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P05964

- S10A6_RAT

UniProt

P05964 - S10A6_RAT

Protein

Protein S100-A6

Gene

S100a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi61 – 72122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. ion transmembrane transporter activity Source: RGD
    3. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. ion transmembrane transport Source: GOC

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A6
    Alternative name(s):
    Calcyclin
    Prolactin receptor-associated protein
    S100 calcium-binding protein A6
    Gene namesi
    Name:S100a6
    Synonyms:Cacy
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi620264. S100a6.

    Subcellular locationi

    Nucleus envelope By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
    3. nuclear envelope Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: Ensembl
    5. ruffle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8989Protein S100-A6PRO_0000143987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-acetyllysineBy similarity
    Modified residuei47 – 471N6-acetyllysine; alternateBy similarity
    Modified residuei47 – 471N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP05964.
    PRIDEiP05964.

    Expressioni

    Gene expression databases

    GenevestigatoriP05964.

    Interactioni

    Subunit structurei

    Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.By similarity

    Protein-protein interaction databases

    IntActiP05964. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP05964.
    SMRiP05964. Positions 2-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini48 – 8336EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG40006.
    GeneTreeiENSGT00740000114986.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP05964.
    OMAiCFATIND.
    OrthoDBiEOG78WKVD.
    PhylomeDBiP05964.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05964-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGAKLQD   50
    AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK 89
    Length:89
    Mass (Da):10,035
    Last modified:April 13, 2004 - v3
    Checksum:i2AA1A4163D57DC87
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891K → KG no nucleotide entry (PubMed:2448309)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132717 mRNA. Translation: CAB42002.1.
    AF140232 mRNA. Translation: AAK28306.1.
    PIRiB28363.
    RefSeqiNP_445937.1. NM_053485.2.
    XP_006232841.1. XM_006232779.1.
    UniGeneiRn.3233.

    Genome annotation databases

    EnsembliENSRNOT00000015612; ENSRNOP00000015612; ENSRNOG00000011647.
    GeneIDi85247.
    KEGGirno:85247.
    UCSCiRGD:620264. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132717 mRNA. Translation: CAB42002.1 .
    AF140232 mRNA. Translation: AAK28306.1 .
    PIRi B28363.
    RefSeqi NP_445937.1. NM_053485.2.
    XP_006232841.1. XM_006232779.1.
    UniGenei Rn.3233.

    3D structure databases

    ProteinModelPortali P05964.
    SMRi P05964. Positions 2-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P05964. 2 interactions.

    Proteomic databases

    PaxDbi P05964.
    PRIDEi P05964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015612 ; ENSRNOP00000015612 ; ENSRNOG00000011647 .
    GeneIDi 85247.
    KEGGi rno:85247.
    UCSCi RGD:620264. rat.

    Organism-specific databases

    CTDi 6277.
    RGDi 620264. S100a6.

    Phylogenomic databases

    eggNOGi NOG40006.
    GeneTreei ENSGT00740000114986.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P05964.
    OMAi CFATIND.
    OrthoDBi EOG78WKVD.
    PhylomeDBi P05964.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 617322.
    PROi P05964.

    Gene expression databases

    Genevestigatori P05964.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum."
      Murphy L.C., Murphy L.J., Tsuyuki D., Duckworth M.L., Shiu R.P.C.
      J. Biol. Chem. 263:2397-2401(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Calcyclin is differentially expressed in rat testicular cells."
      Konrad L., Aumueller G.
      Biochim. Biophys. Acta 1489:440-444(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    3. Kizawa K.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    4. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 48-55, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiS10A6_RAT
    AccessioniPrimary (citable) accession number: P05964
    Secondary accession number(s): Q9R2B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein co-purified with the prolactin receptor.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3