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Protein

Protein S100-A4

Gene

S100a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. actin binding Source: RGD
  2. calcium-dependent protein binding Source: RGD
  3. calcium ion binding Source: RGD
  4. poly(A) RNA binding Source: Ensembl
  5. protein heterodimerization activity Source: RGD
  6. protein homodimerization activity Source: RGD

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Nerve growth factor-induced protein 42A
P9K
Placental calcium-binding protein
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3245. S100a4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. neuron projection Source: RGD
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A4PRO_0000143979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei35 – 351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05942.
PRIDEiP05942.

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

GenevestigatoriP05942.

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958.

Structurei

3D structure databases

ProteinModelPortaliP05942.
SMRiP05942. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40931.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05942.
OMAiNEFFEGC.
OrthoDBiEOG7R833W.
PhylomeDBiP05942.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028496. S100-A4.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF15. PTHR11639:SF15. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT
60 70 80 90 100
DEAAFQKLMN NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,776
Last modified:October 31, 1988 - v1
Checksum:iEA0619CEE4F487C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRiS01759.
RefSeqiNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.2.
UniGeneiRn.504.

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneIDi24615.
KEGGirno:24615.
UCSCiRGD:3245. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRiS01759.
RefSeqiNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.2.
UniGeneiRn.504.

3D structure databases

ProteinModelPortaliP05942.
SMRiP05942. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958.

Proteomic databases

PaxDbiP05942.
PRIDEiP05942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneIDi24615.
KEGGirno:24615.
UCSCiRGD:3245. rat.

Organism-specific databases

CTDi6275.
RGDi3245. S100a4.

Phylogenomic databases

eggNOGiNOG40931.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05942.
OMAiNEFFEGC.
OrthoDBiEOG7R833W.
PhylomeDBiP05942.
TreeFamiTF332727.

Miscellaneous databases

NextBioi603862.
PROiP05942.

Gene expression databases

GenevestigatoriP05942.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028496. S100-A4.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF15. PTHR11639:SF15. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells."
    Masiakowski P., Shooter E.M.
    Proc. Natl. Acad. Sci. U.S.A. 85:1277-1281(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence of the gene for p9Ka. A cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein."
    Barraclough R., Savin J., Dube S.K., Rudland P.S.
    J. Mol. Biol. 198:13-20(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein."
    de Vouge M.W., Mukherjee B.B.
    Oncogene 7:109-119(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 3-101.

Entry informationi

Entry nameiS10A4_RAT
AccessioniPrimary (citable) accession number: P05942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: October 31, 1988
Last modified: March 3, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.