Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05942

- S10A4_RAT

UniProt

P05942 - S10A4_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein S100-A4

Gene

S100a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. actin binding Source: RGD
  2. calcium-dependent protein binding Source: RGD
  3. calcium ion binding Source: RGD
  4. poly(A) RNA binding Source: Ensembl
  5. protein heterodimerization activity Source: RGD
  6. protein homodimerization activity Source: RGD

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Nerve growth factor-induced protein 42A
P9K
Placental calcium-binding protein
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi3245. S100a4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. neuron projection Source: RGD
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A4PRO_0000143979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei35 – 351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05942.
PRIDEiP05942.

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

GenevestigatoriP05942.

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958.

Structurei

3D structure databases

ProteinModelPortaliP05942.
SMRiP05942. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40931.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05942.
OMAiTATHAYD.
OrthoDBiEOG7R833W.
PhylomeDBiP05942.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028496. S100-A4.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF15. PTHR11639:SF15. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05942-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT
60 70 80 90 100
DEAAFQKLMN NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,776
Last modified:November 1, 1988 - v1
Checksum:iEA0619CEE4F487C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRiS01759.
RefSeqiNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.2.
UniGeneiRn.504.

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneIDi24615.
KEGGirno:24615.
UCSCiRGD:3245. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1 .
J03628 mRNA. Translation: AAA42098.1 .
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRi S01759.
RefSeqi NP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.2.
UniGenei Rn.504.

3D structure databases

ProteinModelPortali P05942.
SMRi P05942. Positions 1-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015958.

Proteomic databases

PaxDbi P05942.
PRIDEi P05942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015958 ; ENSRNOP00000015958 ; ENSRNOG00000011821 .
GeneIDi 24615.
KEGGi rno:24615.
UCSCi RGD:3245. rat.

Organism-specific databases

CTDi 6275.
RGDi 3245. S100a4.

Phylogenomic databases

eggNOGi NOG40931.
GeneTreei ENSGT00760000119034.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P05942.
OMAi TATHAYD.
OrthoDBi EOG7R833W.
PhylomeDBi P05942.
TreeFami TF332727.

Miscellaneous databases

NextBioi 603862.
PROi P05942.

Gene expression databases

Genevestigatori P05942.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028496. S100-A4.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view ]
PANTHERi PTHR11639:SF15. PTHR11639:SF15. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
    Masiakowski P., Shooter E.M.
    Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence of the gene for p9Ka. A cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein."
    Barraclough R., Savin J., Dube S.K., Rudland P.S.
    J. Mol. Biol. 198:13-20(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein."
    de Vouge M.W., Mukherjee B.B.
    Oncogene 7:109-119(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 3-101.

Entry informationi

Entry nameiS10A4_RAT
AccessioniPrimary (citable) accession number: P05942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3