P05941 (PRVB_OPSTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Parvalbumin beta Alternative name(s): Parvalbumin IIIF
Organism	Opsanus tau (Oyster toadfish) (Gadus tau)
Taxonomic identifier	8068 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Paracanthopterygii › Batrachoidiformes › Batrachoididae › Batrachoidinae › Opsanus

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Miscellaneous	Three parvalbumin isotypes, in nearly equal proportion, are found in toadfish white trunk muscle whereas only one main component (IIIF) is present in the swimbladder muscle of adult specimens.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	Parvalbumin beta		PRO_0000073616
Regions
	Domain	38 – 73	36	EF-hand 1
	Domain	77 – 109	33	EF-hand 2
	Calcium binding	51 – 62	12	1
	Calcium binding	90 – 101	12	2
Amino acid modifications
	Modified residue	1	1	N-acetylserine

Sequences

	Sequence		Length	Mass (Da)
	P05941 [UniParc]. Last modified May 1, 1992. Version 2. Checksum: 2C90F7738AD4E542	FASTA	109	11,757
	10 20 30 40 50 60 SFAGILSDAD IDAALAACQA AESFKHKEFF AKVGLSAKTP DVIKKAFYVI DQDKSGFIEE 70 80 90 100 DELKLFLQNF ASSARALTDK ETETFLKAGD SDGDGKIGID EFADLVKEA

References

[1]	"The amino acid sequence of the parvalbumin from the very fast swimbladder muscle of the toadfish (Opsanus tau)." Gerday C., Collins S., Gerardin-Otthiers N. Comp. Biochem. Physiol. 93B:49-55(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Fast swimbladder muscle.
[2]	"Crystal structure study of Opsanus tau parvalbumin by multiwavelength anomalous diffraction." Kahn R., Fourme R., Bosshard R., Chiadmi M., Risler J.-L., Dideberg O., Wery J.P. FEBS Lett. 179:133-137(1985) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[3]	"Crystallization and structure at 3.2-A resolution of a terbium parvalbumin." Wery J.P., Dideberg O., Charlier P., Gerday C. FEBS Lett. 182:103-106(1985) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).

Cross-references

Sequence databases
PIR	PVTFB3. JL0094.
3D structure databases
ProteinModelPortal	P05941.
SMR	P05941. Positions 1-107.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG107490.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR008080. Parvalbumin. [Graphical view]
PANTHER	PTHR11653. PTHR11653. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRVB_OPSTA

Accession

Primary (citable) accession number: P05941

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program