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P05943 (S10AA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
Nerve growth factor-induced protein 42C
S100 calcium-binding protein A10
p10 protein
p11
Gene names
Name:S100a10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase By similarity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A. Ref.5

Induction

By nerve growth factor.

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Sequence similarities

Belongs to the S-100 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Scn10aQ629684EBI-1800351,EBI-1800320

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9594Protein S100-A10
PRO_0000144006

Regions

Region60 – 7112Ancestral calcium site

Amino acid modifications

Modified residue231N6-acetyllysine By similarity
Modified residue281N6-acetyllysine By similarity
Modified residue541N6-acetyllysine By similarity
Modified residue571N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P05943 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EC12960C177F1BBC

FASTA9511,075
        10         20         30         40         50         60 
MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL AVDKIMKDLD 

        70         80         90 
QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK 

« Hide

References

« Hide 'large scale' references
[1]"Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
Masiakowski P., Shooter E.M.
Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Park J.-Y., Kim W.-J., Chun S.-Y.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 38-54, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
[5]"Annexin II light chain regulates sensory neuron-specific sodium channel expression."
Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N.
Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCN10A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03627 mRNA. Translation: AAA42097.1.
AF465254 Genomic DNA. Translation: AAO33353.1.
BC091565 mRNA. Translation: AAH91565.1.
PIRA31373.
RefSeqNP_112376.1. NM_031114.1.
UniGeneRn.4083.

3D structure databases

ProteinModelPortalP05943.
SMRP05943. Positions 2-93.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP05943. 6 interactions.

PTM databases

PhosphoSiteP05943.

Proteomic databases

PaxDbP05943.
PRIDEP05943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneID81778.
KEGGrno:81778.
UCSCRGD:628655. rat.

Organism-specific databases

CTD6281.
RGD628655. S100a10.

Phylogenomic databases

eggNOGNOG26977.
GeneTreeENSGT00740000114954.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP05943.
KOK17274.
OMAAMETLMF.
OrthoDBEOG7R833W.
PhylomeDBP05943.
TreeFamTF332727.

Gene expression databases

GenevestigatorP05943.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF8. PTHR11639:SF8. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615613.

Entry information

Entry nameS10AA_RAT
AccessionPrimary (citable) accession number: P05943
Secondary accession number(s): Q5BJ98
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families