P05943 (S10AA_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A10

Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
Nerve growth factor-induced protein 42C
S100 calcium-binding protein A10
p10 protein
p11

Gene names

Name:

S100a10

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase By similarity.
Subunit structure	Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A. Ref.5
Induction	By nerve growth factor.
Miscellaneous	Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
Sequence similarities	Belongs to the S-100 family.

Ontologies

Keywords
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell differentiation Non-traceable author statement Ref.1. Source: RGD regulation of cell growth Non-traceable author statement Ref.1. Source: RGD
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 16420525. Source: RGD
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Scn10a	Q62968	4	EBI-1800351,EBI-1800320

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 95	94	Protein S100-A10		PRO_0000144006
Regions
	Region	60 – 71	12	Ancestral calcium site
Amino acid modifications
	Modified residue	23	1	N6-acetyllysine By similarity
	Modified residue	28	1	N6-acetyllysine By similarity
	Modified residue	54	1	N6-acetyllysine By similarity
	Modified residue	57	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P05943 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EC12960C177F1BBC	FASTA	95	11,075
	10 20 30 40 50 60 MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL AVDKIMKDLD 70 80 90 QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells." Masiakowski P., Shooter E.M. Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Park J.-Y., Kim W.-J., Chun S.-Y. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 38-54, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
[5]	"Annexin II light chain regulates sensory neuron-specific sodium channel expression." Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N. Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SCN10A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03627 mRNA. Translation: AAA42097.1. AF465254 Genomic DNA. Translation: AAO33353.1. BC091565 mRNA. Translation: AAH91565.1.
IPI	IPI00230921.
PIR	A31373.
RefSeq	NP_112376.1. NM_031114.1.
UniGene	Rn.4083.
3D structure databases
ProteinModelPortal	P05943.
SMR	P05943. Positions 2-93.
ModBase	Search...
Protein-protein interaction databases
IntAct	P05943. 1 interaction.
PTM databases
PhosphoSite	P05943.
Proteomic databases
PaxDb	P05943.
PRIDE	P05943.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneID	81778.
KEGG	rno:81778.
UCSC	RGD:628655. rat.
Organism-specific databases
CTD	6281.
RGD	628655. S100a10.
Phylogenomic databases
eggNOG	NOG26977.
GeneTree	ENSGT00690000101829.
HOGENOM	HOG000246968.
HOVERGEN	HBG001479.
InParanoid	P05943.
OMA	AMETLMF.
OrthoDB	EOG4DNF5Z.
Gene expression databases
ArrayExpress	P05943.
Genevestigator	P05943.
GermOnline	ENSRNOG00000023226. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Pfam	PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615613.

Entry information

Entry name

S10AA_RAT

Accession

Primary (citable) accession number: P05943
Secondary accession number(s): Q5BJ98

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program