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Protein

Protein S100-A10

Gene

S100a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of cell differentiation Source: RGD
  • regulation of cell growth Source: RGD
  • response to antidepressant Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
Nerve growth factor-induced protein 42C
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi628655. S100a10.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 9594Protein S100-A10PRO_0000144006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05943.
PRIDEiP05943.

PTM databases

PhosphoSiteiP05943.

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

ExpressionAtlasiP05943. baseline and differential.
GenevisibleiP05943. RN.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Scn10aQ629684EBI-1800351,EBI-1800320

Protein-protein interaction databases

IntActiP05943. 6 interactions.
STRINGi10116.ENSRNOP00000037097.

Structurei

3D structure databases

ProteinModelPortaliP05943.
SMRiP05943. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiNOG26977.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05943.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP05943.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK
Length:95
Mass (Da):11,075
Last modified:January 23, 2007 - v2
Checksum:iEC12960C177F1BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA. Translation: AAA42097.1.
AF465254 Genomic DNA. Translation: AAO33353.1.
BC091565 mRNA. Translation: AAH91565.1.
PIRiA31373.
RefSeqiNP_112376.1. NM_031114.1.
UniGeneiRn.4083.

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneIDi81778.
KEGGirno:81778.
UCSCiRGD:628655. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA. Translation: AAA42097.1.
AF465254 Genomic DNA. Translation: AAO33353.1.
BC091565 mRNA. Translation: AAH91565.1.
PIRiA31373.
RefSeqiNP_112376.1. NM_031114.1.
UniGeneiRn.4083.

3D structure databases

ProteinModelPortaliP05943.
SMRiP05943. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05943. 6 interactions.
STRINGi10116.ENSRNOP00000037097.

PTM databases

PhosphoSiteiP05943.

Proteomic databases

PaxDbiP05943.
PRIDEiP05943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226.
GeneIDi81778.
KEGGirno:81778.
UCSCiRGD:628655. rat.

Organism-specific databases

CTDi6281.
RGDi628655. S100a10.

Phylogenomic databases

eggNOGiNOG26977.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05943.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP05943.
TreeFamiTF332727.

Miscellaneous databases

NextBioi615613.
PROiP05943.

Gene expression databases

ExpressionAtlasiP05943. baseline and differential.
GenevisibleiP05943. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
    Masiakowski P., Shooter E.M.
    Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Park J.-Y., Kim W.-J., Chun S.-Y.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-54, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  5. "Annexin II light chain regulates sensory neuron-specific sodium channel expression."
    Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N.
    Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCN10A.

Entry informationi

Entry nameiS10AA_RAT
AccessioniPrimary (citable) accession number: P05943
Secondary accession number(s): Q5BJ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.