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Protein

Myosin catalytic light chain LC-1, mantle muscle

Gene
N/A
Organism
Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca2+ dependent binding and Ca2+ dependent Mg-ATPase activity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin catalytic light chain LC-1, mantle muscle
OrganismiTodarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Taxonomic identifieri6637 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaOegopsinaOmmastrephidaeTodarodes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Myosin catalytic light chain LC-1, mantle musclePRO_0000198724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Xaa)

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2217Combined sources
Beta strandi25 – 273Combined sources
Helixi31 – 333Combined sources
Helixi34 – 407Combined sources
Helixi47 – 515Combined sources
Turni52 – 543Combined sources
Beta strandi57 – 615Combined sources
Helixi66 – 7611Combined sources
Helixi85 – 9511Combined sources
Beta strandi99 – 1035Combined sources
Helixi105 – 11410Combined sources
Beta strandi115 – 1173Combined sources
Helixi121 – 13010Combined sources
Beta strandi139 – 1424Combined sources
Helixi143 – 15210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10C2-160[»]
3I5GX-ray2.60C2-160[»]
3I5HX-ray3.40C2-160[»]
3I5IX-ray3.30C2-160[»]
ProteinModelPortaliP05945.
SMRiP05945. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 4438EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 11836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 15335EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XSQLTKDEIE EVREVFDLFD FWDGRDGDVD AAKVGDLLRC LGMNPTEAQV
60 70 80 90 100
HQHGGTKKMG EKAYKLEEIL PIYEEMSSKD TGTAADEFME AFKTFDREGQ
110 120 130 140 150
GLISSAEIRN VLKMLGERIT EDQCNDIFTF CDIREDIDGN IKYEDLMKKV
160
MAGPFPDKSD
Length:160
Mass (Da):18,171
Last modified:July 5, 2004 - v2
Checksum:i37F32498B4EA3BE2
GO

Sequence databases

PIRiA25571.

Cross-referencesi

Sequence databases

PIRiA25571.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10C2-160[»]
3I5GX-ray2.60C2-160[»]
3I5HX-ray3.40C2-160[»]
3I5IX-ray3.30C2-160[»]
ProteinModelPortaliP05945.
SMRiP05945. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP05945.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amino-acid sequence of LC-1 light chain of squid mantle muscle myosin."
    Watanabe B., Maita T., Konno K., Matsuda G.
    Biol. Chem. Hoppe-Seyler 367:1025-1032(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiMLE_TODPA
AccessioniPrimary (citable) accession number: P05945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.