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Protein

Protein S100-A10

Gene

S100a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. regulation of cell differentiation Source: RGD
  2. regulation of cell growth Source: RGD
  3. response to antidepressant Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_300088. Orphan transporters.
REACT_324090. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
Nerve growth factor-induced protein 42C
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi628655. S100a10.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 9594Protein S100-A10PRO_0000144006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05943.
PRIDEiP05943.

PTM databases

PhosphoSiteiP05943.

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

ExpressionAtlasiP05943. baseline and differential.
GenevestigatoriP05943.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Scn10aQ629684EBI-1800351,EBI-1800320

Protein-protein interaction databases

IntActiP05943. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliP05943.
SMRiP05943. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiNOG26977.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05943.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP05943.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK
Length:95
Mass (Da):11,075
Last modified:January 22, 2007 - v2
Checksum:iEC12960C177F1BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA. Translation: AAA42097.1.
AF465254 Genomic DNA. Translation: AAO33353.1.
BC091565 mRNA. Translation: AAH91565.1.
PIRiA31373.
RefSeqiNP_112376.1. NM_031114.1.
UniGeneiRn.4083.

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneIDi81778.
KEGGirno:81778.
UCSCiRGD:628655. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA. Translation: AAA42097.1.
AF465254 Genomic DNA. Translation: AAO33353.1.
BC091565 mRNA. Translation: AAH91565.1.
PIRiA31373.
RefSeqiNP_112376.1. NM_031114.1.
UniGeneiRn.4083.

3D structure databases

ProteinModelPortaliP05943.
SMRiP05943. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05943. 6 interactions.

PTM databases

PhosphoSiteiP05943.

Proteomic databases

PaxDbiP05943.
PRIDEiP05943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneIDi81778.
KEGGirno:81778.
UCSCiRGD:628655. rat.

Organism-specific databases

CTDi6281.
RGDi628655. S100a10.

Phylogenomic databases

eggNOGiNOG26977.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05943.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP05943.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiREACT_300088. Orphan transporters.
REACT_324090. Dissolution of Fibrin Clot.

Miscellaneous databases

NextBioi615613.

Gene expression databases

ExpressionAtlasiP05943. baseline and differential.
GenevestigatoriP05943.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
    Masiakowski P., Shooter E.M.
    Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Park J.-Y., Kim W.-J., Chun S.-Y.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Lubec G., Afjehi-Sadat L.
    Submitted (OCT-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-54, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  5. "Annexin II light chain regulates sensory neuron-specific sodium channel expression."
    Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N.
    Nature 417:653-656(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCN10A.

Entry informationi

Entry nameiS10AA_RAT
AccessioniPrimary (citable) accession number: P05943
Secondary accession number(s): Q5BJ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.