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Protein

Sarcoplasmic calcium-binding protein 1

Gene
N/A
Organism
Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi17 – 281Add BLAST12
Calcium bindingi69 – 802Add BLAST12
Calcium bindingi113 – 1243Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoplasmic calcium-binding protein 1
Alternative name(s):
Sarcoplasmic calcium-binding protein I
Short name:
SCP I
OrganismiAstacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)
Taxonomic identifieri6717 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaeAstacus

Pathology & Biotechi

Protein family/group databases

Allergomei6095. Pon l 4.
6096. Pon l 4.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000736311 – 192Sarcoplasmic calcium-binding protein 1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

SCPs from crayfish, lobster, and shrimp are polymorphic dimers.

Structurei

3D structure databases

ProteinModelPortaliP05946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 39EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini56 – 91EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini136 – 171EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AYSWDNRVKY VVRYMYDIDN NGFLDKNDFE CLALRNTLIE GRGEFNEAAY
60 70 80 90 100
ANNQKIMSNL WNEIAELADF NKDGEVTIDE FKKAVQNVCV GKAFATFPAA
110 120 130 140 150
FKVFIANQFK TVDVNGDGLV GVDEYRLDCI SRSAFANIKE IDDAYNKLAT
160 170 180 190
DADKKAGGIS LARYQELYAQ FISNPDESAN AVYLFGPLKE VQ
Length:192
Mass (Da):21,625
Last modified:November 1, 1988 - v1
Checksum:iE00A2092C799EB05
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti78I → V in 1/3 of the chains. 1
Natural varianti112V → I in 1/3 of the chains. 1

Sequence databases

PIRiS02179.

Cross-referencesi

Sequence databases

PIRiS02179.

3D structure databases

ProteinModelPortaliP05946.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei6095. Pon l 4.
6096. Pon l 4.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCP1_ASTLP
AccessioniPrimary (citable) accession number: P05946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 16, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
This protein has three functional calcium-binding sites; potential site 4 has lost affinity for calcium.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.