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P05943

- S10AA_RAT

UniProt

P05943 - S10AA_RAT

Protein

Protein S100-A10

Gene

S100a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of cell differentiation Source: RGD
    2. regulation of cell growth Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A10
    Alternative name(s):
    Calpactin I light chain
    Calpactin-1 light chain
    Cellular ligand of annexin II
    Nerve growth factor-induced protein 42C
    S100 calcium-binding protein A10
    p10 protein
    p11
    Gene namesi
    Name:S100a10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi628655. S100a10.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 9594Protein S100-A10PRO_0000144006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysineBy similarity
    Modified residuei28 – 281N6-acetyllysineBy similarity
    Modified residuei54 – 541N6-acetyllysineBy similarity
    Modified residuei57 – 571N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP05943.
    PRIDEiP05943.

    PTM databases

    PhosphoSiteiP05943.

    Expressioni

    Inductioni

    By nerve growth factor.

    Gene expression databases

    GenevestigatoriP05943.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Scn10aQ629684EBI-1800351,EBI-1800320

    Protein-protein interaction databases

    IntActiP05943. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP05943.
    SMRiP05943. Positions 2-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 7112Ancestral calcium siteAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated

    Phylogenomic databases

    eggNOGiNOG26977.
    GeneTreeiENSGT00740000114954.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP05943.
    KOiK17274.
    OMAiAMETLMF.
    OrthoDBiEOG7R833W.
    PhylomeDBiP05943.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL   50
    AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK 95
    Length:95
    Mass (Da):11,075
    Last modified:January 23, 2007 - v2
    Checksum:iEC12960C177F1BBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03627 mRNA. Translation: AAA42097.1.
    AF465254 Genomic DNA. Translation: AAO33353.1.
    BC091565 mRNA. Translation: AAH91565.1.
    PIRiA31373.
    RefSeqiNP_112376.1. NM_031114.1.
    UniGeneiRn.4083.

    Genome annotation databases

    EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
    GeneIDi81778.
    KEGGirno:81778.
    UCSCiRGD:628655. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03627 mRNA. Translation: AAA42097.1 .
    AF465254 Genomic DNA. Translation: AAO33353.1 .
    BC091565 mRNA. Translation: AAH91565.1 .
    PIRi A31373.
    RefSeqi NP_112376.1. NM_031114.1.
    UniGenei Rn.4083.

    3D structure databases

    ProteinModelPortali P05943.
    SMRi P05943. Positions 2-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P05943. 6 interactions.

    PTM databases

    PhosphoSitei P05943.

    Proteomic databases

    PaxDbi P05943.
    PRIDEi P05943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000035240 ; ENSRNOP00000037097 ; ENSRNOG00000023226 .
    GeneIDi 81778.
    KEGGi rno:81778.
    UCSCi RGD:628655. rat.

    Organism-specific databases

    CTDi 6281.
    RGDi 628655. S100a10.

    Phylogenomic databases

    eggNOGi NOG26977.
    GeneTreei ENSGT00740000114954.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P05943.
    KOi K17274.
    OMAi AMETLMF.
    OrthoDBi EOG7R833W.
    PhylomeDBi P05943.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 615613.

    Gene expression databases

    Genevestigatori P05943.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF56. PTHR11639:SF56. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
      Masiakowski P., Shooter E.M.
      Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Park J.-Y., Kim W.-J., Chun S.-Y.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 38-54, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.
    5. "Annexin II light chain regulates sensory neuron-specific sodium channel expression."
      Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N.
      Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCN10A.

    Entry informationi

    Entry nameiS10AA_RAT
    AccessioniPrimary (citable) accession number: P05943
    Secondary accession number(s): Q5BJ98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3