Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05964

- S10A6_RAT

UniProt

P05964 - S10A6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein S100-A6

Gene

S100a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi61 – 72122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. ion transmembrane transporter activity Source: RGD
  3. zinc ion binding Source: Ensembl

GO - Biological processi

  1. ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
Calcyclin
Prolactin receptor-associated protein
S100 calcium-binding protein A6
Gene namesi
Name:S100a6
Synonyms:Cacy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620264. S100a6.

Subcellular locationi

Nucleus envelope By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  4. nucleus Source: UniProtKB-KW
  5. perinuclear region of cytoplasm Source: Ensembl
  6. ruffle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Protein S100-A6PRO_0000143987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-acetyllysineBy similarity
Modified residuei47 – 471N6-acetyllysine; alternateBy similarity
Modified residuei47 – 471N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05964.
PRIDEiP05964.

Expressioni

Gene expression databases

ExpressionAtlasiP05964. baseline and differential.
GenevestigatoriP05964.

Interactioni

Subunit structurei

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.By similarity

Protein-protein interaction databases

IntActiP05964. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP05964.
SMRiP05964. Positions 2-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini48 – 8336EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40006.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05964.
OMAiCFATIND.
OrthoDBiEOG78WKVD.
PhylomeDBiP05964.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05964-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGAKLQD
60 70 80
AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK
Length:89
Mass (Da):10,035
Last modified:April 13, 2004 - v3
Checksum:i2AA1A4163D57DC87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891K → KG no nucleotide entry (PubMed:2448309)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132717 mRNA. Translation: CAB42002.1.
AF140232 mRNA. Translation: AAK28306.1.
PIRiB28363.
RefSeqiNP_445937.1. NM_053485.2.
XP_006232841.1. XM_006232779.2.
UniGeneiRn.3233.

Genome annotation databases

EnsembliENSRNOT00000015612; ENSRNOP00000015612; ENSRNOG00000011647.
GeneIDi85247.
KEGGirno:85247.
UCSCiRGD:620264. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132717 mRNA. Translation: CAB42002.1 .
AF140232 mRNA. Translation: AAK28306.1 .
PIRi B28363.
RefSeqi NP_445937.1. NM_053485.2.
XP_006232841.1. XM_006232779.2.
UniGenei Rn.3233.

3D structure databases

ProteinModelPortali P05964.
SMRi P05964. Positions 2-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P05964. 2 interactions.

Proteomic databases

PaxDbi P05964.
PRIDEi P05964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015612 ; ENSRNOP00000015612 ; ENSRNOG00000011647 .
GeneIDi 85247.
KEGGi rno:85247.
UCSCi RGD:620264. rat.

Organism-specific databases

CTDi 6277.
RGDi 620264. S100a6.

Phylogenomic databases

eggNOGi NOG40006.
GeneTreei ENSGT00760000119034.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P05964.
OMAi CFATIND.
OrthoDBi EOG78WKVD.
PhylomeDBi P05964.
TreeFami TF332727.

Miscellaneous databases

NextBioi 617322.
PROi P05964.

Gene expression databases

ExpressionAtlasi P05964. baseline and differential.
Genevestigatori P05964.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view ]
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum."
    Murphy L.C., Murphy L.J., Tsuyuki D., Duckworth M.L., Shiu R.P.C.
    J. Biol. Chem. 263:2397-2401(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Calcyclin is differentially expressed in rat testicular cells."
    Konrad L., Aumueller G.
    Biochim. Biophys. Acta 1489:440-444(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  3. Kizawa K.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 48-55, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS10A6_RAT
AccessioniPrimary (citable) accession number: P05964
Secondary accession number(s): Q9R2B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein co-purified with the prolactin receptor.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3