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Protein

Myosin catalytic light chain LC-1, mantle muscle

Gene
N/A
Organism
Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca2+ dependent binding and Ca2+ dependent Mg-ATPase activity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin catalytic light chain LC-1, mantle muscle
OrganismiTodarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Taxonomic identifieri6637 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaOegopsinaOmmastrephidaeTodarodes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987241 – 160Myosin catalytic light chain LC-1, mantle muscleAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Blocked amino end (Xaa)1

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 22Combined sources17
Beta strandi25 – 27Combined sources3
Helixi31 – 33Combined sources3
Helixi34 – 40Combined sources7
Helixi47 – 51Combined sources5
Turni52 – 54Combined sources3
Beta strandi57 – 61Combined sources5
Helixi66 – 76Combined sources11
Helixi85 – 95Combined sources11
Beta strandi99 – 103Combined sources5
Helixi105 – 114Combined sources10
Beta strandi115 – 117Combined sources3
Helixi121 – 130Combined sources10
Beta strandi139 – 142Combined sources4
Helixi143 – 152Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10C2-160[»]
3I5GX-ray2.60C2-160[»]
3I5HX-ray3.40C2-160[»]
3I5IX-ray3.30C2-160[»]
ProteinModelPortaliP05945.
SMRiP05945.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini83 – 118EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 153EF-hand 3PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XSQLTKDEIE EVREVFDLFD FWDGRDGDVD AAKVGDLLRC LGMNPTEAQV
60 70 80 90 100
HQHGGTKKMG EKAYKLEEIL PIYEEMSSKD TGTAADEFME AFKTFDREGQ
110 120 130 140 150
GLISSAEIRN VLKMLGERIT EDQCNDIFTF CDIREDIDGN IKYEDLMKKV
160
MAGPFPDKSD
Length:160
Mass (Da):18,171
Last modified:July 5, 2004 - v2
Checksum:i37F32498B4EA3BE2
GO

Sequence databases

PIRiA25571.

Cross-referencesi

Sequence databases

PIRiA25571.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10C2-160[»]
3I5GX-ray2.60C2-160[»]
3I5HX-ray3.40C2-160[»]
3I5IX-ray3.30C2-160[»]
ProteinModelPortaliP05945.
SMRiP05945.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP05945.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLE_TODPA
AccessioniPrimary (citable) accession number: P05945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.