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P05942 (S10A4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Nerve growth factor-induced protein 42A
P9K
Placental calcium-binding protein
S100 calcium-binding protein A4
Gene names
Name:S100a4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode By similarity.

Induction

By nerve growth factor.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 101100Protein S100-A4
PRO_0000143979

Regions

Domain12 – 4736EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity Potential
Calcium binding63 – 74122; high affinity Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue351N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P05942 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: EA0619CEE4F487C1

FASTA10111,776
        10         20         30         40         50         60 
MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT DEAAFQKLMN 

        70         80         90        100 
NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK K 

« Hide

References

[1]"Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
Masiakowski P., Shooter E.M.
Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and sequence of the gene for p9Ka. A cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein."
Barraclough R., Savin J., Dube S.K., Rudland P.S.
J. Mol. Biol. 198:13-20(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein."
de Vouge M.W., Mukherjee B.B.
Oncogene 7:109-119(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 3-101.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRS01759.
RefSeqNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.1.
UniGeneRn.504.

3D structure databases

ProteinModelPortalP05942.
SMRP05942. Positions 1-101.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000015958.

Proteomic databases

PaxDbP05942.
PRIDEP05942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneID24615.
KEGGrno:24615.
UCSCRGD:3245. rat.

Organism-specific databases

CTD6275.
RGD3245. S100a4.

Phylogenomic databases

eggNOGNOG40931.
GeneTreeENSGT00740000114986.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP05942.
OMANEFFEGC.
OrthoDBEOG7R833W.
PhylomeDBP05942.
TreeFamTF332727.

Gene expression databases

GenevestigatorP05942.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028496. S100-A2/S100-A4.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF15. PTHR11639:SF15. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603862.
PROP05942.

Entry information

Entry nameS10A4_RAT
AccessionPrimary (citable) accession number: P05942
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families