Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P05964 (S10A6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A6
Alternative name(s):
Calcyclin
Prolactin receptor-associated protein
S100 calcium-binding protein A6
Gene names
Name:S100a6
Synonyms:Cacy
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative By similarity.

Subunit structure

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.

Subcellular location

Nucleus envelope By similarity. Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Miscellaneous

This protein co-purified with the prolactin receptor.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8989Protein S100-A6
PRO_0000143987

Regions

Domain12 – 4736EF-hand 1
Domain48 – 8336EF-hand 2
Calcium binding20 – 33141 By similarity
Calcium binding61 – 72122 By similarity

Amino acid modifications

Modified residue401N6-acetyllysine By similarity
Modified residue471N6-acetyllysine; alternate By similarity
Modified residue471N6-succinyllysine; alternate By similarity

Experimental info

Sequence conflict891K → KG no nucleotide entry Ref.1

Sequences

Sequence LengthMass (Da)Tools
P05964 [UniParc].

Last modified April 13, 2004. Version 3.
Checksum: 2AA1A4163D57DC87

FASTA8910,035
        10         20         30         40         50         60 
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGAKLQD AEIARLMDDL 

        70         80 
DRNKDQEVNF QEYVAFLGAL ALIYNEALK 

« Hide

References

[1]"Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum."
Murphy L.C., Murphy L.J., Tsuyuki D., Duckworth M.L., Shiu R.P.C.
J. Biol. Chem. 263:2397-2401(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Calcyclin is differentially expressed in rat testicular cells."
Konrad L., Aumueller G.
Biochim. Biophys. Acta 1489:440-444(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
[3]Kizawa K.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
[4]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 48-55, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ132717 mRNA. Translation: CAB42002.1.
AF140232 mRNA. Translation: AAK28306.1.
PIRB28363.
RefSeqNP_445937.1. NM_053485.2.
XP_006232841.1. XM_006232779.1.
UniGeneRn.3233.

3D structure databases

ProteinModelPortalP05964.
SMRP05964. Positions 2-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP05964. 2 interactions.

Proteomic databases

PaxDbP05964.
PRIDEP05964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015612; ENSRNOP00000015612; ENSRNOG00000011647.
GeneID85247.
KEGGrno:85247.
UCSCRGD:620264. rat.

Organism-specific databases

CTD6277.
RGD620264. S100a6.

Phylogenomic databases

eggNOGNOG40006.
GeneTreeENSGT00740000114986.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP05964.
OMAVVNFQEY.
OrthoDBEOG78WKVD.
PhylomeDBP05964.
TreeFamTF332727.

Gene expression databases

GenevestigatorP05964.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5/S100-A6.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF14. PTHR11639:SF14. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617322.
PROP05964.

Entry information

Entry nameS10A6_RAT
AccessionPrimary (citable) accession number: P05964
Secondary accession number(s): Q9R2B7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families