P05939 (PRVB_SQUCE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Parvalbumin beta Alternative name(s): Parvalbumin V
Organism	Squalius cephalus (Chub) (Leuciscus cephalus)
Taxonomic identifier	8284 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Squalius

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions By similarity.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Parvalbumin beta		PRO_0000073612
Regions
	Domain	36 – 71	36	EF-hand 1
	Domain	75 – 106	32	EF-hand 2
	Calcium binding	51 – 62	12	1
	Calcium binding	90 – 101	12	2
Amino acid modifications
	Modified residue	1	1	N-acetylalanine

Sequences

	Sequence		Length	Mass (Da)
	P05939 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: BF27C2A24AFCCB4D	FASTA	106	11,263
	10 20 30 40 50 60 AFGLKEADIT AALEACKAAD SFNHKAFFAK VGMSAKSAGD VKKAFEIIDE DKSGFIEEEE 70 80 90 100 LKLFLQNFKA GARALTDAET KIFLKAGDAD GDGKIGIDEF AALVKA

References

[1]	"Phylogenetic relationships between Cyprinidae Parvalbumins-II. The amino acid sequence of the Parvalbumin V of Chub (Leuciscus cephalus L.)." Gerday C., Collins S., Piront A. Comp. Biochem. Physiol. 61B:451-457(1978) Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ProteinModelPortal	P05939.
SMR	P05939. Positions 4-106.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG107490.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR008080. Parvalbumin. [Graphical view]
PANTHER	PTHR11653. PTHR11653. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRVB_SQUCE

Accession

Primary (citable) accession number: P05939

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program