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Protein

Protein S100-A4

Gene

S100a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: RGD
  • calcium-dependent protein binding Source: RGD
  • calcium ion binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • RAGE receptor binding Source: Ensembl
  • RNA binding Source: Ensembl
  • transition metal ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Nerve growth factor-induced protein 42A
P9K
Placental calcium-binding protein
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3245. S100a4.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439792 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05942.
PRIDEiP05942.

PTM databases

iPTMnetiP05942.
PhosphoSitePlusiP05942.

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

BgeeiENSRNOG00000011821.
GenevisibleiP05942. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: RGD
  • calcium-dependent protein binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • RAGE receptor binding Source: Ensembl

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958.

Structurei

3D structure databases

ProteinModelPortaliP05942.
SMRiP05942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05942.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
PhylomeDBiP05942.
TreeFamiTF332727.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT
60 70 80 90 100
DEAAFQKLMN NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,776
Last modified:November 1, 1988 - v1
Checksum:iEA0619CEE4F487C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRiS01759.
RefSeqiNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.3.
UniGeneiRn.504.

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneIDi24615.
KEGGirno:24615.
UCSCiRGD:3245. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA. Translation: CAA30014.1.
J03628 mRNA. Translation: AAA42098.1.
X64022 mRNA. No translation available.
X64023 mRNA. No translation available.
PIRiS01759.
RefSeqiNP_036750.1. NM_012618.2.
XP_006232654.1. XM_006232592.3.
UniGeneiRn.504.

3D structure databases

ProteinModelPortaliP05942.
SMRiP05942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958.

PTM databases

iPTMnetiP05942.
PhosphoSitePlusiP05942.

Proteomic databases

PaxDbiP05942.
PRIDEiP05942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821.
GeneIDi24615.
KEGGirno:24615.
UCSCiRGD:3245. rat.

Organism-specific databases

CTDi6275.
RGDi3245. S100a4.

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP05942.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
PhylomeDBiP05942.
TreeFamiTF332727.

Miscellaneous databases

PROiPR:P05942.

Gene expression databases

BgeeiENSRNOG00000011821.
GenevisibleiP05942. RN.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10A4_RAT
AccessioniPrimary (citable) accession number: P05942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 10, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.