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P05942

- S10A4_RAT

UniProt

P05942 - S10A4_RAT

Protein

Protein S100-A4

Gene

S100a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin binding Source: RGD
    2. calcium-dependent protein binding Source: RGD
    3. calcium ion binding Source: RGD
    4. protein binding Source: RGD
    5. protein heterodimerization activity Source: RGD
    6. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A4
    Alternative name(s):
    Metastasin
    Nerve growth factor-induced protein 42A
    P9K
    Placental calcium-binding protein
    S100 calcium-binding protein A4
    Gene namesi
    Name:S100a4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi3245. S100a4.

    Subcellular locationi

    GO - Cellular componenti

    1. neuron projection Source: RGD
    2. nucleus Source: Ensembl
    3. perinuclear region of cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 101100Protein S100-A4PRO_0000143979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei35 – 351N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP05942.
    PRIDEiP05942.

    Expressioni

    Inductioni

    By nerve growth factor.

    Gene expression databases

    GenevestigatoriP05942.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015958.

    Structurei

    3D structure databases

    ProteinModelPortaliP05942.
    SMRiP05942. Positions 1-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG40931.
    GeneTreeiENSGT00740000114986.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP05942.
    OMAiTATHAYD.
    OrthoDBiEOG7R833W.
    PhylomeDBiP05942.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028496. S100-A4.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF15. PTHR11639:SF15. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05942-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT    50
    DEAAFQKLMN NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK 100
    K 101
    Length:101
    Mass (Da):11,776
    Last modified:November 1, 1988 - v1
    Checksum:iEA0619CEE4F487C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06916 Genomic DNA. Translation: CAA30014.1.
    J03628 mRNA. Translation: AAA42098.1.
    X64022 mRNA. No translation available.
    X64023 mRNA. No translation available.
    PIRiS01759.
    RefSeqiNP_036750.1. NM_012618.2.
    XP_006232654.1. XM_006232592.1.
    UniGeneiRn.504.

    Genome annotation databases

    EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
    GeneIDi24615.
    KEGGirno:24615.
    UCSCiRGD:3245. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06916 Genomic DNA. Translation: CAA30014.1 .
    J03628 mRNA. Translation: AAA42098.1 .
    X64022 mRNA. No translation available.
    X64023 mRNA. No translation available.
    PIRi S01759.
    RefSeqi NP_036750.1. NM_012618.2.
    XP_006232654.1. XM_006232592.1.
    UniGenei Rn.504.

    3D structure databases

    ProteinModelPortali P05942.
    SMRi P05942. Positions 1-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015958.

    Proteomic databases

    PaxDbi P05942.
    PRIDEi P05942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015958 ; ENSRNOP00000015958 ; ENSRNOG00000011821 .
    GeneIDi 24615.
    KEGGi rno:24615.
    UCSCi RGD:3245. rat.

    Organism-specific databases

    CTDi 6275.
    RGDi 3245. S100a4.

    Phylogenomic databases

    eggNOGi NOG40931.
    GeneTreei ENSGT00740000114986.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P05942.
    OMAi TATHAYD.
    OrthoDBi EOG7R833W.
    PhylomeDBi P05942.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 603862.
    PROi P05942.

    Gene expression databases

    Genevestigatori P05942.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028496. S100-A4.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF15. PTHR11639:SF15. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
      Masiakowski P., Shooter E.M.
      Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and sequence of the gene for p9Ka. A cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein."
      Barraclough R., Savin J., Dube S.K., Rudland P.S.
      J. Mol. Biol. 198:13-20(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein."
      de Vouge M.W., Mukherjee B.B.
      Oncogene 7:109-119(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 3-101.

    Entry informationi

    Entry nameiS10A4_RAT
    AccessioniPrimary (citable) accession number: P05942
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3