiP06002, 5 interactors
MINTiP06002
STRINGi7227.FBpp0083266

Structurei

3D structure databases

ProteinModelPortaliP06002
SMRiP06002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
InParanoidiP06002
KOiK13802
OMAiWTIAPMF
OrthoDBiEOG091G0ALC
PhylomeDBiP06002

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR001735 Opsin_RH1/RH2
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00576 OPSINRH1RH2
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

P06002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFAVAAAQ LGPHFAPLSN GSVVDKVTPD MAHLISPYWN QFPAMDPIWA
60 70 80 90 100
KILTAYMIMI GMISWCGNGV VIYIFATTKS LRTPANLLVI NLAISDFGIM
110 120 130 140 150
ITNTPMMGIN LYFETWVLGP MMCDIYAGLG SAFGCSSIWS MCMISLDRYQ
160 170 180 190 200
VIVKGMAGRP MTIPLALGKI AYIWFMSSIW CLAPAFGWSR YVPEGNLTSC
210 220 230 240 250
GIDYLERDWN PRSYLIFYSI FVYYIPLFLI CYSYWFIIAA VSAHEKAMRE
260 270 280 290 300
QAKKMNVKSL RSSEDAEKSA EGKLAKVALV TITLWFMAWT PYLVINCMGL
310 320 330 340 350
FKFEGLTPLN TIWGACFAKS AACYNPIVYG ISHPKYRLAL KEKCPCCVFG
360 370
KVDDGKSSDA QSQATASEAE SKA
Length:373
Mass (Da):41,495
Last modified:August 13, 1987 - v1
Checksum:iFFF36C90DDD68294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02315 Genomic DNA Translation: AAA28733.1
K02320
, K02316, K02317, K02318, K02319 Genomic DNA Translation: AAA28735.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF55712.1
BT010221 mRNA Translation: AAQ23539.1
BT023714 mRNA Translation: AAY85114.1
BT029277 mRNA Translation: ABK30914.1
PIRiA90864 OOFF
RefSeqiNP_524407.1, NM_079683.3
UniGeneiDm.6744

Genome annotation databases

EnsemblMetazoaiFBtr0083857; FBpp0083266; FBgn0002940
GeneIDi42367
KEGGidme:Dmel_CG4550

Similar proteinsi

Entry informationi

Entry nameiOPS1_DROME
AccessioniPrimary (citable) accession number: P06002
Secondary accession number(s): A0AVV9
, Q4QPQ2, Q9TX56, Q9VDS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health